Association of Serum Selenium with Selected Cardiovascular Risk Factors

A. Menditto, F. Chiodo, S. Giampaoli, A. Menotti, G. Ricci, G. C. Urbinati, F. Angelico, M. Arca, A. Bucci, A. M. Buongiorno, D. Consalvi, R. Conti, G. Dangelo, A. Defilippis, M. Delben, E. Delmonaco, Sergio Fazio, A. Montali, F. Pannozzo, A. PontecorviP. Ricci, L. Sibilia, G. L. Sotis, C. Stefanutti, R. Volpe, S. Barzotti, M. Capelli, R. Capocaccia, G. Dicarlo, F. Dima, C. Lonoce, P. Lombari, M. Pasquali, A. Santaquilani, A. Verdecchia, G. Morisi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The association of serum selenium (S-Se) with selected cardiovascular risk factors has been studied in 3404 (1520 men, 1884 women) of 4699 subjects aged 20-73 years, who underwent a comprehensive examination between April 1986 and December 1987 within the framework of the Di.S.Co. Research Project of the National Research Council. Mean S-Se concentrations were 1.163 (SD 0.170) μmol/liter, 1.156 (0.163) μmol/liter, and 1.171 (0.179) μmol/liter in the total group, and female and male subjects, respectively. The difference by sex was statistically significant (F = 6.97, P = 0.0083). In male subjects S-Se levels were inversely associated to age (simple correlation coefficient, r = -0.2135, P <0.001), alcohol consumption (Alcohol, r = -0.0688, P <0.01), smoking habit (Smoke, r = -0.0663, P <0.01), body mass index (BMI, r = -0.0596, P <0.02), and lognormal transformation of triglycerides (Ln-Trig, r = -0.0767, P <0.005). In multiple regression analysis Age, Smoke, Ln-Trig, and Alcohol remained significantly and inversely related to S-Se; a significant direct association of S-Se to high-density lipoprotein cholesterol (HDL) and non-HDL cholesterol (non-HDL) was also pointed out. In female subjects, S-Se was directly related to HDL (r = 0.1436, P <0.001) and non-HDL (r = 0.0967, P <0.001). In multiple regression analysis S-Se was directly related to both HDL and non-HDL and an inverse significant association of S-Se to Age and Alcohol was evidenced. In multivariate regression models analyzing systolic (SEP), diastolic (DBP), and mean blood pressure (MBP) as dependent variables, S-Se was a weak significant positive predictor in male but not in female subjects.

Original languageEnglish (US)
Pages (from-to)170-180
Number of pages11
JournalMicrochemical Journal
Volume51
Issue number1-2
DOIs
StatePublished - Feb 1995
Externally publishedYes

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Selenium
Alcohols
HDL Cholesterol
Regression analysis
Smoke
Blood pressure
Triglycerides
Cholesterol
lipoprotein cholesterol

ASJC Scopus subject areas

  • Spectroscopy
  • Analytical Chemistry

Cite this

Menditto, A., Chiodo, F., Giampaoli, S., Menotti, A., Ricci, G., Urbinati, G. C., ... Morisi, G. (1995). Association of Serum Selenium with Selected Cardiovascular Risk Factors. Microchemical Journal, 51(1-2), 170-180. https://doi.org/10.1006/mchj.1995.1022

Association of Serum Selenium with Selected Cardiovascular Risk Factors. / Menditto, A.; Chiodo, F.; Giampaoli, S.; Menotti, A.; Ricci, G.; Urbinati, G. C.; Angelico, F.; Arca, M.; Bucci, A.; Buongiorno, A. M.; Consalvi, D.; Conti, R.; Dangelo, G.; Defilippis, A.; Delben, M.; Delmonaco, E.; Fazio, Sergio; Montali, A.; Pannozzo, F.; Pontecorvi, A.; Ricci, P.; Sibilia, L.; Sotis, G. L.; Stefanutti, C.; Volpe, R.; Barzotti, S.; Capelli, M.; Capocaccia, R.; Dicarlo, G.; Dima, F.; Lonoce, C.; Lombari, P.; Pasquali, M.; Santaquilani, A.; Verdecchia, A.; Morisi, G.

