Atypical Optic Neuritis

Eric D. Gaier, Katherine Boudreault, Joseph F. Rizzo, Julie Falardeau, Dean M. Cestari

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations


Classic demyelinative optic neuritis is associated with multiple sclerosis and typically carries a good prognosis for visual recovery. This disorder is well characterized with respect to its presentation and clinical features by baseline data obtained through the optic neuritis treatment trial and numerous other studies. Atypical optic neuritis entails clinical manifestations that deviate from this classic pattern of features. Clinical signs and symptoms that deviate from the typical presentation should prompt consideration of less common etiologies. Atypical features to consider include lack of pain, simultaneous or near-simultaneous onset, lack of response to or relapse upon tapering from corticosteroids, or optic nerve head or peripapillary hemorrhages. The most important alternative etiologies to consider and the steps towards their respective diagnostic evaluations are suggested for these atypical features.

Original languageEnglish (US)
Article number76
JournalCurrent neurology and neuroscience reports
Issue number12
StatePublished - Dec 1 2015


  • Chronic relapsing inflammatory optic neuropathy
  • Ischemic optic neuropathy
  • Lyme borreliosis
  • Neuromyelitis optica (NMO)
  • Optic neuritis
  • Sarcoidosis

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology


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