Association of SWAP-70 with the B cell antigen receptor complex

L. Masat, J. Caldwell, R. Armstrong, H. Khoshnevisan, R. Jessberger, B. Herndier, M. Wabl, D. Ferrick

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

SWAP-70 is a component of an enzyme complex that recombines Ig switch regions in vitro. We report here the cloning of the human cDNA and its B lymphocyte-specific expression. Although its sequence contains three nuclear localization signals, in small resting B cells, SWAP-70 is mainly found in the cytoplasm. On stimulation, SWAP-70 translocates to the nucleus. In activated, class-switching B cell cultures, it is associated with membrane IgG, but not IgM. The membrane Ig association requires a functional pleckstrin homology domain and is controlled by the C terminus. We suggest that SWAP-70 is involved not only in nuclear events but also in signaling in B cell activation.

Original languageEnglish (US)
Pages (from-to)2180-2184
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume97
Issue number5
DOIs
StatePublished - Feb 29 2000
Externally publishedYes

ASJC Scopus subject areas

  • General

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