TY - JOUR
T1 - Association of Serum Selenium with Selected Cardiovascular Risk Factors
AU - Menditto, A.
AU - Chiodo, F.
AU - Giampaoli, S.
AU - Menotti, A.
AU - Ricci, G.
AU - Urbinati, G. C.
AU - Angelico, F.
AU - Arca, M.
AU - Bucci, A.
AU - Buongiorno, A. M.
AU - Consalvi, D.
AU - Conti, R.
AU - Dangelo, G.
AU - Defilippis, A.
AU - Delben, M.
AU - Delmonaco, E.
AU - Fazio, S.
AU - Montali, A.
AU - Pannozzo, F.
AU - Pontecorvi, A.
AU - Ricci, P.
AU - Sibilia, L.
AU - Sotis, G. L.
AU - Stefanutti, C.
AU - Volpe, R.
AU - Barzotti, S.
AU - Capelli, M.
AU - Capocaccia, R.
AU - Dicarlo, G.
AU - Dima, F.
AU - Lonoce, C.
AU - Lombari, P.
AU - Pasquali, M.
AU - Santaquilani, A.
AU - Verdecchia, A.
AU - Morisi, G.
PY - 1995/2
Y1 - 1995/2
N2 - The association of serum selenium (S-Se) with selected cardiovascular risk factors has been studied in 3404 (1520 men, 1884 women) of 4699 subjects aged 20-73 years, who underwent a comprehensive examination between April 1986 and December 1987 within the framework of the Di.S.Co. Research Project of the National Research Council. Mean S-Se concentrations were 1.163 (SD 0.170) μmol/liter, 1.156 (0.163) μmol/liter, and 1.171 (0.179) μmol/liter in the total group, and female and male subjects, respectively. The difference by sex was statistically significant (F = 6.97, P = 0.0083). In male subjects S-Se levels were inversely associated to age (simple correlation coefficient, r = -0.2135, P < 0.001), alcohol consumption (Alcohol, r = -0.0688, P < 0.01), smoking habit (Smoke, r = -0.0663, P < 0.01), body mass index (BMI, r = -0.0596, P < 0.02), and lognormal transformation of triglycerides (Ln-Trig, r = -0.0767, P < 0.005). In multiple regression analysis Age, Smoke, Ln-Trig, and Alcohol remained significantly and inversely related to S-Se; a significant direct association of S-Se to high-density lipoprotein cholesterol (HDL) and non-HDL cholesterol (non-HDL) was also pointed out. In female subjects, S-Se was directly related to HDL (r = 0.1436, P < 0.001) and non-HDL (r = 0.0967, P < 0.001). In multiple regression analysis S-Se was directly related to both HDL and non-HDL and an inverse significant association of S-Se to Age and Alcohol was evidenced. In multivariate regression models analyzing systolic (SEP), diastolic (DBP), and mean blood pressure (MBP) as dependent variables, S-Se was a weak significant positive predictor in male but not in female subjects.
AB - The association of serum selenium (S-Se) with selected cardiovascular risk factors has been studied in 3404 (1520 men, 1884 women) of 4699 subjects aged 20-73 years, who underwent a comprehensive examination between April 1986 and December 1987 within the framework of the Di.S.Co. Research Project of the National Research Council. Mean S-Se concentrations were 1.163 (SD 0.170) μmol/liter, 1.156 (0.163) μmol/liter, and 1.171 (0.179) μmol/liter in the total group, and female and male subjects, respectively. The difference by sex was statistically significant (F = 6.97, P = 0.0083). In male subjects S-Se levels were inversely associated to age (simple correlation coefficient, r = -0.2135, P < 0.001), alcohol consumption (Alcohol, r = -0.0688, P < 0.01), smoking habit (Smoke, r = -0.0663, P < 0.01), body mass index (BMI, r = -0.0596, P < 0.02), and lognormal transformation of triglycerides (Ln-Trig, r = -0.0767, P < 0.005). In multiple regression analysis Age, Smoke, Ln-Trig, and Alcohol remained significantly and inversely related to S-Se; a significant direct association of S-Se to high-density lipoprotein cholesterol (HDL) and non-HDL cholesterol (non-HDL) was also pointed out. In female subjects, S-Se was directly related to HDL (r = 0.1436, P < 0.001) and non-HDL (r = 0.0967, P < 0.001). In multiple regression analysis S-Se was directly related to both HDL and non-HDL and an inverse significant association of S-Se to Age and Alcohol was evidenced. In multivariate regression models analyzing systolic (SEP), diastolic (DBP), and mean blood pressure (MBP) as dependent variables, S-Se was a weak significant positive predictor in male but not in female subjects.
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U2 - 10.1006/mchj.1995.1022
DO - 10.1006/mchj.1995.1022
M3 - Article
AN - SCOPUS:33847590045
SN - 0026-265X
VL - 51
SP - 170
EP - 180
JO - Microchemical Journal
JF - Microchemical Journal
IS - 1-2
ER -