Association of SNCA with Parkinson: Replication in the Harvard NeuroDiscovery Center Biomarker Study

Hongliu Ding, Alison K. Sarokhan, Sarah S. Roderick, Rachit Bakshi, Nancy E. Maher, Paymon Ashourian, Caroline G. Kan, Sunny Chang, Andrea Santarlasci, Kyleen E. Swords, Bernard M. Ravina, Michael T. Hayes, U. Shivraj Sohur, Anne Marie Wills, Alice W. Flaherty, Vivek Unni, Albert Y. Hung, Dennis J. Selkoe, Michael A. Schwarzschild, Michael G. SchlossmacherLewis R. Sudarsky, John H. Growdon, Adrian J. Ivinson, Bradley T. Hyman, Clemens R. Scherzer

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background:: Mutations in the α-synuclein gene (SNCA) cause autosomal dominant forms of Parkinson's disease, but the substantial risk conferred by this locus to the common sporadic disease has only recently emerged from genome-wide association studies. Methods:: We genotyped a prioritized noncoding variant in SNCA intron 4 in 344 patients with Parkinson's disease and 275 controls from the longitudinal Harvard NeuroDiscovery Center Biomarker Study. Results:: The common minor allele of rs2736990 was associated with elevated disease susceptibility (odds ratio, 1.40; P =.0032). Conclusions:: This result increases confidence in the notion that in many clinically well-characterized patients, genetic variation in SNCA contributes to "sporadic" disease.

Original languageEnglish (US)
Pages (from-to)2283-2286
Number of pages4
JournalMovement Disorders
Volume26
Issue number12
DOIs
StatePublished - Oct 2011
Externally publishedYes

Fingerprint

Synucleins
Biomarkers
Genome-Wide Association Study
Disease Susceptibility
Introns
Parkinson Disease
Alleles
Odds Ratio
Mutation
Genes
Parkinson Disease, Familial, Type 1

Keywords

  • α-synuclein
  • Biomarker
  • GATA transcription factors
  • Genome-wide association study
  • Parkinson's disease

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Ding, H., Sarokhan, A. K., Roderick, S. S., Bakshi, R., Maher, N. E., Ashourian, P., ... Scherzer, C. R. (2011). Association of SNCA with Parkinson: Replication in the Harvard NeuroDiscovery Center Biomarker Study. Movement Disorders, 26(12), 2283-2286. https://doi.org/10.1002/mds.23934

Association of SNCA with Parkinson : Replication in the Harvard NeuroDiscovery Center Biomarker Study. / Ding, Hongliu; Sarokhan, Alison K.; Roderick, Sarah S.; Bakshi, Rachit; Maher, Nancy E.; Ashourian, Paymon; Kan, Caroline G.; Chang, Sunny; Santarlasci, Andrea; Swords, Kyleen E.; Ravina, Bernard M.; Hayes, Michael T.; Sohur, U. Shivraj; Wills, Anne Marie; Flaherty, Alice W.; Unni, Vivek; Hung, Albert Y.; Selkoe, Dennis J.; Schwarzschild, Michael A.; Schlossmacher, Michael G.; Sudarsky, Lewis R.; Growdon, John H.; Ivinson, Adrian J.; Hyman, Bradley T.; Scherzer, Clemens R.

In: Movement Disorders, Vol. 26, No. 12, 10.2011, p. 2283-2286.

Research output: Contribution to journalArticle

Ding, H, Sarokhan, AK, Roderick, SS, Bakshi, R, Maher, NE, Ashourian, P, Kan, CG, Chang, S, Santarlasci, A, Swords, KE, Ravina, BM, Hayes, MT, Sohur, US, Wills, AM, Flaherty, AW, Unni, V, Hung, AY, Selkoe, DJ, Schwarzschild, MA, Schlossmacher, MG, Sudarsky, LR, Growdon, JH, Ivinson, AJ, Hyman, BT & Scherzer, CR 2011, 'Association of SNCA with Parkinson: Replication in the Harvard NeuroDiscovery Center Biomarker Study', Movement Disorders, vol. 26, no. 12, pp. 2283-2286. https://doi.org/10.1002/mds.23934
Ding H, Sarokhan AK, Roderick SS, Bakshi R, Maher NE, Ashourian P et al. Association of SNCA with Parkinson: Replication in the Harvard NeuroDiscovery Center Biomarker Study. Movement Disorders. 2011 Oct;26(12):2283-2286. https://doi.org/10.1002/mds.23934
Ding, Hongliu ; Sarokhan, Alison K. ; Roderick, Sarah S. ; Bakshi, Rachit ; Maher, Nancy E. ; Ashourian, Paymon ; Kan, Caroline G. ; Chang, Sunny ; Santarlasci, Andrea ; Swords, Kyleen E. ; Ravina, Bernard M. ; Hayes, Michael T. ; Sohur, U. Shivraj ; Wills, Anne Marie ; Flaherty, Alice W. ; Unni, Vivek ; Hung, Albert Y. ; Selkoe, Dennis J. ; Schwarzschild, Michael A. ; Schlossmacher, Michael G. ; Sudarsky, Lewis R. ; Growdon, John H. ; Ivinson, Adrian J. ; Hyman, Bradley T. ; Scherzer, Clemens R. / Association of SNCA with Parkinson : Replication in the Harvard NeuroDiscovery Center Biomarker Study. In: Movement Disorders. 2011 ; Vol. 26, No. 12. pp. 2283-2286.
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