Atypical human T-cell lymphotropic virus type-I-associated T-cell lymphoma in a low-prevalence Alaska native population

Implications for disease surveillance

M. Davidson, Rita Braziel, M. D. Lairmore, S. Jacobson, J. M. Sprott, S. B. Tucker, P. H. Levine, J. E. Kaplan

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

An atypical case of adult T-cell leukemia/lymphoma (ATL) associated with human T-cell lymphotropic virus type I (HTLV-I) occurred in a 46-year-old Inupiat Eskimo man with no behavioral risk factors for HTLV-I infection. The case was characterized by lack of atypical circulating lymphocytes, hypercalcemia, and opportunistic infections; and by complete remission of the initial renal parenchymal lymphoma. The lymphoma cells had a helper T-cell (CD4) immunophenotype. Serum antibodies to HTLV I/II, detected by Western immunoblot, were identified in specimens collected 31 months before the onset of illness, at the time of diagnosis, and up to 37 months later, shortly before the patient's death. Polymerase chain reaction was used to identify HTLV-I DNA in peripheral blood mononuclear cells and in lymphoma in involved skin. Clinicians should be alert to sporadic cases of both atypical and classic ATL, even in populations in which the prevalence of HTLV-I infection is low.

Original languageEnglish (US)
Pages (from-to)4072-4076
Number of pages5
JournalCancer
Volume71
Issue number12
StatePublished - 1993

Fingerprint

T-Cell Lymphoma
Viruses
T-Lymphocytes
Adult T Cell Leukemia Lymphoma
Lymphoma
Virus Diseases
Population
Human T-lymphotropic virus 2
Inuits
DNA Viruses
Opportunistic Infections
Hypercalcemia
Helper-Inducer T-Lymphocytes
Blood Cells
Western Blotting
Lymphocytes
Kidney
Polymerase Chain Reaction
Skin
Alaska Natives

Keywords

  • adult T-cell lymphoma/leukemia
  • Alaska Native
  • Eskimo
  • human T-cell lymphotropic virus type I (HTLV-I)
  • lymphoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Davidson, M., Braziel, R., Lairmore, M. D., Jacobson, S., Sprott, J. M., Tucker, S. B., ... Kaplan, J. E. (1993). Atypical human T-cell lymphotropic virus type-I-associated T-cell lymphoma in a low-prevalence Alaska native population: Implications for disease surveillance. Cancer, 71(12), 4072-4076.

Atypical human T-cell lymphotropic virus type-I-associated T-cell lymphoma in a low-prevalence Alaska native population : Implications for disease surveillance. / Davidson, M.; Braziel, Rita; Lairmore, M. D.; Jacobson, S.; Sprott, J. M.; Tucker, S. B.; Levine, P. H.; Kaplan, J. E.

In: Cancer, Vol. 71, No. 12, 1993, p. 4072-4076.

