Associations of obesity with triglycerides and C-reactive protein are attenuated in adults with high red blood cell eicosapentaenoic and docosahexaenoic acids

Z. Makhoul, A. R. Kristal, R. Gulati, B. Luick, A. Bersamin, D. O'Brien, S. E. Hopkins, C. B. Stephensen, K. L. Stanhope, P. J. Havel, Bert Boyer

Research output: Contribution to journalArticle

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Abstract

Background:N-3 fatty acids are associated with favorable, and obesity with unfavorable, concentrations of chronic disease risk biomarkers.Objective:We examined whether high eicosapentaenoic (EPA) and docosahexaenoic (DHA) acid intakes, measured as percentages of total red blood cell (RBC) fatty acids, modify associations of obesity with chronic disease risk biomarkers.Methods:In a cross-sectional study of 330 Yupik Eskimos, generalized additive models (GAM) and linear and quadratic regression models were used to examine associations of BMI with biomarkers across RBC EPA and DHA categories.Results:Median (5th-95th percentile) RBC EPA and DHA were 2.6% (0.5-5.9%) and 7.3% (3.3-8.9%), respectively. In regression models, associations of BMI with triglycerides, glucose, insulin, C-reactive protein (CRP) and leptin differed significantly by RBC EPA and DHA. The GAM confirmed regression results for triglycerides and CRP: at low RBC EPA and RBC DHA, the predicted increases in triglycerides and CRP concentrations associated with a BMI increase from 25 to 35 were 99.545.3 mg/dl (106%) and 137.871.0 mg/dl (156%), respectively, for triglycerides and 1.20.7 mg/l (61%) and 0.81.0 mg/l (35%), respectively, for CRP. At high RBC EPA and RBC DHA, these predicted increases were 13.98.1 mg/dl (23%) and 12.012.3 mg/dl (18%), respectively, for triglycerides and 0.50.5 mg/l (50%) and 0.50.6 mg/l (34%), respectively, for CRP.Conclusions:In this population, high RBC EPA and DHA were associated with attenuated dyslipidemia and low-grade systemic inflammation among overweight and obese persons. This may help inform recommendations for n-3 fatty acid intakes in the reduction of obesity-related disease risk.

Original languageEnglish (US)
Pages (from-to)808-817
Number of pages10
JournalEuropean Journal of Clinical Nutrition
Volume65
Issue number7
DOIs
StatePublished - Jul 1 2011
Externally publishedYes

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Eicosapentaenoic Acid
Docosahexaenoic Acids
C-Reactive Protein
Triglycerides
Obesity
Erythrocytes
Biomarkers
Omega-3 Fatty Acids
Chronic Disease
Inuits
Dyslipidemias
Leptin
Linear Models
Fatty Acids
Cross-Sectional Studies
Insulin
Inflammation
Glucose

Keywords

  • C-reactive protein
  • DHA
  • EPA
  • generalized additive models
  • triglycerides
  • Yupik Eskimos

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Associations of obesity with triglycerides and C-reactive protein are attenuated in adults with high red blood cell eicosapentaenoic and docosahexaenoic acids. / Makhoul, Z.; Kristal, A. R.; Gulati, R.; Luick, B.; Bersamin, A.; O'Brien, D.; Hopkins, S. E.; Stephensen, C. B.; Stanhope, K. L.; Havel, P. J.; Boyer, Bert.

In: European Journal of Clinical Nutrition, Vol. 65, No. 7, 01.07.2011, p. 808-817.

Research output: Contribution to journalArticle

Makhoul, Z, Kristal, AR, Gulati, R, Luick, B, Bersamin, A, O'Brien, D, Hopkins, SE, Stephensen, CB, Stanhope, KL, Havel, PJ & Boyer, B 2011, 'Associations of obesity with triglycerides and C-reactive protein are attenuated in adults with high red blood cell eicosapentaenoic and docosahexaenoic acids', European Journal of Clinical Nutrition, vol. 65, no. 7, pp. 808-817. https://doi.org/10.1038/ejcn.2011.39
Makhoul, Z. ; Kristal, A. R. ; Gulati, R. ; Luick, B. ; Bersamin, A. ; O'Brien, D. ; Hopkins, S. E. ; Stephensen, C. B. ; Stanhope, K. L. ; Havel, P. J. ; Boyer, Bert. / Associations of obesity with triglycerides and C-reactive protein are attenuated in adults with high red blood cell eicosapentaenoic and docosahexaenoic acids. In: European Journal of Clinical Nutrition. 2011 ; Vol. 65, No. 7. pp. 808-817.
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T1 - Associations of obesity with triglycerides and C-reactive protein are attenuated in adults with high red blood cell eicosapentaenoic and docosahexaenoic acids

AU - Makhoul, Z.

