Association of cognitive domains with postural instability/gait disturbance in Parkinson's disease

V. E. Kelly; C. O. Johnson; E. L. McGough; A. Shumway-Cook; F. B. Horak; K. A. Chung; A. J. Espay; F. J. Revilla; J. Devoto; C. Wood-Siverio; S. A. Factor; B. Cholerton; K. L. Edwards; A. L. Peterson; J. F. Quinn; T. J. Montine; C. P. Zabetian; J. B. Leverenz

doi:10.1016/j.parkreldis.2015.04.002

Association of cognitive domains with postural instability/gait disturbance in Parkinson's disease

V. E. Kelly, C. O. Johnson, E. L. McGough, A. Shumway-Cook, F. B. Horak, K. A. Chung, A. J. Espay, F. J. Revilla, J. Devoto, C. Wood-Siverio, S. A. Factor, B. Cholerton, K. L. Edwards, A. L. Peterson, J. F. Quinn, T. J. Montine, C. P. Zabetian, J. B. Leverenz

Neurology

Research output: Contribution to journal › Article › peer-review

70 Scopus citations

Abstract

Introduction: Research suggests an association between global cognition and postural instability/gait disturbance (PIGD) in Parkinson disease (PD), but the relationship between specific cognitive domains and PIGD symptoms is not clear. This study examined the association of cognition (global and specific cognitive domains) with PIGD symptoms in a large, well-characterized sample of individuals with PD. Methods: Cognitive function was measured with a detailed neuropsychological assessment, including global cognition, executive function, memory, visuospatial function, and language. PIGD symptoms were measured using the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Part III, Motor Examination subscale. Multiple linear regression analyses were performed to assess the relationship between cognition and PIGD symptoms with models adjusting for age, sex, education, enrollment site, disease duration, and motor symptom severity. Results: The analysis included 783 participants, with mean (standard deviation) age of 67.3 (9.7) years and median (interquartile range) MDS-UPDRS Motor Subscale score of 26 (17, 35). Deficits in global cognition, executive function, memory, and phonemic fluency were associated with more severe PIGD symptoms. Deficits in executive function were associated with impairments in gait, freezing, and postural stability, while visuospatial impairments were associated only with more severe freezing, and poorer memory function was associated only with greater postural instability. Discussion: While impairments in global cognition and aspects of executive functioning were associated with more severe PIGD symptoms, specific cognitive domains were differentially related to distinct PIGD components, suggesting the presence of multiple neural pathways contributing to associations between cognition and PIGD symptoms in persons with PD.

Original language	English (US)
Pages (from-to)	692-697
Number of pages	6
Journal	Parkinsonism and Related Disorders
Volume	21
Issue number	7
DOIs	https://doi.org/10.1016/j.parkreldis.2015.04.002
State	Published - Jul 1 2015

Keywords

Balance
Cognition
Executive function
Freezing of gait
Gait

ASJC Scopus subject areas

Neurology
Geriatrics and Gerontology
Clinical Neurology

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10.1016/j.parkreldis.2015.04.002

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Kelly, V. E., Johnson, C. O., McGough, E. L., Shumway-Cook, A., Horak, F. B., Chung, K. A., Espay, A. J., Revilla, F. J., Devoto, J., Wood-Siverio, C., Factor, S. A., Cholerton, B., Edwards, K. L., Peterson, A. L., Quinn, J. F., Montine, T. J., Zabetian, C. P., & Leverenz, J. B. (2015). Association of cognitive domains with postural instability/gait disturbance in Parkinson's disease. Parkinsonism and Related Disorders, 21(7), 692-697. https://doi.org/10.1016/j.parkreldis.2015.04.002

Kelly, VE, Johnson, CO, McGough, EL, Shumway-Cook, A, Horak, FB , Chung, KA, Espay, AJ, Revilla, FJ, Devoto, J, Wood-Siverio, C, Factor, SA, Cholerton, B, Edwards, KL, Peterson, AL , Quinn, JF, Montine, TJ, Zabetian, CP & Leverenz, JB 2015, 'Association of cognitive domains with postural instability/gait disturbance in Parkinson's disease', Parkinsonism and Related Disorders, vol. 21, no. 7, pp. 692-697. https://doi.org/10.1016/j.parkreldis.2015.04.002

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title = "Association of cognitive domains with postural instability/gait disturbance in Parkinson's disease",

abstract = "Introduction: Research suggests an association between global cognition and postural instability/gait disturbance (PIGD) in Parkinson disease (PD), but the relationship between specific cognitive domains and PIGD symptoms is not clear. This study examined the association of cognition (global and specific cognitive domains) with PIGD symptoms in a large, well-characterized sample of individuals with PD. Methods: Cognitive function was measured with a detailed neuropsychological assessment, including global cognition, executive function, memory, visuospatial function, and language. PIGD symptoms were measured using the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Part III, Motor Examination subscale. Multiple linear regression analyses were performed to assess the relationship between cognition and PIGD symptoms with models adjusting for age, sex, education, enrollment site, disease duration, and motor symptom severity. Results: The analysis included 783 participants, with mean (standard deviation) age of 67.3 (9.7) years and median (interquartile range) MDS-UPDRS Motor Subscale score of 26 (17, 35). Deficits in global cognition, executive function, memory, and phonemic fluency were associated with more severe PIGD symptoms. Deficits in executive function were associated with impairments in gait, freezing, and postural stability, while visuospatial impairments were associated only with more severe freezing, and poorer memory function was associated only with greater postural instability. Discussion: While impairments in global cognition and aspects of executive functioning were associated with more severe PIGD symptoms, specific cognitive domains were differentially related to distinct PIGD components, suggesting the presence of multiple neural pathways contributing to associations between cognition and PIGD symptoms in persons with PD.",