In: Microchemical Journal, Vol. 51, No. 1-2, 02.1995, p. 170-180.

Research output: Contribution to journalArticle

Menditto, A, Chiodo, F, Giampaoli, S, Menotti, A, Ricci, G, Urbinati, GC, Angelico, F, Arca, M, Bucci, A, Buongiorno, AM, Consalvi, D, Conti, R, Dangelo, G, Defilippis, A, Delben, M, Delmonaco, E, Fazio, S, Montali, A, Pannozzo, F, Pontecorvi, A, Ricci, P, Sibilia, L, Sotis, GL, Stefanutti, C, Volpe, R, Barzotti, S, Capelli, M, Capocaccia, R, Dicarlo, G, Dima, F, Lonoce, C, Lombari, P, Pasquali, M, Santaquilani, A, Verdecchia, A & Morisi, G 1995, 'Association of Serum Selenium with Selected Cardiovascular Risk Factors', Microchemical Journal, vol. 51, no. 1-2, pp. 170-180. https://doi.org/10.1006/mchj.1995.1022
Menditto A, Chiodo F, Giampaoli S, Menotti A, Ricci G, Urbinati GC et al. Association of Serum Selenium with Selected Cardiovascular Risk Factors. Microchemical Journal. 1995 Feb;51(1-2):170-180. https://doi.org/10.1006/mchj.1995.1022
Menditto, A. ; Chiodo, F. ; Giampaoli, S. ; Menotti, A. ; Ricci, G. ; Urbinati, G. C. ; Angelico, F. ; Arca, M. ; Bucci, A. ; Buongiorno, A. M. ; Consalvi, D. ; Conti, R. ; Dangelo, G. ; Defilippis, A. ; Delben, M. ; Delmonaco, E. ; Fazio, Sergio ; Montali, A. ; Pannozzo, F. ; Pontecorvi, A. ; Ricci, P. ; Sibilia, L. ; Sotis, G. L. ; Stefanutti, C. ; Volpe, R. ; Barzotti, S. ; Capelli, M. ; Capocaccia, R. ; Dicarlo, G. ; Dima, F. ; Lonoce, C. ; Lombari, P. ; Pasquali, M. ; Santaquilani, A. ; Verdecchia, A. ; Morisi, G. / Association of Serum Selenium with Selected Cardiovascular Risk Factors. In: Microchemical Journal. 1995 ; Vol. 51, No. 1-2. pp. 170-180.
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title = "Association of Serum Selenium with Selected Cardiovascular Risk Factors",
abstract = "The association of serum selenium (S-Se) with selected cardiovascular risk factors has been studied in 3404 (1520 men, 1884 women) of 4699 subjects aged 20-73 years, who underwent a comprehensive examination between April 1986 and December 1987 within the framework of the Di.S.Co. Research Project of the National Research Council. Mean S-Se concentrations were 1.163 (SD 0.170) μmol/liter, 1.156 (0.163) μmol/liter, and 1.171 (0.179) μmol/liter in the total group, and female and male subjects, respectively. The difference by sex was statistically significant (F = 6.97, P = 0.0083). In male subjects S-Se levels were inversely associated to age (simple correlation coefficient, r = -0.2135, P <0.001), alcohol consumption (Alcohol, r = -0.0688, P <0.01), smoking habit (Smoke, r = -0.0663, P <0.01), body mass index (BMI, r = -0.0596, P <0.02), and lognormal transformation of triglycerides (Ln-Trig, r = -0.0767, P <0.005). In multiple regression analysis Age, Smoke, Ln-Trig, and Alcohol remained significantly and inversely related to S-Se; a significant direct association of S-Se to high-density lipoprotein cholesterol (HDL) and non-HDL cholesterol (non-HDL) was also pointed out. In female subjects, S-Se was directly related to HDL (r = 0.1436, P <0.001) and non-HDL (r = 0.0967, P <0.001). In multiple regression analysis S-Se was directly related to both HDL and non-HDL and an inverse significant association of S-Se to Age and Alcohol was evidenced. In multivariate regression models analyzing systolic (SEP), diastolic (DBP), and mean blood pressure (MBP) as dependent variables, S-Se was a weak significant positive predictor in male but not in female subjects.",
author = "A. Menditto and F. Chiodo and S. Giampaoli and A. Menotti and G. Ricci and Urbinati, {G. C.} and F. Angelico and M. Arca and A. Bucci and Buongiorno, {A. M.} and D. Consalvi and R. Conti and G. Dangelo and A. Defilippis and M. Delben and E. Delmonaco and Sergio Fazio and A. Montali and F. Pannozzo and A. Pontecorvi and P. Ricci and L. Sibilia and Sotis, {G. L.} and C. Stefanutti and R. Volpe and S. Barzotti and M. Capelli and R. Capocaccia and G. Dicarlo and F. Dima and C. Lonoce and P. Lombari and M. Pasquali and A. Santaquilani and A. Verdecchia and G. Morisi",
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T1 - Association of Serum Selenium with Selected Cardiovascular Risk Factors