Research output: Contribution to journalArticle

Davidson, M, Braziel, R, Lairmore, MD, Jacobson, S, Sprott, JM, Tucker, SB, Levine, PH & Kaplan, JE 1993, 'Atypical human T-cell lymphotropic virus type-I-associated T-cell lymphoma in a low-prevalence Alaska native population: Implications for disease surveillance', Cancer, vol. 71, no. 12, pp. 4072-4076.
Davidson, M. ; Braziel, Rita ; Lairmore, M. D. ; Jacobson, S. ; Sprott, J. M. ; Tucker, S. B. ; Levine, P. H. ; Kaplan, J. E. / Atypical human T-cell lymphotropic virus type-I-associated T-cell lymphoma in a low-prevalence Alaska native population : Implications for disease surveillance. In: Cancer. 1993 ; Vol. 71, No. 12. pp. 4072-4076.
@article{8f0180c5129a47d3b3ce1b9cca057d5a,
title = "Atypical human T-cell lymphotropic virus type-I-associated T-cell lymphoma in a low-prevalence Alaska native population: Implications for disease surveillance",
abstract = "An atypical case of adult T-cell leukemia/lymphoma (ATL) associated with human T-cell lymphotropic virus type I (HTLV-I) occurred in a 46-year-old Inupiat Eskimo man with no behavioral risk factors for HTLV-I infection. The case was characterized by lack of atypical circulating lymphocytes, hypercalcemia, and opportunistic infections; and by complete remission of the initial renal parenchymal lymphoma. The lymphoma cells had a helper T-cell (CD4) immunophenotype. Serum antibodies to HTLV I/II, detected by Western immunoblot, were identified in specimens collected 31 months before the onset of illness, at the time of diagnosis, and up to 37 months later, shortly before the patient's death. Polymerase chain reaction was used to identify HTLV-I DNA in peripheral blood mononuclear cells and in lymphoma in involved skin. Clinicians should be alert to sporadic cases of both atypical and classic ATL, even in populations in which the prevalence of HTLV-I infection is low.",
keywords = "adult T-cell lymphoma/leukemia, Alaska Native, Eskimo, human T-cell lymphotropic virus type I (HTLV-I), lymphoma",
author = "M. Davidson and Rita Braziel and Lairmore, {M. D.} and S. Jacobson and Sprott, {J. M.} and Tucker, {S. B.} and Levine, {P. H.} and Kaplan, {J. E.}",
year = "1993",
language = "English (US)",
volume = "71",
pages = "4072--4076",
journal = "Cancer",
issn = "0008-543X",
publisher = "John Wiley and Sons Inc.",
number = "12",

}

TY - JOUR

T1 - Atypical human T-cell lymphotropic virus type-I-associated T-cell lymphoma in a low-prevalence Alaska native population

T2 - Implications for disease surveillance

AU - Davidson, M.

AU - Braziel, Rita

AU - Lairmore, M. D.

AU - Jacobson, S.

AU - Sprott, J. M.

AU - Tucker, S. B.

AU - Levine, P. H.

AU - Kaplan, J. E.

PY - 1993

Y1 - 1993

N2 - An atypical case of adult T-cell leukemia/lymphoma (ATL) associated with human T-cell lymphotropic virus type I (HTLV-I) occurred in a 46-year-old Inupiat Eskimo man with no behavioral risk factors for HTLV-I infection. The case was characterized by lack of atypical circulating lymphocytes, hypercalcemia, and opportunistic infections; and by complete remission of the initial renal parenchymal lymphoma. The lymphoma cells had a helper T-cell (CD4) immunophenotype. Serum antibodies to HTLV I/II, detected by Western immunoblot, were identified in specimens collected 31 months before the onset of illness, at the time of diagnosis, and up to 37 months later, shortly before the patient's death. Polymerase chain reaction was used to identify HTLV-I DNA in peripheral blood mononuclear cells and in lymphoma in involved skin. Clinicians should be alert to sporadic cases of both atypical and classic ATL, even in populations in which the prevalence of HTLV-I infection is low.

AB - An atypical case of adult T-cell leukemia/lymphoma (ATL) associated with human T-cell lymphotropic virus type I (HTLV-I) occurred in a 46-year-old Inupiat Eskimo man with no behavioral risk factors for HTLV-I infection. The case was characterized by lack of atypical circulating lymphocytes, hypercalcemia, and opportunistic infections; and by complete remission of the initial renal parenchymal lymphoma. The lymphoma cells had a helper T-cell (CD4) immunophenotype. Serum antibodies to HTLV I/II, detected by Western immunoblot, were identified in specimens collected 31 months before the onset of illness, at the time of diagnosis, and up to 37 months later, shortly before the patient's death. Polymerase chain reaction was used to identify HTLV-I DNA in peripheral blood mononuclear cells and in lymphoma in involved skin. Clinicians should be alert to sporadic cases of both atypical and classic ATL, even in populations in which the prevalence of HTLV-I infection is low.

KW - adult T-cell lymphoma/leukemia

KW - Alaska Native

KW - Eskimo

KW - human T-cell lymphotropic virus type I (HTLV-I)

KW - lymphoma

UR - http://www.scopus.com/inward/record.url?scp=0027194143&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027194143&partnerID=8YFLogxK

M3 - Article

VL - 71

SP - 4072

EP - 4076

JO - Cancer

JF - Cancer

SN - 0008-543X

IS - 12

ER -