Association of Parkinson's disease with accelerated bone loss, fractures and mortality in older men: The Osteoporotic Fractures in Men (MrOS) study

H. A. Fink, M. A. Kuskowski, B. C. Taylor, J. T. Schousboe, Eric Orwoll, K. E. Ensrud

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Summary: Among community-dwelling older men, compared to those without Parkinson's disease (PD), over approximately 5 years, those with baseline PD had a significantly greater rate of annualized total hip bone loss (-1.1% vs. 0.4%), proportion of incident non-spine fractures (14.9% vs. 7.2%) and mortality (34.8% vs. 9.5%). Introduction: The objective of this study was to examine the association of Parkinson's disease (PD) with bone loss and fractures in older men. Methods: This prospective cohort study analyzed data from 5,937 community dwelling men aged ≥65 years at six clinical centers of the Osteoporotic Fractures in Men (MrOS) Study. At baseline and visit two (mean interval 4.6 +/-0.4 SD years), community-diagnosed PD was ascertained by self-report and hip bone mineral density (BMD) was measured using dual energy x-ray absorptiometry (DXA). Incident fractures were self-reported. Fractures and deaths were centrally adjudicated. Results: At baseline, 46 (0.8%) men had PD. Age-adjusted mean annualized total hip bone loss was greater in men with vs. those without PD (-1.08% vs. -0.36%, p

Original languageEnglish (US)
Pages (from-to)1277-1282
Number of pages6
JournalOsteoporosis International
Volume19
Issue number9
DOIs
StatePublished - Sep 2008

Fingerprint

Osteoporotic Fractures
Bone Fractures
Parkinson Disease
Pelvic Bones
Mortality
Independent Living
Bone Density
Self Report
Cohort Studies
X-Rays
Prospective Studies

Keywords

  • Bone density
  • Fractures
  • Mortality
  • Osteoporosis
  • Parkinson's disease

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Association of Parkinson's disease with accelerated bone loss, fractures and mortality in older men : The Osteoporotic Fractures in Men (MrOS) study. / Fink, H. A.; Kuskowski, M. A.; Taylor, B. C.; Schousboe, J. T.; Orwoll, Eric; Ensrud, K. E.

In: Osteoporosis International, Vol. 19, No. 9, 09.2008, p. 1277-1282.

Research output: Contribution to journalArticle

Fink, H. A. ; Kuskowski, M. A. ; Taylor, B. C. ; Schousboe, J. T. ; Orwoll, Eric ; Ensrud, K. E. / Association of Parkinson's disease with accelerated bone loss, fractures and mortality in older men : The Osteoporotic Fractures in Men (MrOS) study. In: Osteoporosis International. 2008 ; Vol. 19, No. 9. pp. 1277-1282.
@article{785d57db2b7d498a9312286ad9348b34,
title = "Association of Parkinson's disease with accelerated bone loss, fractures and mortality in older men: The Osteoporotic Fractures in Men (MrOS) study",
abstract = "Summary: Among community-dwelling older men, compared to those without Parkinson's disease (PD), over approximately 5 years, those with baseline PD had a significantly greater rate of annualized total hip bone loss (-1.1{\%} vs. 0.4{\%}), proportion of incident non-spine fractures (14.9{\%} vs. 7.2{\%}) and mortality (34.8{\%} vs. 9.5{\%}). Introduction: The objective of this study was to examine the association of Parkinson's disease (PD) with bone loss and fractures in older men. Methods: This prospective cohort study analyzed data from 5,937 community dwelling men aged ≥65 years at six clinical centers of the Osteoporotic Fractures in Men (MrOS) Study. At baseline and visit two (mean interval 4.6 +/-0.4 SD years), community-diagnosed PD was ascertained by self-report and hip bone mineral density (BMD) was measured using dual energy x-ray absorptiometry (DXA). Incident fractures were self-reported. Fractures and deaths were centrally adjudicated. Results: At baseline, 46 (0.8{\%}) men had PD. Age-adjusted mean annualized total hip bone loss was greater in men with vs. those without PD (-1.08{\%} vs. -0.36{\%}, p",
keywords = "Bone density, Fractures, Mortality, Osteoporosis, Parkinson's disease",
author = "Fink, {H. A.} and Kuskowski, {M. A.} and Taylor, {B. C.} and Schousboe, {J. T.} and Eric Orwoll and Ensrud, {K. E.}",
year = "2008",
month = "9",
doi = "10.1007/s00198-008-0584-4",
language = "English (US)",
volume = "19",
pages = "1277--1282",
journal = "Osteoporosis International",
issn = "0937-941X",
publisher = "Springer London",
number = "9",

