At the interface of sensory and motor dysfunctions and Alzheimer's disease

Mark W. Albers, Grover C. Gilmore, Jeffrey Kaye, Claire Murphy, Arthur Wingfield, David A. Bennett, Adam L. Boxer, Aron S. Buchman, Karen J. Cruickshanks, Davangere P. Devanand, Charles J. Duffy, Christine M. Gall, George A. Gates, Ann Charlotte Granholm, Takao Hensch, Roee Holtzer, Bradley T. Hyman, Frank R. Lin, Ann C. McKee, John C. MorrisRonald C. Petersen, Lisa Silbert, Robert G. Struble, John Q. Trojanowski, Joe Verghese, Donald A. Wilson, Shunbin Xu, Li I. Zhang

Research output: Contribution to journalArticle

144 Citations (Scopus)

Abstract

Recent evidence indicates that sensory and motor changes may precede the cognitive symptoms of Alzheimer's disease (AD) by several years and may signify increased risk of developing AD. Traditionally, sensory and motor dysfunctions in aging and AD have been studied separately. To ascertain the evidence supporting the relationship between age-related changes in sensory and motor systems and the development of AD and to facilitate communication between several disciplines, the National Institute on Aging held an exploratory workshop titled "Sensory and Motor Dysfunctions in Aging and AD." The scientific sessions of the workshop focused on age-related and neuropathologic changes in the olfactory, visual, auditory, and motor systems, followed by extensive discussion and hypothesis generation related to the possible links among sensory, cognitive, and motor domains in aging and AD. Based on the data presented and discussed at this workshop, it is clear that sensory and motor regions of the central nervous system are affected by AD pathology and that interventions targeting amelioration of sensory-motor deficits in AD may enhance patient function as AD progresses.

Original languageEnglish (US)
Pages (from-to)70-98
Number of pages29
JournalAlzheimer's and Dementia
Volume11
Issue number1
DOIs
StatePublished - 2015

Fingerprint

Alzheimer Disease
Education
National Institute on Aging (U.S.)
Neurobehavioral Manifestations
Central Nervous System
Communication
Pathology

Keywords

  • Aging
  • Alzheimer's disease
  • Auditory function
  • Motor
  • Olfaction
  • Vision

ASJC Scopus subject areas

  • Clinical Neurology
  • Developmental Neuroscience
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Epidemiology
  • Health Policy

Cite this

Albers, M. W., Gilmore, G. C., Kaye, J., Murphy, C., Wingfield, A., Bennett, D. A., ... Zhang, L. I. (2015). At the interface of sensory and motor dysfunctions and Alzheimer's disease. Alzheimer's and Dementia, 11(1), 70-98. https://doi.org/10.1016/j.jalz.2014.04.514

At the interface of sensory and motor dysfunctions and Alzheimer's disease. / Albers, Mark W.; Gilmore, Grover C.; Kaye, Jeffrey; Murphy, Claire; Wingfield, Arthur; Bennett, David A.; Boxer, Adam L.; Buchman, Aron S.; Cruickshanks, Karen J.; Devanand, Davangere P.; Duffy, Charles J.; Gall, Christine M.; Gates, George A.; Granholm, Ann Charlotte; Hensch, Takao; Holtzer, Roee; Hyman, Bradley T.; Lin, Frank R.; McKee, Ann C.; Morris, John C.; Petersen, Ronald C.; Silbert, Lisa; Struble, Robert G.; Trojanowski, John Q.; Verghese, Joe; Wilson, Donald A.; Xu, Shunbin; Zhang, Li I.

In: Alzheimer's and Dementia, Vol. 11, No. 1, 2015, p. 70-98.

Research output: Contribution to journalArticle

Albers, MW, Gilmore, GC, Kaye, J, Murphy, C, Wingfield, A, Bennett, DA, Boxer, AL, Buchman, AS, Cruickshanks, KJ, Devanand, DP, Duffy, CJ, Gall, CM, Gates, GA, Granholm, AC, Hensch, T, Holtzer, R, Hyman, BT, Lin, FR, McKee, AC, Morris, JC, Petersen, RC, Silbert, L, Struble, RG, Trojanowski, JQ, Verghese, J, Wilson, DA, Xu, S & Zhang, LI 2015, 'At the interface of sensory and motor dysfunctions and Alzheimer's disease', Alzheimer's and Dementia, vol. 11, no. 1, pp. 70-98. https://doi.org/10.1016/j.jalz.2014.04.514
Albers, Mark W. ; Gilmore, Grover C. ; Kaye, Jeffrey ; Murphy, Claire ; Wingfield, Arthur ; Bennett, David A. ; Boxer, Adam L. ; Buchman, Aron S. ; Cruickshanks, Karen J. ; Devanand, Davangere P. ; Duffy, Charles J. ; Gall, Christine M. ; Gates, George A. ; Granholm, Ann Charlotte ; Hensch, Takao ; Holtzer, Roee ; Hyman, Bradley T. ; Lin, Frank R. ; McKee, Ann C. ; Morris, John C. ; Petersen, Ronald C. ; Silbert, Lisa ; Struble, Robert G. ; Trojanowski, John Q. ; Verghese, Joe ; Wilson, Donald A. ; Xu, Shunbin ; Zhang, Li I. / At the interface of sensory and motor dysfunctions and Alzheimer's disease. In: Alzheimer's and Dementia. 2015 ; Vol. 11, No. 1. pp. 70-98.
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