Atopic dermatitis

M. A. Brown, Jon Hanifin

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

AD is a complex, multifactorial, cutaneous manifestation of the atopic diathesis. Observations from bone marrow transplantation cases have shown transmission of the disease from atopic donors [30] and indicate that the basic defect is carried in immune and inflammatory cells which infiltrate skin lesions. Mast cells appear to be important in the initiation of inflammatory events and eosinophils may have an important role in perpetuating the response. New evidence suggests that IL-4 may be a crucial factor controlling mast cells as well as IgE production in allergic disease. The significance of the FCεRII/CD23 in regulating IgE synthesis and its role in Langerhans' cell/antigen interactions in atopic dermatitis represents an intriguing area in need of further study.

Original languageEnglish (US)
Pages (from-to)531-534
Number of pages4
JournalCurrent Opinion in Immunology
Volume2
Issue number4
DOIs
StatePublished - 1990

Fingerprint

Atopic Dermatitis
Mast Cells
Immunoglobulin E
Skin Manifestations
Langerhans Cells
Disease Susceptibility
Bone Marrow Transplantation
Eosinophils
Cell Communication
Interleukin-4
Antigens
Skin

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Atopic dermatitis. / Brown, M. A.; Hanifin, Jon.

In: Current Opinion in Immunology, Vol. 2, No. 4, 1990, p. 531-534.

Research output: Contribution to journalArticle

Brown, M. A. ; Hanifin, Jon. / Atopic dermatitis. In: Current Opinion in Immunology. 1990 ; Vol. 2, No. 4. pp. 531-534.
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