AU - Kristal, A. R.

AU - Gulati, R.

AU - Luick, B.

AU - Bersamin, A.

AU - O'Brien, D.

AU - Hopkins, S. E.

AU - Stephensen, C. B.

AU - Stanhope, K. L.

AU - Havel, P. J.

AU - Boyer, Bert

PY - 2011/7/1

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N2 - Background:N-3 fatty acids are associated with favorable, and obesity with unfavorable, concentrations of chronic disease risk biomarkers.Objective:We examined whether high eicosapentaenoic (EPA) and docosahexaenoic (DHA) acid intakes, measured as percentages of total red blood cell (RBC) fatty acids, modify associations of obesity with chronic disease risk biomarkers.Methods:In a cross-sectional study of 330 Yupik Eskimos, generalized additive models (GAM) and linear and quadratic regression models were used to examine associations of BMI with biomarkers across RBC EPA and DHA categories.Results:Median (5th-95th percentile) RBC EPA and DHA were 2.6% (0.5-5.9%) and 7.3% (3.3-8.9%), respectively. In regression models, associations of BMI with triglycerides, glucose, insulin, C-reactive protein (CRP) and leptin differed significantly by RBC EPA and DHA. The GAM confirmed regression results for triglycerides and CRP: at low RBC EPA and RBC DHA, the predicted increases in triglycerides and CRP concentrations associated with a BMI increase from 25 to 35 were 99.545.3 mg/dl (106%) and 137.871.0 mg/dl (156%), respectively, for triglycerides and 1.20.7 mg/l (61%) and 0.81.0 mg/l (35%), respectively, for CRP. At high RBC EPA and RBC DHA, these predicted increases were 13.98.1 mg/dl (23%) and 12.012.3 mg/dl (18%), respectively, for triglycerides and 0.50.5 mg/l (50%) and 0.50.6 mg/l (34%), respectively, for CRP.Conclusions:In this population, high RBC EPA and DHA were associated with attenuated dyslipidemia and low-grade systemic inflammation among overweight and obese persons. This may help inform recommendations for n-3 fatty acid intakes in the reduction of obesity-related disease risk.

AB - Background:N-3 fatty acids are associated with favorable, and obesity with unfavorable, concentrations of chronic disease risk biomarkers.Objective:We examined whether high eicosapentaenoic (EPA) and docosahexaenoic (DHA) acid intakes, measured as percentages of total red blood cell (RBC) fatty acids, modify associations of obesity with chronic disease risk biomarkers.Methods:In a cross-sectional study of 330 Yupik Eskimos, generalized additive models (GAM) and linear and quadratic regression models were used to examine associations of BMI with biomarkers across RBC EPA and DHA categories.Results:Median (5th-95th percentile) RBC EPA and DHA were 2.6% (0.5-5.9%) and 7.3% (3.3-8.9%), respectively. In regression models, associations of BMI with triglycerides, glucose, insulin, C-reactive protein (CRP) and leptin differed significantly by RBC EPA and DHA. The GAM confirmed regression results for triglycerides and CRP: at low RBC EPA and RBC DHA, the predicted increases in triglycerides and CRP concentrations associated with a BMI increase from 25 to 35 were 99.545.3 mg/dl (106%) and 137.871.0 mg/dl (156%), respectively, for triglycerides and 1.20.7 mg/l (61%) and 0.81.0 mg/l (35%), respectively, for CRP. At high RBC EPA and RBC DHA, these predicted increases were 13.98.1 mg/dl (23%) and 12.012.3 mg/dl (18%), respectively, for triglycerides and 0.50.5 mg/l (50%) and 0.50.6 mg/l (34%), respectively, for CRP.Conclusions:In this population, high RBC EPA and DHA were associated with attenuated dyslipidemia and low-grade systemic inflammation among overweight and obese persons. This may help inform recommendations for n-3 fatty acid intakes in the reduction of obesity-related disease risk.

KW - C-reactive protein

KW - DHA

KW - EPA

KW - generalized additive models

KW - triglycerides

KW - Yupik Eskimos

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