Associations of a polygenic risk score with coronary artery disease phenotypes in the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) trial

Jonathan D. Newman; Pamela S. Douglas; Ilya Zhbannikov; Maros Ferencik; Borek Foldyna; Udo Hoffmann; Svati H. Shah; Geoffrey S. Ginsburg; Michael T. Lu; Deepak Voora

doi:10.1016/j.ahj.2022.05.012

Associations of a polygenic risk score with coronary artery disease phenotypes in the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) trial

Jonathan D. Newman, Pamela S. Douglas, Ilya Zhbannikov, Maros Ferencik, Borek Foldyna, Udo Hoffmann, Svati H. Shah, Geoffrey S. Ginsburg, Michael T. Lu, Deepak Voora

Research output: Contribution to journal › Letter › peer-review

1 Scopus citations

Abstract

A polygenic risk score (PGS) is associated with obstructive coronary artery disease (CAD) independent of traditional risk factors. Coronary computed tomography angiography (CTA) can characterize coronary plaques, including features of highrisk CAD. However, it is unknown if a PGS is associated with obstructive CAD and high-risk CAD phenotypes in patients with symptoms suggestive of CAD.

Original language	English (US)
Pages (from-to)	12-15
Number of pages	4
Journal	American heart journal
Volume	252
DOIs	https://doi.org/10.1016/j.ahj.2022.05.012
State	Published - Oct 2022
Externally published	Yes

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.ahj.2022.05.012

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Newman, J. D., Douglas, P. S., Zhbannikov, I., Ferencik, M., Foldyna, B., Hoffmann, U., Shah, S. H., Ginsburg, G. S., Lu, M. T., & Voora, D. (2022). Associations of a polygenic risk score with coronary artery disease phenotypes in the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) trial. American heart journal, 252, 12-15. https://doi.org/10.1016/j.ahj.2022.05.012

Newman, JD, Douglas, PS, Zhbannikov, I, Ferencik, M, Foldyna, B, Hoffmann, U, Shah, SH, Ginsburg, GS, Lu, MT & Voora, D 2022, 'Associations of a polygenic risk score with coronary artery disease phenotypes in the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) trial', American heart journal, vol. 252, pp. 12-15. https://doi.org/10.1016/j.ahj.2022.05.012

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abstract = "A polygenic risk score (PGS) is associated with obstructive coronary artery disease (CAD) independent of traditional risk factors. Coronary computed tomography angiography (CTA) can characterize coronary plaques, including features of highrisk CAD. However, it is unknown if a PGS is associated with obstructive CAD and high-risk CAD phenotypes in patients with symptoms suggestive of CAD.",

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AU - Newman, Jonathan D.

AU - Douglas, Pamela S.

AU - Zhbannikov, Ilya

AU - Ferencik, Maros

AU - Foldyna, Borek

AU - Hoffmann, Udo

AU - Shah, Svati H.

AU - Ginsburg, Geoffrey S.

AU - Lu, Michael T.

AU - Voora, Deepak

PY - 2022/10

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N2 - A polygenic risk score (PGS) is associated with obstructive coronary artery disease (CAD) independent of traditional risk factors. Coronary computed tomography angiography (CTA) can characterize coronary plaques, including features of highrisk CAD. However, it is unknown if a PGS is associated with obstructive CAD and high-risk CAD phenotypes in patients with symptoms suggestive of CAD.

AB - A polygenic risk score (PGS) is associated with obstructive coronary artery disease (CAD) independent of traditional risk factors. Coronary computed tomography angiography (CTA) can characterize coronary plaques, including features of highrisk CAD. However, it is unknown if a PGS is associated with obstructive CAD and high-risk CAD phenotypes in patients with symptoms suggestive of CAD.

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ER -

Associations of a polygenic risk score with coronary artery disease phenotypes in the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) trial

Abstract

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