Atopy in people aged 40 years and over

Relation to airflow limitation

E. M. Guevara-Rattray, F. L. Garden, A. L. James, R. Wood-Baker, M. J. Abramson, D. P. Johns, A (Sonia) Buist, P. G.J. Burney, E. Haydn Walters, B. G. Toelle, G. B. Marks

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Previous studies have reached conflicting conclusions about the role of atopy as a risk factor for COPD. In part, this is attributable to variation in the definitions of airflow limitation and the treatment of people with asthma. Objective: To establish whether there is any independent association between atopy and post-bronchodilator airflow limitation in the general population aged 40 years and over. Methods: A cross-sectional survey was conducted in a general population sample of 2415 people aged 40 years and over in Australia. A history of ever being diagnosed with asthma was elicited by questionnaire. Atopy was defined as any skin prick test weal to common aeroallergens ≥4 mm. Airflow limitation was defined as post-bronchodilator spirometric (FEV1/FVC) ratio <lower limit of normal. Analyses were adjusted for potential confounding due to age, sex, smoking, race and socio-economic status. Results: The prevalence of atopy, ever diagnosed asthma and post-bronchodilator airflow obstruction was 44.8%, 19.3% and 7.5%, respectively. In the population as a whole, atopy was associated with lower FEV₁ (adjusted difference −0.068L, 95% confidence interval (CI) −0.104 to −0.032), FVC (adj. difference −0.043L, 95% CI −0.086 to −0.0009) and post-bronchodilator FEV₁/FVC ratio (adj. difference −0.011, 95% CI −0.017 to −0.0055). The effect of atopy on lung function was no longer apparent when participants who reported ever diagnosed asthma were excluded (FEV₁ −0.011L, [95% CI −0.05 to 0.028L], FVC −0.012L [95% CI −0.060 to 0.036] and FEV₁/FVC ratio −0.0012 [95% CI −0.0072 to 0.0047L]). Conclusion and Clinical Relevance: The apparent association between atopy and post-bronchodilator airflow limitation in the general population appears to be explained by the association between atopy and having ever diagnosed asthma and the effect of asthma on lung function.

Original languageEnglish (US)
Pages (from-to)1625-1630
Number of pages6
JournalClinical and Experimental Allergy
Volume47
Issue number12
DOIs
StatePublished - Dec 1 2017

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Bronchodilator Agents
Asthma
Confidence Intervals
Population
Lung
Skin Tests
Chronic Obstructive Pulmonary Disease
Cross-Sectional Studies
Smoking
Economics

Keywords

  • airflow limitation
  • allergic sensitization
  • asthma
  • atopy
  • COPD
  • epidemiology
  • population health

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Guevara-Rattray, E. M., Garden, F. L., James, A. L., Wood-Baker, R., Abramson, M. J., Johns, D. P., ... Marks, G. B. (2017). Atopy in people aged 40 years and over: Relation to airflow limitation. Clinical and Experimental Allergy, 47(12), 1625-1630. https://doi.org/10.1111/cea.13038

Atopy in people aged 40 years and over : Relation to airflow limitation. / Guevara-Rattray, E. M.; Garden, F. L.; James, A. L.; Wood-Baker, R.; Abramson, M. J.; Johns, D. P.; Buist, A (Sonia); Burney, P. G.J.; Haydn Walters, E.; Toelle, B. G.; Marks, G. B.

In: Clinical and Experimental Allergy, Vol. 47, No. 12, 01.12.2017, p. 1625-1630.

Research output: Contribution to journalArticle

Guevara-Rattray, EM, Garden, FL, James, AL, Wood-Baker, R, Abramson, MJ, Johns, DP, Buist, AS, Burney, PGJ, Haydn Walters, E, Toelle, BG & Marks, GB 2017, 'Atopy in people aged 40 years and over: Relation to airflow limitation', Clinical and Experimental Allergy, vol. 47, no. 12, pp. 1625-1630. https://doi.org/10.1111/cea.13038
Guevara-Rattray EM, Garden FL, James AL, Wood-Baker R, Abramson MJ, Johns DP et al. Atopy in people aged 40 years and over: Relation to airflow limitation. Clinical and Experimental Allergy. 2017 Dec 1;47(12):1625-1630. https://doi.org/10.1111/cea.13038
Guevara-Rattray, E. M. ; Garden, F. L. ; James, A. L. ; Wood-Baker, R. ; Abramson, M. J. ; Johns, D. P. ; Buist, A (Sonia) ; Burney, P. G.J. ; Haydn Walters, E. ; Toelle, B. G. ; Marks, G. B. / Atopy in people aged 40 years and over : Relation to airflow limitation. In: Clinical and Experimental Allergy. 2017 ; Vol. 47, No. 12. pp. 1625-1630.
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