Abstract
β,γ-Difluoromethyleneadenosine-5'-triphos (AMP-PCF2P, 3) and γ-arsono-β,γ-methyleneadenosined'-diphosphate (AMP-PCAs, 4) were synthesized and were found to be competitive inhibitors of glycerolkinase. Commercially available AMP-PCP and AMP-PNP also are competitive inhibitors. The structural similarities and differences of these ATP analogs and their effect on kinase inhibition are discussed.
Original language | English (US) |
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Pages (from-to) | 2613-2616 |
Number of pages | 4 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 7 |
Issue number | 20 |
DOIs | |
State | Published - Oct 21 1997 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry