Attenuation of ethanol-induced conditioned taste aversion in mice sensitized to the locomotor stimulant effects of ethanol

Christina N. Lessov, Fred O. Risinger, Tamara J. Phillips

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

This study examined the effect of repeated ethanol (EtOH) injections that induced behavioral sensitization on subsequent acquisition of EtOH- and lithium chloride (LiCl)-induced conditioned taste aversion (CTA). CTA acquisition was assessed in independent groups of EtOH-sensitized and nonsensitized genetically heterogeneous female mice after injections of saline; 1, 2, or 4 g/kg EtOH: or 2 or 4 mEq/kg LiCl. Saline and 1 g/kg EtOH did not induce CTA. Four g/kg EtOH and 4 mEq/kg LiCl induced similar levels of CTA in EtOH-sensitized and nonsensitized groups. CTA induced by 2 g/kg EtOH and 2 mEq/kg LiCl was attenuated in EtOH-sensitized mice compared with nonsensitized counterparts. Thus, a sensitizing regimen of EtOH preexposure resulted in both a decrease in EtOH and LiCl aversion and an increase in EtOH locomotor sensitivity: such changes could ultimately contribute to enhanced EtOH intake and potentially to EtOH abuse.

Original languageEnglish (US)
Pages (from-to)146-153
Number of pages8
JournalBehavioral Neuroscience
Volume115
Issue number1
DOIs
StatePublished - Jan 1 2001

ASJC Scopus subject areas

  • Behavioral Neuroscience

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