Association of incident hip fracture with the estimated femoral strength by finite element analysis of DXA scans in the Osteoporotic Fractures in Men (MrOS) study

L. Yang, N. Parimi, E. S. Orwoll, D. M. Black, J. T. Schousboe, R. Eastell, for the Osteoporotic Fractures in Men (MrOS) Study Research Group

Research output: Contribution to journalArticle

Abstract

Summary: Finite element model can estimate bone strength better than BMD. This study used such a model to determine its association with hip fracture risk and found that the strength estimate provided limited improvement over the hip BMDs in predicting femoral neck (FN) fracture risk only. Introduction: Bone fractures occur only when it is loaded beyond its ultimate strength. The goal of this study was to determine the association of femoral strength, as estimated by finite element (FE) analysis of DXA scans, with incident hip fracture as a single condition or with femoral neck (FN) and trochanter (TR) fractures separately in older men. Methods: This prospective case-cohort study included 91 FN and 64 TR fracture cases and a random sample of 500 men (14 had a hip fracture) from the Osteoporotic Fractures in Men study during a mean ± SD follow-up of 7.7 ± 2.2 years. We analysed the baseline DXA scans of the hip using a validated plane-stress, linear-elastic FE model of the proximal femur and estimated the femoral strength during a sideways fall. Results: The estimated strength was significantly (P < 0.05) associated with hip fracture independent of the TR and total hip (TH) BMDs but not FN BMD, and combining the strength with BMD did not improve the hip fracture prediction. The strength estimate was associated with FN fractures independent of the FN, TR and TH BMDs; the age-BMI-BMD adjusted hazard ratio (95% CI) per SD decrease of the strength was 1.68 (1.07–2.64), 2.38 (1.57, 3.61) and 2.04 (1.34, 3.11), respectively. This association with FN fracture was as strong as FN BMD (Harrell’s C index for the strength 0.81 vs. FN BMD 0.81) and stronger than TR and TH BMDs (0.8 vs. 0.78 and 0.81 vs. 0.79). The strength’s association with TR fracture was not independent of hip BMD. Conclusions: Although the strength estimate provided additional information over the hip BMDs, its improvement in predictive ability over the hip BMDs was confined to FN fracture only and limited.

LanguageEnglish (US)
Pages1-9
Number of pages9
JournalOsteoporosis International
DOIs
StateAccepted/In press - Nov 22 2017

Fingerprint

Finite Element Analysis
Osteoporotic Fractures
Photon Absorptiometry
Hip Fractures
Thigh
Hip
Femur
Femoral Neck Fractures
Femur Neck
Bone Fractures
Cohort Studies
Bone and Bones

Keywords

  • Bone strength
  • Finite element analysis
  • Hip fracture
  • Osteoporosis

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Yang, L., Parimi, N., Orwoll, E. S., Black, D. M., Schousboe, J. T., Eastell, R., & for the Osteoporotic Fractures in Men (MrOS) Study Research Group (2017). Association of incident hip fracture with the estimated femoral strength by finite element analysis of DXA scans in the Osteoporotic Fractures in Men (MrOS) study. Osteoporosis International, 1-9. DOI: 10.1007/s00198-017-4319-2

Association of incident hip fracture with the estimated femoral strength by finite element analysis of DXA scans in the Osteoporotic Fractures in Men (MrOS) study. / Yang, L.; Parimi, N.; Orwoll, E. S.; Black, D. M.; Schousboe, J. T.; Eastell, R.; for the Osteoporotic Fractures in Men (MrOS) Study Research Group.

In: Osteoporosis International, 22.11.2017, p. 1-9.

