Abstract
Cobaloxime-catalyzed cross coupling of styrene with 6α-bromopenicillanic acid pivalolyl-oxymethyl ester (4) introduces a styryl group into the 6 position of the penicillanic acid nucleus. The method should be capable of introducing a variety of aryl-substituted alkenes into the 6 position. Such compounds may be useful as novel β-lactam antibiotics/β-lactamase inhibitors.
Original language | English (US) |
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Pages (from-to) | 2289-2292 |
Number of pages | 4 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 6 |
Issue number | 19 |
DOIs | |
State | Published - Oct 8 1996 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry