TY - JOUR
T1 - Association of SWAP-70 with the B cell antigen receptor complex
AU - Masat, L.
AU - Caldwell, J.
AU - Armstrong, R.
AU - Khoshnevisan, H.
AU - Jessberger, R.
AU - Herndier, B.
AU - Wabl, M.
AU - Ferrick, D.
PY - 2000/2/29
Y1 - 2000/2/29
N2 - SWAP-70 is a component of an enzyme complex that recombines Ig switch regions in vitro. We report here the cloning of the human cDNA and its B lymphocyte-specific expression. Although its sequence contains three nuclear localization signals, in small resting B cells, SWAP-70 is mainly found in the cytoplasm. On stimulation, SWAP-70 translocates to the nucleus. In activated, class-switching B cell cultures, it is associated with membrane IgG, but not IgM. The membrane Ig association requires a functional pleckstrin homology domain and is controlled by the C terminus. We suggest that SWAP-70 is involved not only in nuclear events but also in signaling in B cell activation.
AB - SWAP-70 is a component of an enzyme complex that recombines Ig switch regions in vitro. We report here the cloning of the human cDNA and its B lymphocyte-specific expression. Although its sequence contains three nuclear localization signals, in small resting B cells, SWAP-70 is mainly found in the cytoplasm. On stimulation, SWAP-70 translocates to the nucleus. In activated, class-switching B cell cultures, it is associated with membrane IgG, but not IgM. The membrane Ig association requires a functional pleckstrin homology domain and is controlled by the C terminus. We suggest that SWAP-70 is involved not only in nuclear events but also in signaling in B cell activation.
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U2 - 10.1073/pnas.040374497
DO - 10.1073/pnas.040374497
M3 - Article
C2 - 10681448
AN - SCOPUS:0034008135
SN - 0027-8424
VL - 97
SP - 2180
EP - 2184
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 5
ER -