ATP analogs with non-transferable groups in the γ position as inhibitors of glycerol kinase

Cory E. Bystrom, Donald W. Pettigrew, S. James Remington, Bruce Branchaud

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

β,γ-Difluoromethyleneadenosine-5'-triphos (AMP-PCF2P, 3) and γ-arsono-β,γ-methyleneadenosined'-diphosphate (AMP-PCAs, 4) were synthesized and were found to be competitive inhibitors of glycerolkinase. Commercially available AMP-PCP and AMP-PNP also are competitive inhibitors. The structural similarities and differences of these ATP analogs and their effect on kinase inhibition are discussed.

Original languageEnglish (US)
Pages (from-to)2613-2616
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume7
Issue number20
DOIs
StatePublished - Oct 21 1997
Externally publishedYes

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Glycerol Kinase
Adenosine Monophosphate
Adenosine Triphosphate
Adenylyl Imidodiphosphate
Passive Cutaneous Anaphylaxis
Diphosphates
Phosphotransferases

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

ATP analogs with non-transferable groups in the γ position as inhibitors of glycerol kinase. / Bystrom, Cory E.; Pettigrew, Donald W.; Remington, S. James; Branchaud, Bruce.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 7, No. 20, 21.10.1997, p. 2613-2616.

Research output: Contribution to journalArticle

Bystrom, Cory E. ; Pettigrew, Donald W. ; Remington, S. James ; Branchaud, Bruce. / ATP analogs with non-transferable groups in the γ position as inhibitors of glycerol kinase. In: Bioorganic and Medicinal Chemistry Letters. 1997 ; Vol. 7, No. 20. pp. 2613-2616.
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