Research output: Contribution to journalArticle

Yang, L, Parimi, N, Orwoll, ES, Black, DM, Schousboe, JT, Eastell, R & for the Osteoporotic Fractures in Men (MrOS) Study Research Group 2017, 'Association of incident hip fracture with the estimated femoral strength by finite element analysis of DXA scans in the Osteoporotic Fractures in Men (MrOS) study' Osteoporosis International, pp. 1-9. DOI: 10.1007/s00198-017-4319-2
Yang, L. ; Parimi, N. ; Orwoll, E. S. ; Black, D. M. ; Schousboe, J. T. ; Eastell, R. ; for the Osteoporotic Fractures in Men (MrOS) Study Research Group. / Association of incident hip fracture with the estimated femoral strength by finite element analysis of DXA scans in the Osteoporotic Fractures in Men (MrOS) study. In: Osteoporosis International. 2017 ; pp. 1-9
@article{8b68c9b0dc2148d4bac568326304eb80,
title = "Association of incident hip fracture with the estimated femoral strength by finite element analysis of DXA scans in the Osteoporotic Fractures in Men (MrOS) study",
abstract = "Summary: Finite element model can estimate bone strength better than BMD. This study used such a model to determine its association with hip fracture risk and found that the strength estimate provided limited improvement over the hip BMDs in predicting femoral neck (FN) fracture risk only. Introduction: Bone fractures occur only when it is loaded beyond its ultimate strength. The goal of this study was to determine the association of femoral strength, as estimated by finite element (FE) analysis of DXA scans, with incident hip fracture as a single condition or with femoral neck (FN) and trochanter (TR) fractures separately in older men. Methods: This prospective case-cohort study included 91 FN and 64 TR fracture cases and a random sample of 500 men (14 had a hip fracture) from the Osteoporotic Fractures in Men study during a mean ± SD follow-up of 7.7 ± 2.2 years. We analysed the baseline DXA scans of the hip using a validated plane-stress, linear-elastic FE model of the proximal femur and estimated the femoral strength during a sideways fall. Results: The estimated strength was significantly (P < 0.05) associated with hip fracture independent of the TR and total hip (TH) BMDs but not FN BMD, and combining the strength with BMD did not improve the hip fracture prediction. The strength estimate was associated with FN fractures independent of the FN, TR and TH BMDs; the age-BMI-BMD adjusted hazard ratio (95\{%} CI) per SD decrease of the strength was 1.68 (1.07–2.64), 2.38 (1.57, 3.61) and 2.04 (1.34, 3.11), respectively. This association with FN fracture was as strong as FN BMD (Harrell’s C index for the strength 0.81 vs. FN BMD 0.81) and stronger than TR and TH BMDs (0.8 vs. 0.78 and 0.81 vs. 0.79). The strength’s association with TR fracture was not independent of hip BMD. Conclusions: Although the strength estimate provided additional information over the hip BMDs, its improvement in predictive ability over the hip BMDs was confined to FN fracture only and limited.",
keywords = "Bone strength, Finite element analysis, Hip fracture, Osteoporosis",
author = "L. Yang and N. Parimi and Orwoll, {E. S.} and Black, {D. M.} and Schousboe, {J. T.} and R. Eastell and {for the Osteoporotic Fractures in Men (MrOS) Study Research Group}",
year = "2017",
month = "11",
day = "22",
doi = "10.1007/s00198-017-4319-2",
language = "English (US)",
pages = "1--9",
journal = "Osteoporosis International",
issn = "0937-941X",
publisher = "Springer London",

}

TY - JOUR

T1 - Association of incident hip fracture with the estimated femoral strength by finite element analysis of DXA scans in the Osteoporotic Fractures in Men (MrOS) study

AU - Yang,L.

AU - Parimi,N.

AU - Orwoll,E. S.

AU - Black,D. M.

AU - Schousboe,J. T.

AU - Eastell,R.

