Association of SNCA with Parkinson: Replication in the Harvard NeuroDiscovery Center Biomarker Study

Hongliu Ding; Alison K. Sarokhan; Sarah S. Roderick; Rachit Bakshi; Nancy E. Maher; Paymon Ashourian; Caroline G. Kan; Sunny Chang; Andrea Santarlasci; Kyleen E. Swords; Bernard M. Ravina; Michael T. Hayes; U. Shivraj Sohur; Anne Marie Wills; Alice W. Flaherty; Vivek K. Unni; Albert Y. Hung; Dennis J. Selkoe; Michael A. Schwarzschild; Michael G. Schlossmacher; Lewis R. Sudarsky; John H. Growdon; Adrian J. Ivinson; Bradley T. Hyman; Clemens R. Scherzer

doi:10.1002/mds.23934

Association of SNCA with Parkinson: Replication in the Harvard NeuroDiscovery Center Biomarker Study

Hongliu Ding, Alison K. Sarokhan, Sarah S. Roderick, Rachit Bakshi, Nancy E. Maher, Paymon Ashourian, Caroline G. Kan, Sunny Chang, Andrea Santarlasci, Kyleen E. Swords, Bernard M. Ravina, Michael T. Hayes, U. Shivraj Sohur, Anne Marie Wills, Alice W. Flaherty, Vivek K. Unni, Albert Y. Hung, Dennis J. Selkoe, Michael A. Schwarzschild, Michael G. SchlossmacherLewis R. Sudarsky, John H. Growdon, Adrian J. Ivinson, Bradley T. Hyman, Clemens R. Scherzer

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Background:: Mutations in the α-synuclein gene (SNCA) cause autosomal dominant forms of Parkinson's disease, but the substantial risk conferred by this locus to the common sporadic disease has only recently emerged from genome-wide association studies. Methods:: We genotyped a prioritized noncoding variant in SNCA intron 4 in 344 patients with Parkinson's disease and 275 controls from the longitudinal Harvard NeuroDiscovery Center Biomarker Study. Results:: The common minor allele of rs2736990 was associated with elevated disease susceptibility (odds ratio, 1.40; P =.0032). Conclusions:: This result increases confidence in the notion that in many clinically well-characterized patients, genetic variation in SNCA contributes to "sporadic" disease.

Original language	English (US)
Pages (from-to)	2283-2286
Number of pages	4
Journal	Movement Disorders
Volume	26
Issue number	12
DOIs	https://doi.org/10.1002/mds.23934
State	Published - Oct 2011
Externally published	Yes

Keywords

Biomarker
GATA transcription factors
Genome-wide association study
Parkinson's disease
α-synuclein

ASJC Scopus subject areas

Neurology
Clinical Neurology

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Ding, H., Sarokhan, A. K., Roderick, S. S., Bakshi, R., Maher, N. E., Ashourian, P., Kan, C. G., Chang, S., Santarlasci, A., Swords, K. E., Ravina, B. M., Hayes, M. T., Sohur, U. S., Wills, A. M., Flaherty, A. W., Unni, V. K., Hung, A. Y., Selkoe, D. J., Schwarzschild, M. A., ... Scherzer, C. R. (2011). Association of SNCA with Parkinson: Replication in the Harvard NeuroDiscovery Center Biomarker Study. Movement Disorders, 26(12), 2283-2286. https://doi.org/10.1002/mds.23934

Ding, H, Sarokhan, AK, Roderick, SS, Bakshi, R, Maher, NE, Ashourian, P, Kan, CG, Chang, S, Santarlasci, A, Swords, KE, Ravina, BM, Hayes, MT, Sohur, US, Wills, AM, Flaherty, AW, Unni, VK, Hung, AY, Selkoe, DJ, Schwarzschild, MA, Schlossmacher, MG, Sudarsky, LR, Growdon, JH, Ivinson, AJ, Hyman, BT & Scherzer, CR 2011, 'Association of SNCA with Parkinson: Replication in the Harvard NeuroDiscovery Center Biomarker Study', Movement Disorders, vol. 26, no. 12, pp. 2283-2286. https://doi.org/10.1002/mds.23934

