Association of stressful life events with incident falls and fractures in older men: The osteoporotic fractures in men (MrOS) Study

Howard A. Fink, Michael A. Kuskowski, Lynn Marshall

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: small, retrospective studies suggest that major life events and/or sudden emotional stress may increase fall and fracture risk. The current study examines these associations prospectively. Methods: a total of 5,152 men aged ≥65 years in the Osteoporotic Fractures in Men study self-reported data on stressful life events for 1 year prior to study Visit 2. Incident falls and fractures were ascertained for 1 year after Visit 2. Fractures were centrally confirmed. Results: a total of 2,932 (56.9%) men reported ≥1 type of stressful life event. In men with complete stressful life event, fall and covariate data (n = 3,949), any stressful life event was associated with a 33% increased risk of incident fall [relative risk (RR) 1.33, 95% confidence interval (CI) 1.19-1.49] and 68% increased risk of multiple falls (RR = 1.68, 95% CI = 1.40-2.01) in the year following Visit 2 after adjustment for age, education, Parkinson's disease, diabetes, stroke, instrumental activities of daily living (IADL) impairment, chair stand time, walk speed, multiple past falls, depressive symptoms and antidepressant use. Risk increased with the number of types of stressful life events. Though any stressful life event was associated with a 58% increased age-adjusted risk for incident fracture, this association was attenuated and no longer statistically significant after additional adjustment for total hip bone mineral density, fracture after age 50, Parkinson's disease, stroke and IADL impairment. Conclusions: in this cohort of older men, stressful life events significantly increased risk of incident falls independent of other explanatory variables, but did not independently increase incident fracture risk.

Original languageEnglish (US)
Article numberaft117
Pages (from-to)103-108
Number of pages6
JournalAge and Ageing
Volume43
Issue number1
DOIs
StatePublished - Jan 2014

Fingerprint

Osteoporotic Fractures
Activities of Daily Living
Parkinson Disease
Stroke
Pelvic Bones
Confidence Intervals
Psychological Stress
Bone Density
Antidepressive Agents
Retrospective Studies
Depression
Education

Keywords

  • Accidental falls
  • Aged
  • Fractures
  • Life change events
  • Male
  • Men
  • Older people
  • Prospective studies
  • Psychological stress

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

Cite this

Association of stressful life events with incident falls and fractures in older men : The osteoporotic fractures in men (MrOS) Study. / Fink, Howard A.; Kuskowski, Michael A.; Marshall, Lynn.

In: Age and Ageing, Vol. 43, No. 1, aft117, 01.2014, p. 103-108.

Research output: Contribution to journalArticle

@article{c1143ff3d20541f5a07597d5a0c2c5c4,
title = "Association of stressful life events with incident falls and fractures in older men: The osteoporotic fractures in men (MrOS) Study",
abstract = "Background: small, retrospective studies suggest that major life events and/or sudden emotional stress may increase fall and fracture risk. The current study examines these associations prospectively. Methods: a total of 5,152 men aged ≥65 years in the Osteoporotic Fractures in Men study self-reported data on stressful life events for 1 year prior to study Visit 2. Incident falls and fractures were ascertained for 1 year after Visit 2. Fractures were centrally confirmed. Results: a total of 2,932 (56.9{\%}) men reported ≥1 type of stressful life event. In men with complete stressful life event, fall and covariate data (n = 3,949), any stressful life event was associated with a 33{\%} increased risk of incident fall [relative risk (RR) 1.33, 95{\%} confidence interval (CI) 1.19-1.49] and 68{\%} increased risk of multiple falls (RR = 1.68, 95{\%} CI = 1.40-2.01) in the year following Visit 2 after adjustment for age, education, Parkinson's disease, diabetes, stroke, instrumental activities of daily living (IADL) impairment, chair stand time, walk speed, multiple past falls, depressive symptoms and antidepressant use. Risk increased with the number of types of stressful life events. Though any stressful life event was associated with a 58{\%} increased age-adjusted risk for incident fracture, this association was attenuated and no longer statistically significant after additional adjustment for total hip bone mineral density, fracture after age 50, Parkinson's disease, stroke and IADL impairment. Conclusions: in this cohort of older men, stressful life events significantly increased risk of incident falls independent of other explanatory variables, but did not independently increase incident fracture risk.",
keywords = "Accidental falls, Aged, Fractures, Life change events, Male, Men, Older people, Prospective studies, Psychological stress",
author = "Fink, {Howard A.} and Kuskowski, {Michael A.} and Lynn Marshall",
year = "2014",
month = "1",
doi = "10.1093/ageing/aft117",
language = "English (US)",
volume = "43",
pages = "103--108",
journal = "Age and Ageing",
issn = "0002-0729",
publisher = "Oxford University Press",
number = "1",

}

TY - JOUR

T1 - Association of stressful life events with incident falls and fractures in older men

T2 - The osteoporotic fractures in men (MrOS) Study

AU - Fink, Howard A.

