Associations of demographic and lifestyle characteristics with prostate-specific antigen (PSA) concentration and rate of PSA increase

Alan R. Kristal, Chen Chi, Catherine M. Tangen, Phyllis J. Goodman, Ruth Etzioni, Ian M. Thompson

Research output: Contribution to journalArticle

90 Citations (Scopus)

Abstract

BACKGROUND. The objective of this study was to examine whether demographic and lifestyle characteristics are associated with prostate-specific antigen (PSA) levels and the rate of PSA increase (PSA velocity). METHODS. Data for this study came from 3341 participants in the placebo arm of the Prostate Cancer Prevention Trial who, based on biopsies at the end of the study, were free of prostate carcinoma. Linear regression was used to assess associations of age, race, smoking, body mass index (BMI), physical activity, diet, and supplement use with PSA concentration during the second year of the trial, and linear mixed models were used to assess associations of these factors with PSA velocity (the percentage increase in PSA per year) during 6 years of the trial. RESULTS. Between the group of men ages 50-59 years and the group of men age 70 years and older, mean PSA increased by 0.22 ng/mL, and PSA velocity decreased by 1.2 percentage points (both P < 0.001). The PSA level among men who had a BMI ≥ 35 kg/cm2 was 0.20 ng/mL lower than the PSA level among men who had a BMI < 25 kd/cm2 (P < 0.001), but BMI was not associated with PSA velocity. PSA velocity was 1.2 percentage points higher in African-American men compared with white men (P = 0.043). Low energy intake and the use of high-dose calcium supplements were associated with significantly lower PSA velocity (both P = 0.05). Weight gain also was associated with lower PSA velocity. CONCLUSIONS. Differences in PSA concentration associated with demographic and lifestyle characteristics were small and were not likely to bias the interpretation of a single PSA test. Age, race, energy intake, calcium supplement use, and weight change were associated with substantial differences in PSA velocity, and the clinical interpretation of PSA velocity may be biased by these factors.

Original languageEnglish (US)
Pages (from-to)320-328
Number of pages9
JournalCancer
Volume106
Issue number2
DOIs
StatePublished - Jan 15 2006
Externally publishedYes

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Prostate-Specific Antigen
Life Style
Demography
Body Mass Index
Energy Intake
Linear Models
Age Groups
Calcium
African Americans

Keywords

  • Benign prostatic hyperplasia
  • Finasteride
  • High-dose calcium supplements
  • Nutrition
  • Prostate Cancer Prevention Trial
  • Prostate-specific antigen velocity
  • Weight change

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Kristal, A. R., Chi, C., Tangen, C. M., Goodman, P. J., Etzioni, R., & Thompson, I. M. (2006). Associations of demographic and lifestyle characteristics with prostate-specific antigen (PSA) concentration and rate of PSA increase. Cancer, 106(2), 320-328. https://doi.org/10.1002/cncr.21603

Associations of demographic and lifestyle characteristics with prostate-specific antigen (PSA) concentration and rate of PSA increase. / Kristal, Alan R.; Chi, Chen; Tangen, Catherine M.; Goodman, Phyllis J.; Etzioni, Ruth; Thompson, Ian M.

In: Cancer, Vol. 106, No. 2, 15.01.2006, p. 320-328.

Research output: Contribution to journalArticle

Kristal, Alan R. ; Chi, Chen ; Tangen, Catherine M. ; Goodman, Phyllis J. ; Etzioni, Ruth ; Thompson, Ian M. / Associations of demographic and lifestyle characteristics with prostate-specific antigen (PSA) concentration and rate of PSA increase. In: Cancer. 2006 ; Vol. 106, No. 2. pp. 320-328.
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abstract = "BACKGROUND. The objective of this study was to examine whether demographic and lifestyle characteristics are associated with prostate-specific antigen (PSA) levels and the rate of PSA increase (PSA velocity). METHODS. Data for this study came from 3341 participants in the placebo arm of the Prostate Cancer Prevention Trial who, based on biopsies at the end of the study, were free of prostate carcinoma. Linear regression was used to assess associations of age, race, smoking, body mass index (BMI), physical activity, diet, and supplement use with PSA concentration during the second year of the trial, and linear mixed models were used to assess associations of these factors with PSA velocity (the percentage increase in PSA per year) during 6 years of the trial. RESULTS. Between the group of men ages 50-59 years and the group of men age 70 years and older, mean PSA increased by 0.22 ng/mL, and PSA velocity decreased by 1.2 percentage points (both P < 0.001). The PSA level among men who had a BMI ≥ 35 kg/cm2 was 0.20 ng/mL lower than the PSA level among men who had a BMI < 25 kd/cm2 (P < 0.001), but BMI was not associated with PSA velocity. PSA velocity was 1.2 percentage points higher in African-American men compared with white men (P = 0.043). Low energy intake and the use of high-dose calcium supplements were associated with significantly lower PSA velocity (both P = 0.05). Weight gain also was associated with lower PSA velocity. CONCLUSIONS. Differences in PSA concentration associated with demographic and lifestyle characteristics were small and were not likely to bias the interpretation of a single PSA test. Age, race, energy intake, calcium supplement use, and weight change were associated with substantial differences in PSA velocity, and the clinical interpretation of PSA velocity may be biased by these factors.",
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AU - Kristal, Alan R.