AU - Menditto, A.

AU - Chiodo, F.

AU - Giampaoli, S.

AU - Menotti, A.

AU - Ricci, G.

AU - Urbinati, G. C.

AU - Angelico, F.

AU - Arca, M.

AU - Bucci, A.

AU - Buongiorno, A. M.

AU - Consalvi, D.

AU - Conti, R.

AU - Dangelo, G.

AU - Defilippis, A.

AU - Delben, M.

AU - Delmonaco, E.

AU - Fazio, Sergio

AU - Montali, A.

AU - Pannozzo, F.

AU - Pontecorvi, A.

AU - Ricci, P.

AU - Sibilia, L.

AU - Sotis, G. L.

AU - Stefanutti, C.

AU - Volpe, R.

AU - Barzotti, S.

AU - Capelli, M.

AU - Capocaccia, R.

AU - Dicarlo, G.

AU - Dima, F.

AU - Lonoce, C.

AU - Lombari, P.

AU - Pasquali, M.

AU - Santaquilani, A.

AU - Verdecchia, A.

AU - Morisi, G.

PY - 1995/2

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N2 - The association of serum selenium (S-Se) with selected cardiovascular risk factors has been studied in 3404 (1520 men, 1884 women) of 4699 subjects aged 20-73 years, who underwent a comprehensive examination between April 1986 and December 1987 within the framework of the Di.S.Co. Research Project of the National Research Council. Mean S-Se concentrations were 1.163 (SD 0.170) μmol/liter, 1.156 (0.163) μmol/liter, and 1.171 (0.179) μmol/liter in the total group, and female and male subjects, respectively. The difference by sex was statistically significant (F = 6.97, P = 0.0083). In male subjects S-Se levels were inversely associated to age (simple correlation coefficient, r = -0.2135, P <0.001), alcohol consumption (Alcohol, r = -0.0688, P <0.01), smoking habit (Smoke, r = -0.0663, P <0.01), body mass index (BMI, r = -0.0596, P <0.02), and lognormal transformation of triglycerides (Ln-Trig, r = -0.0767, P <0.005). In multiple regression analysis Age, Smoke, Ln-Trig, and Alcohol remained significantly and inversely related to S-Se; a significant direct association of S-Se to high-density lipoprotein cholesterol (HDL) and non-HDL cholesterol (non-HDL) was also pointed out. In female subjects, S-Se was directly related to HDL (r = 0.1436, P <0.001) and non-HDL (r = 0.0967, P <0.001). In multiple regression analysis S-Se was directly related to both HDL and non-HDL and an inverse significant association of S-Se to Age and Alcohol was evidenced. In multivariate regression models analyzing systolic (SEP), diastolic (DBP), and mean blood pressure (MBP) as dependent variables, S-Se was a weak significant positive predictor in male but not in female subjects.

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