}

TY - JOUR

T1 - Association of Parkinson's disease with accelerated bone loss, fractures and mortality in older men

T2 - The Osteoporotic Fractures in Men (MrOS) study

AU - Fink, H. A.

AU - Kuskowski, M. A.

AU - Taylor, B. C.

AU - Schousboe, J. T.

AU - Orwoll, Eric

AU - Ensrud, K. E.

PY - 2008/9

Y1 - 2008/9

N2 - Summary: Among community-dwelling older men, compared to those without Parkinson's disease (PD), over approximately 5 years, those with baseline PD had a significantly greater rate of annualized total hip bone loss (-1.1% vs. 0.4%), proportion of incident non-spine fractures (14.9% vs. 7.2%) and mortality (34.8% vs. 9.5%). Introduction: The objective of this study was to examine the association of Parkinson's disease (PD) with bone loss and fractures in older men. Methods: This prospective cohort study analyzed data from 5,937 community dwelling men aged ≥65 years at six clinical centers of the Osteoporotic Fractures in Men (MrOS) Study. At baseline and visit two (mean interval 4.6 +/-0.4 SD years), community-diagnosed PD was ascertained by self-report and hip bone mineral density (BMD) was measured using dual energy x-ray absorptiometry (DXA). Incident fractures were self-reported. Fractures and deaths were centrally adjudicated. Results: At baseline, 46 (0.8%) men had PD. Age-adjusted mean annualized total hip bone loss was greater in men with vs. those without PD (-1.08% vs. -0.36%, p

AB - Summary: Among community-dwelling older men, compared to those without Parkinson's disease (PD), over approximately 5 years, those with baseline PD had a significantly greater rate of annualized total hip bone loss (-1.1% vs. 0.4%), proportion of incident non-spine fractures (14.9% vs. 7.2%) and mortality (34.8% vs. 9.5%). Introduction: The objective of this study was to examine the association of Parkinson's disease (PD) with bone loss and fractures in older men. Methods: This prospective cohort study analyzed data from 5,937 community dwelling men aged ≥65 years at six clinical centers of the Osteoporotic Fractures in Men (MrOS) Study. At baseline and visit two (mean interval 4.6 +/-0.4 SD years), community-diagnosed PD was ascertained by self-report and hip bone mineral density (BMD) was measured using dual energy x-ray absorptiometry (DXA). Incident fractures were self-reported. Fractures and deaths were centrally adjudicated. Results: At baseline, 46 (0.8%) men had PD. Age-adjusted mean annualized total hip bone loss was greater in men with vs. those without PD (-1.08% vs. -0.36%, p

KW - Bone density

KW - Fractures

KW - Mortality

KW - Osteoporosis

KW - Parkinson's disease

UR - http://www.scopus.com/inward/record.url?scp=49549123541&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=49549123541&partnerID=8YFLogxK

U2 - 10.1007/s00198-008-0584-4

DO - 10.1007/s00198-008-0584-4

M3 - Article

C2 - 18301854

AN - SCOPUS:49549123541

VL - 19

SP - 1277

EP - 1282

JO - Osteoporosis International

JF - Osteoporosis International

SN - 0937-941X

IS - 9

ER -