At the interface of sensory and motor dysfunctions and Alzheimer's disease

Mark W. Albers; Grover C. Gilmore; Jeffrey Kaye; Claire Murphy; Arthur Wingfield; David A. Bennett; Adam L. Boxer; Aron S. Buchman; Karen J. Cruickshanks; Davangere P. Devanand; Charles J. Duffy; Christine M. Gall; George A. Gates; Ann Charlotte Granholm; Takao Hensch; Roee Holtzer; Bradley T. Hyman; Frank R. Lin; Ann C. McKee; John C. Morris; Ronald C. Petersen; Lisa C. Silbert; Robert G. Struble; John Q. Trojanowski; Joe Verghese; Donald A. Wilson; Shunbin Xu; Li I. Zhang

doi:10.1016/j.jalz.2014.04.514

At the interface of sensory and motor dysfunctions and Alzheimer's disease

Mark W. Albers, Grover C. Gilmore, Jeffrey Kaye, Claire Murphy, Arthur Wingfield, David A. Bennett, Adam L. Boxer, Aron S. Buchman, Karen J. Cruickshanks, Davangere P. Devanand, Charles J. Duffy, Christine M. Gall, George A. Gates, Ann Charlotte Granholm, Takao Hensch, Roee Holtzer, Bradley T. Hyman, Frank R. Lin, Ann C. McKee, John C. MorrisRonald C. Petersen, Lisa C. Silbert, Robert G. Struble, John Q. Trojanowski, Joe Verghese, Donald A. Wilson, Shunbin Xu, Li I. Zhang

Neurology

Research output: Contribution to journal › Review article › peer-review

391 Scopus citations

Abstract

Recent evidence indicates that sensory and motor changes may precede the cognitive symptoms of Alzheimer's disease (AD) by several years and may signify increased risk of developing AD. Traditionally, sensory and motor dysfunctions in aging and AD have been studied separately. To ascertain the evidence supporting the relationship between age-related changes in sensory and motor systems and the development of AD and to facilitate communication between several disciplines, the National Institute on Aging held an exploratory workshop titled "Sensory and Motor Dysfunctions in Aging and AD." The scientific sessions of the workshop focused on age-related and neuropathologic changes in the olfactory, visual, auditory, and motor systems, followed by extensive discussion and hypothesis generation related to the possible links among sensory, cognitive, and motor domains in aging and AD. Based on the data presented and discussed at this workshop, it is clear that sensory and motor regions of the central nervous system are affected by AD pathology and that interventions targeting amelioration of sensory-motor deficits in AD may enhance patient function as AD progresses.

Original language	English (US)
Pages (from-to)	70-98
Number of pages	29
Journal	Alzheimer's and Dementia
Volume	11
Issue number	1
DOIs	https://doi.org/10.1016/j.jalz.2014.04.514
State	Published - 2015

Keywords

Aging
Alzheimer's disease
Auditory function
Motor
Olfaction
Vision

ASJC Scopus subject areas

Epidemiology
Health Policy
Developmental Neuroscience
Clinical Neurology
Geriatrics and Gerontology
Cellular and Molecular Neuroscience
Psychiatry and Mental health

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10.1016/j.jalz.2014.04.514

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Albers, M. W., Gilmore, G. C., Kaye, J., Murphy, C., Wingfield, A., Bennett, D. A., Boxer, A. L., Buchman, A. S., Cruickshanks, K. J., Devanand, D. P., Duffy, C. J., Gall, C. M., Gates, G. A., Granholm, A. C., Hensch, T., Holtzer, R., Hyman, B. T., Lin, F. R., McKee, A. C., ... Zhang, L. I. (2015). At the interface of sensory and motor dysfunctions and Alzheimer's disease. Alzheimer's and Dementia, 11(1), 70-98. https://doi.org/10.1016/j.jalz.2014.04.514

Albers, MW, Gilmore, GC, Kaye, J, Murphy, C, Wingfield, A, Bennett, DA, Boxer, AL, Buchman, AS, Cruickshanks, KJ, Devanand, DP, Duffy, CJ, Gall, CM, Gates, GA, Granholm, AC, Hensch, T, Holtzer, R, Hyman, BT, Lin, FR, McKee, AC, Morris, JC, Petersen, RC, Silbert, LC, Struble, RG, Trojanowski, JQ, Verghese, J, Wilson, DA, Xu, S & Zhang, LI 2015, 'At the interface of sensory and motor dysfunctions and Alzheimer's disease', Alzheimer's and Dementia, vol. 11, no. 1, pp. 70-98. https://doi.org/10.1016/j.jalz.2014.04.514

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abstract = "Recent evidence indicates that sensory and motor changes may precede the cognitive symptoms of Alzheimer's disease (AD) by several years and may signify increased risk of developing AD. Traditionally, sensory and motor dysfunctions in aging and AD have been studied separately. To ascertain the evidence supporting the relationship between age-related changes in sensory and motor systems and the development of AD and to facilitate communication between several disciplines, the National Institute on Aging held an exploratory workshop titled {"}Sensory and Motor Dysfunctions in Aging and AD.{"} The scientific sessions of the workshop focused on age-related and neuropathologic changes in the olfactory, visual, auditory, and motor systems, followed by extensive discussion and hypothesis generation related to the possible links among sensory, cognitive, and motor domains in aging and AD. Based on the data presented and discussed at this workshop, it is clear that sensory and motor regions of the central nervous system are affected by AD pathology and that interventions targeting amelioration of sensory-motor deficits in AD may enhance patient function as AD progresses.",

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AU - Gilmore, Grover C.

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AU - Murphy, Claire

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AU - Bennett, David A.

AU - Boxer, Adam L.

AU - Buchman, Aron S.

AU - Cruickshanks, Karen J.

AU - Devanand, Davangere P.

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AU - Gates, George A.

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AU - Holtzer, Roee

AU - Hyman, Bradley T.

AU - Lin, Frank R.

AU - McKee, Ann C.

AU - Morris, John C.

AU - Petersen, Ronald C.

AU - Silbert, Lisa C.

AU - Struble, Robert G.

AU - Trojanowski, John Q.

AU - Verghese, Joe

AU - Wilson, Donald A.

AU - Xu, Shunbin

AU - Zhang, Li I.

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AB - Recent evidence indicates that sensory and motor changes may precede the cognitive symptoms of Alzheimer's disease (AD) by several years and may signify increased risk of developing AD. Traditionally, sensory and motor dysfunctions in aging and AD have been studied separately. To ascertain the evidence supporting the relationship between age-related changes in sensory and motor systems and the development of AD and to facilitate communication between several disciplines, the National Institute on Aging held an exploratory workshop titled "Sensory and Motor Dysfunctions in Aging and AD." The scientific sessions of the workshop focused on age-related and neuropathologic changes in the olfactory, visual, auditory, and motor systems, followed by extensive discussion and hypothesis generation related to the possible links among sensory, cognitive, and motor domains in aging and AD. Based on the data presented and discussed at this workshop, it is clear that sensory and motor regions of the central nervous system are affected by AD pathology and that interventions targeting amelioration of sensory-motor deficits in AD may enhance patient function as AD progresses.

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At the interface of sensory and motor dysfunctions and Alzheimer's disease

Abstract

Keywords

ASJC Scopus subject areas

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