Atypical central nervous system lymphoma at the cranial base: Report of four cases

Simon M. Roman-Goldstein, Anthony Jones, John B. Delashaw, Sean McMenomey, Edward Neuwelt

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

OBJECTIVE AND IMPORTANCE: Primary central nervous system lymphoma is a disease with increasing incidence. Atypical presentations are becoming more frequent. CLINICAL PRESENTATION: Three patients bearing cavernous sinus lesions presented initially with periorbital pain and diplopia. Tolosa-Hunt syndrome was the initial presumptive diagnosis for two patients, and meningioma was the diagnosis for the third patient. A fourth patient presented with left ear pain, and a mass in the left internal auditory canal was thought to represent an acoustic neuroma. INTERVENTION: For all four patients, an operative pathological diagnosis was obtained and was compatible with central nervous system lymphoma. All patients were treated with osmotic blood-brain barrier disruption with intra-arterial chemotherapy using a methotrexate-based regimen. CONCLUSION: All four cases included atypical presentations of lymphoma. These cases again illustrate that a correct diagnosis cannot be obtained based only on imaging and clinical findings.

Original languageEnglish (US)
Pages (from-to)613-615
Number of pages3
JournalNeurosurgery
Volume43
Issue number3
StatePublished - Sep 1998

Fingerprint

Skull Base
Lymphoma
Central Nervous System
Tolosa-Hunt Syndrome
Pain
Cavernous Sinus
Diplopia
Acoustic Neuroma
Meningioma
Blood-Brain Barrier
Methotrexate
Ear
Drug Therapy
Incidence

Keywords

  • CNS lymphoma
  • Extra-axial

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Roman-Goldstein, S. M., Jones, A., Delashaw, J. B., McMenomey, S., & Neuwelt, E. (1998). Atypical central nervous system lymphoma at the cranial base: Report of four cases. Neurosurgery, 43(3), 613-615.

Atypical central nervous system lymphoma at the cranial base : Report of four cases. / Roman-Goldstein, Simon M.; Jones, Anthony; Delashaw, John B.; McMenomey, Sean; Neuwelt, Edward.

In: Neurosurgery, Vol. 43, No. 3, 09.1998, p. 613-615.

Research output: Contribution to journalArticle

Roman-Goldstein, SM, Jones, A, Delashaw, JB, McMenomey, S & Neuwelt, E 1998, 'Atypical central nervous system lymphoma at the cranial base: Report of four cases', Neurosurgery, vol. 43, no. 3, pp. 613-615.
Roman-Goldstein SM, Jones A, Delashaw JB, McMenomey S, Neuwelt E. Atypical central nervous system lymphoma at the cranial base: Report of four cases. Neurosurgery. 1998 Sep;43(3):613-615.
Roman-Goldstein, Simon M. ; Jones, Anthony ; Delashaw, John B. ; McMenomey, Sean ; Neuwelt, Edward. / Atypical central nervous system lymphoma at the cranial base : Report of four cases. In: Neurosurgery. 1998 ; Vol. 43, No. 3. pp. 613-615.
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