AU - Chi, Chen

AU - Tangen, Catherine M.

AU - Goodman, Phyllis J.

AU - Etzioni, Ruth

AU - Thompson, Ian M.

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N2 - BACKGROUND. The objective of this study was to examine whether demographic and lifestyle characteristics are associated with prostate-specific antigen (PSA) levels and the rate of PSA increase (PSA velocity). METHODS. Data for this study came from 3341 participants in the placebo arm of the Prostate Cancer Prevention Trial who, based on biopsies at the end of the study, were free of prostate carcinoma. Linear regression was used to assess associations of age, race, smoking, body mass index (BMI), physical activity, diet, and supplement use with PSA concentration during the second year of the trial, and linear mixed models were used to assess associations of these factors with PSA velocity (the percentage increase in PSA per year) during 6 years of the trial. RESULTS. Between the group of men ages 50-59 years and the group of men age 70 years and older, mean PSA increased by 0.22 ng/mL, and PSA velocity decreased by 1.2 percentage points (both P < 0.001). The PSA level among men who had a BMI ≥ 35 kg/cm2 was 0.20 ng/mL lower than the PSA level among men who had a BMI < 25 kd/cm2 (P < 0.001), but BMI was not associated with PSA velocity. PSA velocity was 1.2 percentage points higher in African-American men compared with white men (P = 0.043). Low energy intake and the use of high-dose calcium supplements were associated with significantly lower PSA velocity (both P = 0.05). Weight gain also was associated with lower PSA velocity. CONCLUSIONS. Differences in PSA concentration associated with demographic and lifestyle characteristics were small and were not likely to bias the interpretation of a single PSA test. Age, race, energy intake, calcium supplement use, and weight change were associated with substantial differences in PSA velocity, and the clinical interpretation of PSA velocity may be biased by these factors.

AB - BACKGROUND. The objective of this study was to examine whether demographic and lifestyle characteristics are associated with prostate-specific antigen (PSA) levels and the rate of PSA increase (PSA velocity). METHODS. Data for this study came from 3341 participants in the placebo arm of the Prostate Cancer Prevention Trial who, based on biopsies at the end of the study, were free of prostate carcinoma. Linear regression was used to assess associations of age, race, smoking, body mass index (BMI), physical activity, diet, and supplement use with PSA concentration during the second year of the trial, and linear mixed models were used to assess associations of these factors with PSA velocity (the percentage increase in PSA per year) during 6 years of the trial. RESULTS. Between the group of men ages 50-59 years and the group of men age 70 years and older, mean PSA increased by 0.22 ng/mL, and PSA velocity decreased by 1.2 percentage points (both P < 0.001). The PSA level among men who had a BMI ≥ 35 kg/cm2 was 0.20 ng/mL lower than the PSA level among men who had a BMI < 25 kd/cm2 (P < 0.001), but BMI was not associated with PSA velocity. PSA velocity was 1.2 percentage points higher in African-American men compared with white men (P = 0.043). Low energy intake and the use of high-dose calcium supplements were associated with significantly lower PSA velocity (both P = 0.05). Weight gain also was associated with lower PSA velocity. CONCLUSIONS. Differences in PSA concentration associated with demographic and lifestyle characteristics were small and were not likely to bias the interpretation of a single PSA test. Age, race, energy intake, calcium supplement use, and weight change were associated with substantial differences in PSA velocity, and the clinical interpretation of PSA velocity may be biased by these factors.

KW - Benign prostatic hyperplasia

KW - Finasteride

KW - High-dose calcium supplements

KW - Nutrition

KW - Prostate Cancer Prevention Trial

KW - Prostate-specific antigen velocity

KW - Weight change

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