Atopic Dermatitis: Epidemiology and Pathogenesis Update

Lawrence F. Eichenfield, Charles N. Ellis, Anthony J. Mancini, Amy S. Paller, Eric L. Simpson

Research output: Contribution to journalReview articlepeer-review

55 Scopus citations


The prevalence of atopic dermatitis (AD) has increased markedly in the United States over the past 5 decades, with current reports varying from 10% to 20% prevalence in US children, and new diagnoses are estimated at almost 11% per year. Recent research in AD pathophysiology and pathogenesis has demonstrated that AD is associated with epidermal barrier dysfunction and that mutations in the filaggrin gene are implicated in barrier defects. These discoveries hold promise for future breakthroughs in the diagnosis and management of AD.

Original languageEnglish (US)
Pages (from-to)S3-S5
JournalSeminars in cutaneous medicine and surgery
Issue number3 SUPPL.
StatePublished - Sep 2012


  • Atopic dermatitis pathogenesis
  • Barrier defects
  • Epidermal skin barrier
  • Filaggrin gene

ASJC Scopus subject areas

  • Surgery
  • Dermatology


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