AU - Kuskowski, Michael A.

AU - Marshall, Lynn

PY - 2014/1

Y1 - 2014/1

N2 - Background: small, retrospective studies suggest that major life events and/or sudden emotional stress may increase fall and fracture risk. The current study examines these associations prospectively. Methods: a total of 5,152 men aged ≥65 years in the Osteoporotic Fractures in Men study self-reported data on stressful life events for 1 year prior to study Visit 2. Incident falls and fractures were ascertained for 1 year after Visit 2. Fractures were centrally confirmed. Results: a total of 2,932 (56.9%) men reported ≥1 type of stressful life event. In men with complete stressful life event, fall and covariate data (n = 3,949), any stressful life event was associated with a 33% increased risk of incident fall [relative risk (RR) 1.33, 95% confidence interval (CI) 1.19-1.49] and 68% increased risk of multiple falls (RR = 1.68, 95% CI = 1.40-2.01) in the year following Visit 2 after adjustment for age, education, Parkinson's disease, diabetes, stroke, instrumental activities of daily living (IADL) impairment, chair stand time, walk speed, multiple past falls, depressive symptoms and antidepressant use. Risk increased with the number of types of stressful life events. Though any stressful life event was associated with a 58% increased age-adjusted risk for incident fracture, this association was attenuated and no longer statistically significant after additional adjustment for total hip bone mineral density, fracture after age 50, Parkinson's disease, stroke and IADL impairment. Conclusions: in this cohort of older men, stressful life events significantly increased risk of incident falls independent of other explanatory variables, but did not independently increase incident fracture risk.

AB - Background: small, retrospective studies suggest that major life events and/or sudden emotional stress may increase fall and fracture risk. The current study examines these associations prospectively. Methods: a total of 5,152 men aged ≥65 years in the Osteoporotic Fractures in Men study self-reported data on stressful life events for 1 year prior to study Visit 2. Incident falls and fractures were ascertained for 1 year after Visit 2. Fractures were centrally confirmed. Results: a total of 2,932 (56.9%) men reported ≥1 type of stressful life event. In men with complete stressful life event, fall and covariate data (n = 3,949), any stressful life event was associated with a 33% increased risk of incident fall [relative risk (RR) 1.33, 95% confidence interval (CI) 1.19-1.49] and 68% increased risk of multiple falls (RR = 1.68, 95% CI = 1.40-2.01) in the year following Visit 2 after adjustment for age, education, Parkinson's disease, diabetes, stroke, instrumental activities of daily living (IADL) impairment, chair stand time, walk speed, multiple past falls, depressive symptoms and antidepressant use. Risk increased with the number of types of stressful life events. Though any stressful life event was associated with a 58% increased age-adjusted risk for incident fracture, this association was attenuated and no longer statistically significant after additional adjustment for total hip bone mineral density, fracture after age 50, Parkinson's disease, stroke and IADL impairment. Conclusions: in this cohort of older men, stressful life events significantly increased risk of incident falls independent of other explanatory variables, but did not independently increase incident fracture risk.

KW - Accidental falls

KW - Aged

KW - Fractures

KW - Life change events

KW - Male

KW - Men

KW - Older people

KW - Prospective studies

KW - Psychological stress

UR - http://www.scopus.com/inward/record.url?scp=84890370860&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84890370860&partnerID=8YFLogxK

U2 - 10.1093/ageing/aft117

DO - 10.1093/ageing/aft117

M3 - Article

C2 - 24002237

AN - SCOPUS:84890370860

VL - 43

SP - 103

EP - 108

JO - Age and Ageing

JF - Age and Ageing

SN - 0002-0729

IS - 1

M1 - aft117

ER -