Atopic dermatitis

M. A. Brown; J. M. Hanifin

doi:10.1016/0952-7915(90)90006-3

Atopic dermatitis

M. A. Brown, J. M. Hanifin

Dermatology

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

AD is a complex, multifactorial, cutaneous manifestation of the atopic diathesis. Observations from bone marrow transplantation cases have shown transmission of the disease from atopic donors [30] and indicate that the basic defect is carried in immune and inflammatory cells which infiltrate skin lesions. Mast cells appear to be important in the initiation of inflammatory events and eosinophils may have an important role in perpetuating the response. New evidence suggests that IL-4 may be a crucial factor controlling mast cells as well as IgE production in allergic disease. The significance of the FCεRII/CD23 in regulating IgE synthesis and its role in Langerhans' cell/antigen interactions in atopic dermatitis represents an intriguing area in need of further study.

Original language	English (US)
Pages (from-to)	531-534
Number of pages	4
Journal	Current opinion in immunology
Volume	2
Issue number	4
DOIs	https://doi.org/10.1016/0952-7915(90)90006-3
State	Published - Apr 1990

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/0952-7915(90)90006-3

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title = "Atopic dermatitis",

abstract = "AD is a complex, multifactorial, cutaneous manifestation of the atopic diathesis. Observations from bone marrow transplantation cases have shown transmission of the disease from atopic donors [30] and indicate that the basic defect is carried in immune and inflammatory cells which infiltrate skin lesions. Mast cells appear to be important in the initiation of inflammatory events and eosinophils may have an important role in perpetuating the response. New evidence suggests that IL-4 may be a crucial factor controlling mast cells as well as IgE production in allergic disease. The significance of the FCεRII/CD23 in regulating IgE synthesis and its role in Langerhans' cell/antigen interactions in atopic dermatitis represents an intriguing area in need of further study.",

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AU - Brown, M. A.

AU - Hanifin, J. M.

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AB - AD is a complex, multifactorial, cutaneous manifestation of the atopic diathesis. Observations from bone marrow transplantation cases have shown transmission of the disease from atopic donors [30] and indicate that the basic defect is carried in immune and inflammatory cells which infiltrate skin lesions. Mast cells appear to be important in the initiation of inflammatory events and eosinophils may have an important role in perpetuating the response. New evidence suggests that IL-4 may be a crucial factor controlling mast cells as well as IgE production in allergic disease. The significance of the FCεRII/CD23 in regulating IgE synthesis and its role in Langerhans' cell/antigen interactions in atopic dermatitis represents an intriguing area in need of further study.

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Atopic dermatitis

Abstract

ASJC Scopus subject areas

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