Association of fungal infection and increased mortality in liver transplant recipients

John M. Rabkin, Susan L. Oroloff, Christopher Corless, Kent G. Benner, Ken D. Flora, Hugo R. Rosen, Ali J. Olyaei

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

Background: Invasive fungal infection is associated with increased morbidity and mortality following orthotopic liver transplantation (OLTx). Understanding the risk factors associated with fungal infection may facilitate identification of high-risk patients and guide appropriate initiation of antifungal therapy. Objectives: The aim of this study was to determine the incidence of fungal infections, identify the most common fungal pathogens, and determine the risk factors associated with fungal infections and mortality in OLTx recipients. Methods: Medical records from 96 consecutive OLTx in 90 American veterans (88 males, 2 females; mean age 48 years, range 32 to 67) performed from January 1994 to December 1997 were retrospectively reviewed for fungal infection in the first 120 days after transplantation. Infection was defined by positive cultures from either blood, urine (2.5 mg/dL), biliary/vascular complications, and retransplantation. Conclusions: Fungal infections were associated with increased morbidity and mortality following OLTx, with Candida albicans being the most common pathogen. Treatment strategies involving antifungal prophylaxis for high-risk patients and earlier initiation of antifungal therapy in cases of presumed infection are warranted. (C) 2000 by Excerpta Medica, Inc.

Original languageEnglish (US)
Pages (from-to)426-430
Number of pages5
JournalAmerican Journal of Surgery
Volume179
Issue number5
DOIs
StatePublished - May 15 2000

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Mycoses
Mortality
Liver
Morbidity
Veterans
Infection
Candida albicans
Liver Transplantation
Medical Records
Blood Vessels
Therapeutics
Transplantation
Transplant Recipients
Urine
Incidence

ASJC Scopus subject areas

  • Surgery

Cite this

Rabkin, J. M., Oroloff, S. L., Corless, C., Benner, K. G., Flora, K. D., Rosen, H. R., & Olyaei, A. J. (2000). Association of fungal infection and increased mortality in liver transplant recipients. American Journal of Surgery, 179(5), 426-430. https://doi.org/10.1016/S0002-9610(00)00366-4

Association of fungal infection and increased mortality in liver transplant recipients. / Rabkin, John M.; Oroloff, Susan L.; Corless, Christopher; Benner, Kent G.; Flora, Ken D.; Rosen, Hugo R.; Olyaei, Ali J.

In: American Journal of Surgery, Vol. 179, No. 5, 15.05.2000, p. 426-430.

Research output: Contribution to journalArticle

Rabkin, John M. ; Oroloff, Susan L. ; Corless, Christopher ; Benner, Kent G. ; Flora, Ken D. ; Rosen, Hugo R. ; Olyaei, Ali J. / Association of fungal infection and increased mortality in liver transplant recipients. In: American Journal of Surgery. 2000 ; Vol. 179, No. 5. pp. 426-430.
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AU - Rosen, Hugo R.

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