TY - JOUR
T1 - Astrocytes conspire with neurons during progression of neurological disease
AU - McGann, James C.
AU - Lioy, Daniel T.
AU - Mandel, Gail
N1 - Funding Information:
The authors would like to thank Dr. Nurit Ballas and Dr. Paul Barnes for comments on the manuscript and grants from the NIH and Rett Syndrome Research Trust to GM. GM is an Investigator of the Howard Hughes Medical Institute.
PY - 2012/10
Y1 - 2012/10
N2 - As astrocytes are becoming recognized as important mediators of normal brain function, studies into their roles in neurological disease have gained significance. Across mouse models for neurodevelopmental and neurodegenerative diseases, astrocytes are considered key regulators of disease progression. In Rett syndrome and Parkinson's disease, astrocytes can even initiate certain disease phenotypes. Numerous potential mechanisms have been offered to explain these results, but research into the functions of astrocytes in disease is just beginning. Crucially, in vivo verification of in vitro data is still necessary, as well as a deeper understanding of the complex and relatively unexplored interactions between astrocytes, oligodendrocytes, microglia, and neurons.
AB - As astrocytes are becoming recognized as important mediators of normal brain function, studies into their roles in neurological disease have gained significance. Across mouse models for neurodevelopmental and neurodegenerative diseases, astrocytes are considered key regulators of disease progression. In Rett syndrome and Parkinson's disease, astrocytes can even initiate certain disease phenotypes. Numerous potential mechanisms have been offered to explain these results, but research into the functions of astrocytes in disease is just beginning. Crucially, in vivo verification of in vitro data is still necessary, as well as a deeper understanding of the complex and relatively unexplored interactions between astrocytes, oligodendrocytes, microglia, and neurons.
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U2 - 10.1016/j.conb.2012.03.009
DO - 10.1016/j.conb.2012.03.009
M3 - Review article
C2 - 22475461
AN - SCOPUS:84868194710
SN - 0959-4388
VL - 22
SP - 850
EP - 858
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
IS - 5
ER -