ATX-LPA receptor axis in inflammation and cancer

Shuying Liu, Mandi Murph, Nattapon Panupinthu, Gordon B. Mills

    Research output: Contribution to journalReview article

    68 Scopus citations

    Abstract

    Lysophosphatidic acid (LPA, 1- or 2-acyl-sn-glycerol 3-phosphate) mediates a plethora of physiological and pathological activities via interactions with a series of high affinity G proteincoupled receptors (GPCR). Both LPA receptor family members and autotaxin (ATX/LysoPLD), the primary LPA-producing enzyme, are aberrantly expressed in many human breast cancers and several other cancer lineages. Using transgenic mice expressing either an LPA receptor or ATX, we recently demonstrated that the ATX-LPA receptor axis plays a causal role in breast tumorigenesis and cancer-related inflammation, further validating the ATX-LPA receptor axis as a rich therapeutic target in cancer.

    Original languageEnglish (US)
    Pages (from-to)3695-3701
    Number of pages7
    JournalCell Cycle
    Volume8
    Issue number22
    DOIs
    StatePublished - Nov 15 2009

    Keywords

    • ATX
    • Breast cancer
    • Cytokines
    • G protein-coupled receptor
    • Inflammation
    • LPA
    • Target therapy

    ASJC Scopus subject areas

    • Molecular Biology
    • Developmental Biology
    • Cell Biology

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