Association of pericardial fat and coronary high-risk lesions as determined by cardiac CT

Christopher L. Schlett, Maros Ferencik, Matthias F. Kriegel, Fabian Bamberg, Brian B. Ghoshhajra, Subodh B. Joshi, John T. Nagurney, Caroline S. Fox, Quynh A. Truong, Udo Hoffmann

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Objective: Pericardial adipose tissue (PAT) is a pathogenic fat depot associated with coronary atherosclerosis and cardiovascular events. We hypothesized that higher PAT is associated with coronary high-risk lesions as determined by cardiac CT. Methods: We included 358 patients (38% female; median age 51 years) who were admitted to the ED with acute chest pain and underwent 64-slice CT angiography. The cardiac CT data sets were assessed for presence and morphology of CAD and PAT. Coronary high-risk lesions were defined as >50% luminal narrowing and at least two of the following characteristics: positive remodeling, low-density plaque, and spotty calcification. PAT was defined as any pixel with CT attenuation of -190 to -30. HU within the pericardial sac. Results: Based on cardiac CT, 50% of the patients (n=180) had no CAD, 46% (n=165) had CAD without high-risk lesions, and 13 patients had CAD with high-risk lesions. The median PAT in patients with high-risk lesions was significantly higher compared to patients without high-risk lesions and without any CAD (151.9 [109.0-179.4]cm 3 vs. 110.0 [81.5-137.4]cm 3, vs. 74.8 [58.2-111.7]cm 3, respectively p=0.04 and p

Original languageEnglish (US)
Pages (from-to)129-134
Number of pages6
JournalAtherosclerosis
Volume222
Issue number1
DOIs
StatePublished - May 2012
Externally publishedYes

Fingerprint

Fats
Adipose Tissue
Pericardium
Acute Pain
Chest Pain
Coronary Artery Disease

Keywords

  • Adipose tissue
  • Cardiac CT angiography
  • Coronary artery disease
  • High-risk lesions
  • Peri-cardial fat
  • Vulnerable plaque

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Schlett, C. L., Ferencik, M., Kriegel, M. F., Bamberg, F., Ghoshhajra, B. B., Joshi, S. B., ... Hoffmann, U. (2012). Association of pericardial fat and coronary high-risk lesions as determined by cardiac CT. Atherosclerosis, 222(1), 129-134. https://doi.org/10.1016/j.atherosclerosis.2012.02.029

Association of pericardial fat and coronary high-risk lesions as determined by cardiac CT. / Schlett, Christopher L.; Ferencik, Maros; Kriegel, Matthias F.; Bamberg, Fabian; Ghoshhajra, Brian B.; Joshi, Subodh B.; Nagurney, John T.; Fox, Caroline S.; Truong, Quynh A.; Hoffmann, Udo.

In: Atherosclerosis, Vol. 222, No. 1, 05.2012, p. 129-134.

Research output: Contribution to journalArticle

Schlett, CL, Ferencik, M, Kriegel, MF, Bamberg, F, Ghoshhajra, BB, Joshi, SB, Nagurney, JT, Fox, CS, Truong, QA & Hoffmann, U 2012, 'Association of pericardial fat and coronary high-risk lesions as determined by cardiac CT', Atherosclerosis, vol. 222, no. 1, pp. 129-134. https://doi.org/10.1016/j.atherosclerosis.2012.02.029
Schlett, Christopher L. ; Ferencik, Maros ; Kriegel, Matthias F. ; Bamberg, Fabian ; Ghoshhajra, Brian B. ; Joshi, Subodh B. ; Nagurney, John T. ; Fox, Caroline S. ; Truong, Quynh A. ; Hoffmann, Udo. / Association of pericardial fat and coronary high-risk lesions as determined by cardiac CT. In: Atherosclerosis. 2012 ; Vol. 222, No. 1. pp. 129-134.
@article{29ab4be25edd4e2ca62cdc97f00ddfe9,
title = "Association of pericardial fat and coronary high-risk lesions as determined by cardiac CT",
abstract = "Objective: Pericardial adipose tissue (PAT) is a pathogenic fat depot associated with coronary atherosclerosis and cardiovascular events. We hypothesized that higher PAT is associated with coronary high-risk lesions as determined by cardiac CT. Methods: We included 358 patients (38{\%} female; median age 51 years) who were admitted to the ED with acute chest pain and underwent 64-slice CT angiography. The cardiac CT data sets were assessed for presence and morphology of CAD and PAT. Coronary high-risk lesions were defined as >50{\%} luminal narrowing and at least two of the following characteristics: positive remodeling, low-density plaque, and spotty calcification. PAT was defined as any pixel with CT attenuation of -190 to -30. HU within the pericardial sac. Results: Based on cardiac CT, 50{\%} of the patients (n=180) had no CAD, 46{\%} (n=165) had CAD without high-risk lesions, and 13 patients had CAD with high-risk lesions. The median PAT in patients with high-risk lesions was significantly higher compared to patients without high-risk lesions and without any CAD (151.9 [109.0-179.4]cm 3 vs. 110.0 [81.5-137.4]cm 3, vs. 74.8 [58.2-111.7]cm 3, respectively p=0.04 and p",
keywords = "Adipose tissue, Cardiac CT angiography, Coronary artery disease, High-risk lesions, Peri-cardial fat, Vulnerable plaque",
author = "Schlett, {Christopher L.} and Maros Ferencik and Kriegel, {Matthias F.} and Fabian Bamberg and Ghoshhajra, {Brian B.} and Joshi, {Subodh B.} and Nagurney, {John T.} and Fox, {Caroline S.} and Truong, {Quynh A.} and Udo Hoffmann",
year = "2012",
month = "5",
doi = "10.1016/j.atherosclerosis.2012.02.029",
language = "English (US)",
volume = "222",
pages = "129--134",
journal = "Atherosclerosis",
issn = "0021-9150",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