AU - for the Osteoporotic Fractures in Men (MrOS) Study Research Group

PY - 2017/11/22

Y1 - 2017/11/22

N2 - Summary: Finite element model can estimate bone strength better than BMD. This study used such a model to determine its association with hip fracture risk and found that the strength estimate provided limited improvement over the hip BMDs in predicting femoral neck (FN) fracture risk only. Introduction: Bone fractures occur only when it is loaded beyond its ultimate strength. The goal of this study was to determine the association of femoral strength, as estimated by finite element (FE) analysis of DXA scans, with incident hip fracture as a single condition or with femoral neck (FN) and trochanter (TR) fractures separately in older men. Methods: This prospective case-cohort study included 91 FN and 64 TR fracture cases and a random sample of 500 men (14 had a hip fracture) from the Osteoporotic Fractures in Men study during a mean ± SD follow-up of 7.7 ± 2.2 years. We analysed the baseline DXA scans of the hip using a validated plane-stress, linear-elastic FE model of the proximal femur and estimated the femoral strength during a sideways fall. Results: The estimated strength was significantly (P < 0.05) associated with hip fracture independent of the TR and total hip (TH) BMDs but not FN BMD, and combining the strength with BMD did not improve the hip fracture prediction. The strength estimate was associated with FN fractures independent of the FN, TR and TH BMDs; the age-BMI-BMD adjusted hazard ratio (95% CI) per SD decrease of the strength was 1.68 (1.07–2.64), 2.38 (1.57, 3.61) and 2.04 (1.34, 3.11), respectively. This association with FN fracture was as strong as FN BMD (Harrell’s C index for the strength 0.81 vs. FN BMD 0.81) and stronger than TR and TH BMDs (0.8 vs. 0.78 and 0.81 vs. 0.79). The strength’s association with TR fracture was not independent of hip BMD. Conclusions: Although the strength estimate provided additional information over the hip BMDs, its improvement in predictive ability over the hip BMDs was confined to FN fracture only and limited.

AB - Summary: Finite element model can estimate bone strength better than BMD. This study used such a model to determine its association with hip fracture risk and found that the strength estimate provided limited improvement over the hip BMDs in predicting femoral neck (FN) fracture risk only. Introduction: Bone fractures occur only when it is loaded beyond its ultimate strength. The goal of this study was to determine the association of femoral strength, as estimated by finite element (FE) analysis of DXA scans, with incident hip fracture as a single condition or with femoral neck (FN) and trochanter (TR) fractures separately in older men. Methods: This prospective case-cohort study included 91 FN and 64 TR fracture cases and a random sample of 500 men (14 had a hip fracture) from the Osteoporotic Fractures in Men study during a mean ± SD follow-up of 7.7 ± 2.2 years. We analysed the baseline DXA scans of the hip using a validated plane-stress, linear-elastic FE model of the proximal femur and estimated the femoral strength during a sideways fall. Results: The estimated strength was significantly (P < 0.05) associated with hip fracture independent of the TR and total hip (TH) BMDs but not FN BMD, and combining the strength with BMD did not improve the hip fracture prediction. The strength estimate was associated with FN fractures independent of the FN, TR and TH BMDs; the age-BMI-BMD adjusted hazard ratio (95% CI) per SD decrease of the strength was 1.68 (1.07–2.64), 2.38 (1.57, 3.61) and 2.04 (1.34, 3.11), respectively. This association with FN fracture was as strong as FN BMD (Harrell’s C index for the strength 0.81 vs. FN BMD 0.81) and stronger than TR and TH BMDs (0.8 vs. 0.78 and 0.81 vs. 0.79). The strength’s association with TR fracture was not independent of hip BMD. Conclusions: Although the strength estimate provided additional information over the hip BMDs, its improvement in predictive ability over the hip BMDs was confined to FN fracture only and limited.

KW - Bone strength

KW - Finite element analysis

KW - Hip fracture

KW - Osteoporosis

UR - http://www.scopus.com/inward/record.url?scp=85034643729&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85034643729&partnerID=8YFLogxK

U2 - 10.1007/s00198-017-4319-2

DO - 10.1007/s00198-017-4319-2

M3 - Article

SP - 1

EP - 9

JO - Osteoporosis International

T2 - Osteoporosis International

JF - Osteoporosis International

SN - 0937-941X

ER -