Association of Serum Selenium with Selected Cardiovascular Risk Factors

A. Menditto, F. Chiodo, S. Giampaoli, A. Menotti, G. Ricci, G. C. Urbinati, F. Angelico, M. Arca, A. Bucci, A. M. Buongiorno, D. Consalvi, R. Conti, G. Dangelo, A. Defilippis, M. Delben, E. Delmonaco, S. Fazio, A. Montali, F. Pannozzo, A. PontecorviP. Ricci, L. Sibilia, G. L. Sotis, C. Stefanutti, R. Volpe, S. Barzotti, M. Capelli, R. Capocaccia, G. Dicarlo, F. Dima, C. Lonoce, P. Lombari, M. Pasquali, A. Santaquilani, A. Verdecchia, G. Morisi

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1 Scopus citations


The association of serum selenium (S-Se) with selected cardiovascular risk factors has been studied in 3404 (1520 men, 1884 women) of 4699 subjects aged 20-73 years, who underwent a comprehensive examination between April 1986 and December 1987 within the framework of the Di.S.Co. Research Project of the National Research Council. Mean S-Se concentrations were 1.163 (SD 0.170) μmol/liter, 1.156 (0.163) μmol/liter, and 1.171 (0.179) μmol/liter in the total group, and female and male subjects, respectively. The difference by sex was statistically significant (F = 6.97, P = 0.0083). In male subjects S-Se levels were inversely associated to age (simple correlation coefficient, r = -0.2135, P < 0.001), alcohol consumption (Alcohol, r = -0.0688, P < 0.01), smoking habit (Smoke, r = -0.0663, P < 0.01), body mass index (BMI, r = -0.0596, P < 0.02), and lognormal transformation of triglycerides (Ln-Trig, r = -0.0767, P < 0.005). In multiple regression analysis Age, Smoke, Ln-Trig, and Alcohol remained significantly and inversely related to S-Se; a significant direct association of S-Se to high-density lipoprotein cholesterol (HDL) and non-HDL cholesterol (non-HDL) was also pointed out. In female subjects, S-Se was directly related to HDL (r = 0.1436, P < 0.001) and non-HDL (r = 0.0967, P < 0.001). In multiple regression analysis S-Se was directly related to both HDL and non-HDL and an inverse significant association of S-Se to Age and Alcohol was evidenced. In multivariate regression models analyzing systolic (SEP), diastolic (DBP), and mean blood pressure (MBP) as dependent variables, S-Se was a weak significant positive predictor in male but not in female subjects.

Original languageEnglish (US)
Pages (from-to)170-180
Number of pages11
JournalMicrochemical Journal
Issue number1-2
StatePublished - Feb 1995
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy


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