TY - JOUR

T1 - Association of pericardial fat and coronary high-risk lesions as determined by cardiac CT

AU - Schlett, Christopher L.

AU - Ferencik, Maros

AU - Kriegel, Matthias F.

AU - Bamberg, Fabian

AU - Ghoshhajra, Brian B.

AU - Joshi, Subodh B.

AU - Nagurney, John T.

AU - Fox, Caroline S.

AU - Truong, Quynh A.

AU - Hoffmann, Udo

PY - 2012/5

Y1 - 2012/5

N2 - Objective: Pericardial adipose tissue (PAT) is a pathogenic fat depot associated with coronary atherosclerosis and cardiovascular events. We hypothesized that higher PAT is associated with coronary high-risk lesions as determined by cardiac CT. Methods: We included 358 patients (38% female; median age 51 years) who were admitted to the ED with acute chest pain and underwent 64-slice CT angiography. The cardiac CT data sets were assessed for presence and morphology of CAD and PAT. Coronary high-risk lesions were defined as >50% luminal narrowing and at least two of the following characteristics: positive remodeling, low-density plaque, and spotty calcification. PAT was defined as any pixel with CT attenuation of -190 to -30. HU within the pericardial sac. Results: Based on cardiac CT, 50% of the patients (n=180) had no CAD, 46% (n=165) had CAD without high-risk lesions, and 13 patients had CAD with high-risk lesions. The median PAT in patients with high-risk lesions was significantly higher compared to patients without high-risk lesions and without any CAD (151.9 [109.0-179.4]cm 3 vs. 110.0 [81.5-137.4]cm 3, vs. 74.8 [58.2-111.7]cm 3, respectively p=0.04 and p

AB - Objective: Pericardial adipose tissue (PAT) is a pathogenic fat depot associated with coronary atherosclerosis and cardiovascular events. We hypothesized that higher PAT is associated with coronary high-risk lesions as determined by cardiac CT. Methods: We included 358 patients (38% female; median age 51 years) who were admitted to the ED with acute chest pain and underwent 64-slice CT angiography. The cardiac CT data sets were assessed for presence and morphology of CAD and PAT. Coronary high-risk lesions were defined as >50% luminal narrowing and at least two of the following characteristics: positive remodeling, low-density plaque, and spotty calcification. PAT was defined as any pixel with CT attenuation of -190 to -30. HU within the pericardial sac. Results: Based on cardiac CT, 50% of the patients (n=180) had no CAD, 46% (n=165) had CAD without high-risk lesions, and 13 patients had CAD with high-risk lesions. The median PAT in patients with high-risk lesions was significantly higher compared to patients without high-risk lesions and without any CAD (151.9 [109.0-179.4]cm 3 vs. 110.0 [81.5-137.4]cm 3, vs. 74.8 [58.2-111.7]cm 3, respectively p=0.04 and p

KW - Adipose tissue

KW - Cardiac CT angiography

KW - Coronary artery disease

KW - High-risk lesions

KW - Peri-cardial fat

KW - Vulnerable plaque

UR - http://www.scopus.com/inward/record.url?scp=84859820005&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84859820005&partnerID=8YFLogxK

U2 - 10.1016/j.atherosclerosis.2012.02.029

DO - 10.1016/j.atherosclerosis.2012.02.029

M3 - Article

C2 - 22417843

AN - SCOPUS:84859820005

VL - 222

SP - 129

EP - 134

JO - Atherosclerosis

JF - Atherosclerosis

SN - 0021-9150

IS - 1

ER -