Asynchronous regional brain volume losses in presymptomatic to moderate AD

Jeffrey Kaye, M. M. Moore, A. Dame, Joseph Quinn, R. Camicioli, Diane Howieson, E. Corbridge, B. Care, Gary Nesbit, G. Sexton

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

To determine if rates and locations of brain volume loss associated with AD are phase-specific, occurring prior to clinical onset and at later stages, we performed longitudinal volumetric MRI analysis on 155 subjects enrolled in a prospective study of aging and dementia. Subjects were divided by Clinical Dementia Rating (CDR) scale into stages of Normal (CDR 0 → 0), Very Mild (CDR 0 → 0.5 and 0.5 → 0.5), Mild (CDR 0.5 → 1.0 and 1.0 → 1.0) and Moderate (CDR 1.0 → 2.0 and 2.0 → 2.0) dementia. Rates of volume change in CSF spaces, lobar and medial temporal lobe regions were analyzed for group differences across stages. Annual rates of ventricular volume change differed between non-demented and very mild group (p

Original languageEnglish (US)
Pages (from-to)51-56
Number of pages6
JournalJournal of Alzheimer's Disease
Volume8
Issue number1
StatePublished - 2005

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Dementia
Brain
Temporal Lobe
Prospective Studies

Keywords

  • Aging
  • Alzheimer disease
  • Dementia
  • MRI
  • Oldest-old

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology

Cite this

Kaye, J., Moore, M. M., Dame, A., Quinn, J., Camicioli, R., Howieson, D., ... Sexton, G. (2005). Asynchronous regional brain volume losses in presymptomatic to moderate AD. Journal of Alzheimer's Disease, 8(1), 51-56.

Asynchronous regional brain volume losses in presymptomatic to moderate AD. / Kaye, Jeffrey; Moore, M. M.; Dame, A.; Quinn, Joseph; Camicioli, R.; Howieson, Diane; Corbridge, E.; Care, B.; Nesbit, Gary; Sexton, G.

In: Journal of Alzheimer's Disease, Vol. 8, No. 1, 2005, p. 51-56.

Research output: Contribution to journalArticle

Kaye, J, Moore, MM, Dame, A, Quinn, J, Camicioli, R, Howieson, D, Corbridge, E, Care, B, Nesbit, G & Sexton, G 2005, 'Asynchronous regional brain volume losses in presymptomatic to moderate AD', Journal of Alzheimer's Disease, vol. 8, no. 1, pp. 51-56.
Kaye, Jeffrey ; Moore, M. M. ; Dame, A. ; Quinn, Joseph ; Camicioli, R. ; Howieson, Diane ; Corbridge, E. ; Care, B. ; Nesbit, Gary ; Sexton, G. / Asynchronous regional brain volume losses in presymptomatic to moderate AD. In: Journal of Alzheimer's Disease. 2005 ; Vol. 8, No. 1. pp. 51-56.
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