Associations of a polygenic risk score with coronary artery disease phenotypes in the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) trial

Jonathan D. Newman, Pamela S. Douglas, Ilya Zhbannikov, Maros Ferencik, Borek Foldyna, Udo Hoffmann, Svati H. Shah, Geoffrey S. Ginsburg, Michael T. Lu, Deepak Voora

Research output: Contribution to journalLetterpeer-review

Abstract

A polygenic risk score (PGS) is associated with obstructive coronary artery disease (CAD) independent of traditional risk factors. Coronary computed tomography angiography (CTA) can characterize coronary plaques, including features of highrisk CAD. However, it is unknown if a PGS is associated with obstructive CAD and high-risk CAD phenotypes in patients with symptoms suggestive of CAD.

Original languageEnglish (US)
Pages (from-to)12-15
Number of pages4
JournalAmerican heart journal
Volume252
DOIs
StatePublished - Oct 2022

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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