Atrial contraction and mitral annular dynamics during acute left atrial and ventricular ischemia in sheep

Tomasz A. Timek, David T. Lai, Frederick (Fred) Tibayan, George T. Daughters, David Liang, Paul Dagum, Sidney Lo, D. Craig Miller, Neil B. Ingels

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

In six sheep, radiopaque markers were placed on the left ventricle (LV), the mitral annulus, the left atrium (LA), and the central edge of both mitral leaflets to investigate the effects of acute LV ischemia on atrial contraction, mitral annular area (MAA), and mitral regurgitation (MR). Animals were studied with biplane videofluoroscopy and transesophageal echocardiography before and during balloon occlusion of the left anterior descending (LAD), distal circumflex (dLCX), and proximal circumflex (pLCX) coronary arteries. MAA and LA area were calculated from the corresponding markers. LAD occlusion did not alter LA area reduction or presystolic MAA reduction, whereas dLCX occlusion resulted in a mild decrease in the former with no change in the latter. Neither occlusion resulted in MR. pLCX occlusion, however, significantly decreased LA area and presystolic MAA reduction and resulted in increased end-diastolic MAA, delayed valve closure from end diastole, and MR. Decreased atrial contractile function, as observed during acute posterolateral ischemia, is linked to diminished presystolic mitral annular reduction, a larger mitral annular size at end diastole, and MR.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume283
Issue number5 52-5
StatePublished - Nov 1 2002
Externally publishedYes

Fingerprint

Mitral Valve Insufficiency
Heart Atria
Sheep
Ischemia
Diastole
Heart Ventricles
Atrial Function
Balloon Occlusion
Transesophageal Echocardiography
Coronary Vessels

Keywords

  • Left ventricular ischemia
  • Mitral annulus
  • Mitral regurgitation

ASJC Scopus subject areas

  • Physiology

Cite this

Atrial contraction and mitral annular dynamics during acute left atrial and ventricular ischemia in sheep. / Timek, Tomasz A.; Lai, David T.; Tibayan, Frederick (Fred); Daughters, George T.; Liang, David; Dagum, Paul; Lo, Sidney; Craig Miller, D.; Ingels, Neil B.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 283, No. 5 52-5, 01.11.2002.

Research output: Contribution to journalArticle

Timek, TA, Lai, DT, Tibayan, FF, Daughters, GT, Liang, D, Dagum, P, Lo, S, Craig Miller, D & Ingels, NB 2002, 'Atrial contraction and mitral annular dynamics during acute left atrial and ventricular ischemia in sheep', American Journal of Physiology - Heart and Circulatory Physiology, vol. 283, no. 5 52-5.
Timek, Tomasz A. ; Lai, David T. ; Tibayan, Frederick (Fred) ; Daughters, George T. ; Liang, David ; Dagum, Paul ; Lo, Sidney ; Craig Miller, D. ; Ingels, Neil B. / Atrial contraction and mitral annular dynamics during acute left atrial and ventricular ischemia in sheep. In: American Journal of Physiology - Heart and Circulatory Physiology. 2002 ; Vol. 283, No. 5 52-5.
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