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title = "Association of SNCA with Parkinson: Replication in the Harvard NeuroDiscovery Center Biomarker Study",

abstract = "Background:: Mutations in the α-synuclein gene (SNCA) cause autosomal dominant forms of Parkinson's disease, but the substantial risk conferred by this locus to the common sporadic disease has only recently emerged from genome-wide association studies. Methods:: We genotyped a prioritized noncoding variant in SNCA intron 4 in 344 patients with Parkinson's disease and 275 controls from the longitudinal Harvard NeuroDiscovery Center Biomarker Study. Results:: The common minor allele of rs2736990 was associated with elevated disease susceptibility (odds ratio, 1.40; P =.0032). Conclusions:: This result increases confidence in the notion that in many clinically well-characterized patients, genetic variation in SNCA contributes to {"}sporadic{"} disease.",

keywords = "Biomarker, GATA transcription factors, Genome-wide association study, Parkinson's disease, α-synuclein",

author = "Hongliu Ding and Sarokhan, {Alison K.} and Roderick, {Sarah S.} and Rachit Bakshi and Maher, {Nancy E.} and Paymon Ashourian and Kan, {Caroline G.} and Sunny Chang and Andrea Santarlasci and Swords, {Kyleen E.} and Ravina, {Bernard M.} and Hayes, {Michael T.} and Sohur, {U. Shivraj} and Wills, {Anne Marie} and Flaherty, {Alice W.} and Unni, {Vivek K.} and Hung, {Albert Y.} and Selkoe, {Dennis J.} and Schwarzschild, {Michael A.} and Schlossmacher, {Michael G.} and Sudarsky, {Lewis R.} and Growdon, {John H.} and Ivinson, {Adrian J.} and Hyman, {Bradley T.} and Scherzer, {Clemens R.}",

year = "2011",

month = oct,

doi = "10.1002/mds.23934",

language = "English (US)",

volume = "26",

pages = "2283--2286",

journal = "Movement Disorders",

issn = "0885-3185",

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T1 - Association of SNCA with Parkinson

T2 - Replication in the Harvard NeuroDiscovery Center Biomarker Study

AU - Ding, Hongliu

AU - Sarokhan, Alison K.

AU - Roderick, Sarah S.

AU - Bakshi, Rachit

AU - Maher, Nancy E.

AU - Ashourian, Paymon

AU - Kan, Caroline G.

AU - Chang, Sunny

AU - Santarlasci, Andrea

AU - Swords, Kyleen E.

AU - Ravina, Bernard M.

AU - Hayes, Michael T.

AU - Sohur, U. Shivraj

AU - Wills, Anne Marie

AU - Flaherty, Alice W.

AU - Unni, Vivek K.

AU - Hung, Albert Y.

AU - Selkoe, Dennis J.

AU - Schwarzschild, Michael A.

AU - Schlossmacher, Michael G.

AU - Sudarsky, Lewis R.

AU - Growdon, John H.

AU - Ivinson, Adrian J.

AU - Hyman, Bradley T.

AU - Scherzer, Clemens R.

PY - 2011/10

Y1 - 2011/10

N2 - Background:: Mutations in the α-synuclein gene (SNCA) cause autosomal dominant forms of Parkinson's disease, but the substantial risk conferred by this locus to the common sporadic disease has only recently emerged from genome-wide association studies. Methods:: We genotyped a prioritized noncoding variant in SNCA intron 4 in 344 patients with Parkinson's disease and 275 controls from the longitudinal Harvard NeuroDiscovery Center Biomarker Study. Results:: The common minor allele of rs2736990 was associated with elevated disease susceptibility (odds ratio, 1.40; P =.0032). Conclusions:: This result increases confidence in the notion that in many clinically well-characterized patients, genetic variation in SNCA contributes to "sporadic" disease.

AB - Background:: Mutations in the α-synuclein gene (SNCA) cause autosomal dominant forms of Parkinson's disease, but the substantial risk conferred by this locus to the common sporadic disease has only recently emerged from genome-wide association studies. Methods:: We genotyped a prioritized noncoding variant in SNCA intron 4 in 344 patients with Parkinson's disease and 275 controls from the longitudinal Harvard NeuroDiscovery Center Biomarker Study. Results:: The common minor allele of rs2736990 was associated with elevated disease susceptibility (odds ratio, 1.40; P =.0032). Conclusions:: This result increases confidence in the notion that in many clinically well-characterized patients, genetic variation in SNCA contributes to "sporadic" disease.

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Association of SNCA with Parkinson: Replication in the Harvard NeuroDiscovery Center Biomarker Study

Abstract

Keywords

ASJC Scopus subject areas

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