keywords = "Balance, Cognition, Executive function, Freezing of gait, Gait",

author = "Kelly, {V. E.} and Johnson, {C. O.} and McGough, {E. L.} and A. Shumway-Cook and Horak, {F. B.} and Chung, {K. A.} and Espay, {A. J.} and Revilla, {F. J.} and J. Devoto and C. Wood-Siverio and Factor, {S. A.} and B. Cholerton and Edwards, {K. L.} and Peterson, {A. L.} and Quinn, {J. F.} and Montine, {T. J.} and Zabetian, {C. P.} and Leverenz, {J. B.}",

note = "Funding Information: This work was supported by the Department of Veterans Affairs, grants from the American Parkinson Disease Association , National Institutes of Health ( P50 NS062684 and R01 NS065070 ), Consolidated Anti-Aging Foundation, and the Jane and Lee Seidman Fund. The funding sources did not provide scientific input for this study. Publisher Copyright: {\textcopyright} 2015 Elsevier Ltd.",

year = "2015",

month = jul,

day = "1",

doi = "10.1016/j.parkreldis.2015.04.002",

language = "English (US)",

volume = "21",

pages = "692--697",

journal = "Parkinsonism and Related Disorders",

issn = "1353-8020",

publisher = "Elsevier BV",

number = "7",

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TY - JOUR

T1 - Association of cognitive domains with postural instability/gait disturbance in Parkinson's disease

AU - Kelly, V. E.

AU - Johnson, C. O.

AU - McGough, E. L.

AU - Shumway-Cook, A.

AU - Horak, F. B.

AU - Chung, K. A.

AU - Espay, A. J.

AU - Revilla, F. J.

AU - Devoto, J.

AU - Wood-Siverio, C.

AU - Factor, S. A.

AU - Cholerton, B.

AU - Edwards, K. L.

AU - Peterson, A. L.

AU - Quinn, J. F.

AU - Montine, T. J.

AU - Zabetian, C. P.

AU - Leverenz, J. B.

N1 - Funding Information: This work was supported by the Department of Veterans Affairs, grants from the American Parkinson Disease Association , National Institutes of Health ( P50 NS062684 and R01 NS065070 ), Consolidated Anti-Aging Foundation, and the Jane and Lee Seidman Fund. The funding sources did not provide scientific input for this study. Publisher Copyright: © 2015 Elsevier Ltd.

PY - 2015/7/1

Y1 - 2015/7/1

N2 - Introduction: Research suggests an association between global cognition and postural instability/gait disturbance (PIGD) in Parkinson disease (PD), but the relationship between specific cognitive domains and PIGD symptoms is not clear. This study examined the association of cognition (global and specific cognitive domains) with PIGD symptoms in a large, well-characterized sample of individuals with PD. Methods: Cognitive function was measured with a detailed neuropsychological assessment, including global cognition, executive function, memory, visuospatial function, and language. PIGD symptoms were measured using the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Part III, Motor Examination subscale. Multiple linear regression analyses were performed to assess the relationship between cognition and PIGD symptoms with models adjusting for age, sex, education, enrollment site, disease duration, and motor symptom severity. Results: The analysis included 783 participants, with mean (standard deviation) age of 67.3 (9.7) years and median (interquartile range) MDS-UPDRS Motor Subscale score of 26 (17, 35). Deficits in global cognition, executive function, memory, and phonemic fluency were associated with more severe PIGD symptoms. Deficits in executive function were associated with impairments in gait, freezing, and postural stability, while visuospatial impairments were associated only with more severe freezing, and poorer memory function was associated only with greater postural instability. Discussion: While impairments in global cognition and aspects of executive functioning were associated with more severe PIGD symptoms, specific cognitive domains were differentially related to distinct PIGD components, suggesting the presence of multiple neural pathways contributing to associations between cognition and PIGD symptoms in persons with PD.

AB - Introduction: Research suggests an association between global cognition and postural instability/gait disturbance (PIGD) in Parkinson disease (PD), but the relationship between specific cognitive domains and PIGD symptoms is not clear. This study examined the association of cognition (global and specific cognitive domains) with PIGD symptoms in a large, well-characterized sample of individuals with PD. Methods: Cognitive function was measured with a detailed neuropsychological assessment, including global cognition, executive function, memory, visuospatial function, and language. PIGD symptoms were measured using the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Part III, Motor Examination subscale. Multiple linear regression analyses were performed to assess the relationship between cognition and PIGD symptoms with models adjusting for age, sex, education, enrollment site, disease duration, and motor symptom severity. Results: The analysis included 783 participants, with mean (standard deviation) age of 67.3 (9.7) years and median (interquartile range) MDS-UPDRS Motor Subscale score of 26 (17, 35). Deficits in global cognition, executive function, memory, and phonemic fluency were associated with more severe PIGD symptoms. Deficits in executive function were associated with impairments in gait, freezing, and postural stability, while visuospatial impairments were associated only with more severe freezing, and poorer memory function was associated only with greater postural instability. Discussion: While impairments in global cognition and aspects of executive functioning were associated with more severe PIGD symptoms, specific cognitive domains were differentially related to distinct PIGD components, suggesting the presence of multiple neural pathways contributing to associations between cognition and PIGD symptoms in persons with PD.

KW - Balance

KW - Cognition

KW - Executive function

KW - Freezing of gait

KW - Gait

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SN - 1353-8020

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JO - Parkinsonism and Related Disorders

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Association of cognitive domains with postural instability/gait disturbance in Parkinson's disease

Abstract

Keywords

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