Associations between male anogenital human papillomavirus infection and circumcision by anatomic site sampled and lifetime number of female sex partners

Carrie Nielson, Melody K. Schiaffino, Eileen F. Dunne, Jason L. Salemi, Anna R. Giuliano

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Background. Male circumcision may lower men's risk of human papillomavirus (HPV) infection and reduce transmission to sex partners. Reported associations between circumcision and HPV infection in men have been inconsistent. Methods. Four hundred sixty-three men in 2 US cities were tested at 6 anogenital sites and in semen for 37 types of HPV. Men were eligible if they reported sex with a woman within the past year, no history of genital warts or penile or anal cancer, and no current diagnosis of a sexually transmitted infection. Participants completed a selfadministered questionnaire. Circumcision status was assessed by the study clinician. Logistic regression was used to examine associations between circumcision and HPV detection at each site and in semen, with adjustment for potential confounders. Results. Seventy-four men (16.0%) were uncircumcised. Adjusted odds ratios (AORs) for any HPV genotype and circumcision were 0.53 (95% confidence interval [CI], 0.28-0.99) for any anatomic site/specimen, 0.17 (95% CI, 0.05-0.56) for the urethra, 0.44 (95% CI, 0.23-0.82) for the glans/corona, and 0.53 (95% CI, 0.28-0.99) for the penile shaft. AORs were

Original languageEnglish (US)
Pages (from-to)7-13
Number of pages7
JournalJournal of Infectious Diseases
Volume199
Issue number1
DOIs
StatePublished - Jan 1 2009

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Papillomavirus Infections
Confidence Intervals
Semen
Odds Ratio
Penile Neoplasms
Anus Neoplasms
Condylomata Acuminata
Male Circumcision
Infectious Disease Transmission
Urethra
Sexually Transmitted Diseases
Logistic Models
Genotype

ASJC Scopus subject areas

  • Infectious Diseases
  • Immunology and Allergy

Cite this

Associations between male anogenital human papillomavirus infection and circumcision by anatomic site sampled and lifetime number of female sex partners. / Nielson, Carrie; Schiaffino, Melody K.; Dunne, Eileen F.; Salemi, Jason L.; Giuliano, Anna R.

In: Journal of Infectious Diseases, Vol. 199, No. 1, 01.01.2009, p. 7-13.

Research output: Contribution to journalArticle

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abstract = "Background. Male circumcision may lower men's risk of human papillomavirus (HPV) infection and reduce transmission to sex partners. Reported associations between circumcision and HPV infection in men have been inconsistent. Methods. Four hundred sixty-three men in 2 US cities were tested at 6 anogenital sites and in semen for 37 types of HPV. Men were eligible if they reported sex with a woman within the past year, no history of genital warts or penile or anal cancer, and no current diagnosis of a sexually transmitted infection. Participants completed a selfadministered questionnaire. Circumcision status was assessed by the study clinician. Logistic regression was used to examine associations between circumcision and HPV detection at each site and in semen, with adjustment for potential confounders. Results. Seventy-four men (16.0{\%}) were uncircumcised. Adjusted odds ratios (AORs) for any HPV genotype and circumcision were 0.53 (95{\%} confidence interval [CI], 0.28-0.99) for any anatomic site/specimen, 0.17 (95{\%} CI, 0.05-0.56) for the urethra, 0.44 (95{\%} CI, 0.23-0.82) for the glans/corona, and 0.53 (95{\%} CI, 0.28-0.99) for the penile shaft. AORs were",
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