Association of fibrinogen and coagulation factors VII and VIII with cardiovascular risk factors in the elderly: The Cardiovascular Health Study

Mary Cushman, Norbert Yanez, Bruce M. Psaty, Linda P. Fried, Gerardo Heiss, Marshal Lee, Joseph F. Polak, Peter J. Savage, Russell P. Tracy

Research output: Contribution to journalArticle

106 Citations (Scopus)

Abstract

The cross-sectional correlates of three hemostatic factors-fibrinogen, factor VII, and factor VIII-were examined in the Cardiovascular Health Study, a population-based cohort study of 5,201 subjects over age 65 years. Subjects were recruited in 1989-1990 in Forsyth County, North Carolina; Sacramento County, California; Washington County, Maryland; and Pittsburgh, Pennsylvania. In multivariate linear regression models, cardiac risk factors significantly associated with fibrinogen were current smoking, race, lipids, and white blood count. In women, alcohol use, obesity, physical activity, and insulin level were also significant, while in men hypertension was correlated. The significant correlates of factor VII were lipids and white blood count in men and estrogen use, alcohol use, race, lipids, insulin level, white blood count, and obesity in women. The independent correlates of factor VIII were insulin, glucose, and race in both sexes; low density lipoprotein cholesterol, white blood count, and diuretic use in men; and alcohol use in women. In multivariate models, factors known to be modifiable risk factors for cardiovascular disease accounted for more of the population variance of these hemostatic factors in women than in men, especially for factor VII. The hemostatic factors may mediate some effects of risk factors on disease, and this should be considered in longitudinal studies.

Original languageEnglish (US)
Pages (from-to)665-676
Number of pages12
JournalAmerican Journal of Epidemiology
Volume143
Issue number7
StatePublished - Apr 1 1996
Externally publishedYes

Fingerprint

Factor VII
Factor VIII
Fibrinogen
Hemostatics
Alcohols
Health
Insulin
Lipids
Linear Models
Obesity
Diuretics
LDL Cholesterol
Population
Longitudinal Studies
Estrogens
Cohort Studies
Cardiovascular Diseases
Smoking
Exercise
Hypertension

Keywords

  • aged
  • blood coagulation factors
  • cardiovascular disease
  • risk factors

ASJC Scopus subject areas

  • Epidemiology

Cite this

Association of fibrinogen and coagulation factors VII and VIII with cardiovascular risk factors in the elderly : The Cardiovascular Health Study. / Cushman, Mary; Yanez, Norbert; Psaty, Bruce M.; Fried, Linda P.; Heiss, Gerardo; Lee, Marshal; Polak, Joseph F.; Savage, Peter J.; Tracy, Russell P.

In: American Journal of Epidemiology, Vol. 143, No. 7, 01.04.1996, p. 665-676.

Research output: Contribution to journalArticle

Cushman, M, Yanez, N, Psaty, BM, Fried, LP, Heiss, G, Lee, M, Polak, JF, Savage, PJ & Tracy, RP 1996, 'Association of fibrinogen and coagulation factors VII and VIII with cardiovascular risk factors in the elderly: The Cardiovascular Health Study', American Journal of Epidemiology, vol. 143, no. 7, pp. 665-676.
Cushman, Mary ; Yanez, Norbert ; Psaty, Bruce M. ; Fried, Linda P. ; Heiss, Gerardo ; Lee, Marshal ; Polak, Joseph F. ; Savage, Peter J. ; Tracy, Russell P. / Association of fibrinogen and coagulation factors VII and VIII with cardiovascular risk factors in the elderly : The Cardiovascular Health Study. In: American Journal of Epidemiology. 1996 ; Vol. 143, No. 7. pp. 665-676.
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