Association of self-reported race/ethnicity and genetic ancestry with arterial elasticity

The Multi-Ethnic Study of Atherosclerosis (MESA)

Christina L. Wassel, David R. Jacobs, Daniel A. Duprez, David A. Bluemke, Christopher Sibley, Michael H. Criqui, Carmen A. Peralta

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

African Americans have a disproportionate burden of hypertension compared with white, whereas data on Hispanics is less well-defined. Mechanisms underlying these differences are unclear, but could be in part because of ancestral background and vascular function. We studied 660 African Americans and 635 Hispanics from the Multi-Ethnic Study of Atherosclerosis (MESA) with complete data on genetic ancestry, pulse pressure (PP), and large and small arterial elasticity (LAE, SAE). LAE and SAE were obtained using the HDI PulseWave CR-2000 Research CardioVascular Profiling Instrument. Among African Americans, higher European ancestry was marginally associated with higher LAE (P =.05) and lower PP (P =.05); results for LAE were attenuated after adjustment for potential mediators (P =.30). Among Hispanics, higher Native American ancestry was associated with higher SAE (P =.0006); higher African ancestry was marginally associated with lower SAE (P =.07). Ancestry was not significantly associated with LAE or PP in Hispanics. Among African Americans, higher European ancestry may be associated with less large artery damage, as measured by LAE and PP, although these associations warrant further study. Among Hispanics, ancestry is strongly associated with SAE. Future studies should consider genetic ancestry when studying hypertension in race/ethnic minorities, particularly among Hispanics.

Original languageEnglish (US)
Pages (from-to)463-472
Number of pages10
JournalJournal of the American Society of Hypertension
Volume5
Issue number6
DOIs
StatePublished - Nov 2011
Externally publishedYes

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Elasticity
Hispanic Americans
Atherosclerosis
African Americans
Blood Pressure
Hypertension
North American Indians
Blood Vessels
Arteries
Research

Keywords

  • admixture
  • Large artery elasticity
  • pulse pressure
  • small artery elasticity

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Internal Medicine

Cite this

Association of self-reported race/ethnicity and genetic ancestry with arterial elasticity : The Multi-Ethnic Study of Atherosclerosis (MESA). / Wassel, Christina L.; Jacobs, David R.; Duprez, Daniel A.; Bluemke, David A.; Sibley, Christopher; Criqui, Michael H.; Peralta, Carmen A.

In: Journal of the American Society of Hypertension, Vol. 5, No. 6, 11.2011, p. 463-472.

Research output: Contribution to journalArticle

Wassel, Christina L. ; Jacobs, David R. ; Duprez, Daniel A. ; Bluemke, David A. ; Sibley, Christopher ; Criqui, Michael H. ; Peralta, Carmen A. / Association of self-reported race/ethnicity and genetic ancestry with arterial elasticity : The Multi-Ethnic Study of Atherosclerosis (MESA). In: Journal of the American Society of Hypertension. 2011 ; Vol. 5, No. 6. pp. 463-472.
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