Abstract
Introduction: Research suggests an association between global cognition and postural instability/gait disturbance (PIGD) in Parkinson disease (PD), but the relationship between specific cognitive domains and PIGD symptoms is not clear. This study examined the association of cognition (global and specific cognitive domains) with PIGD symptoms in a large, well-characterized sample of individuals with PD. Methods: Cognitive function was measured with a detailed neuropsychological assessment, including global cognition, executive function, memory, visuospatial function, and language. PIGD symptoms were measured using the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Part III, Motor Examination subscale. Multiple linear regression analyses were performed to assess the relationship between cognition and PIGD symptoms with models adjusting for age, sex, education, enrollment site, disease duration, and motor symptom severity. Results: The analysis included 783 participants, with mean (standard deviation) age of 67.3 (9.7) years and median (interquartile range) MDS-UPDRS Motor Subscale score of 26 (17, 35). Deficits in global cognition, executive function, memory, and phonemic fluency were associated with more severe PIGD symptoms. Deficits in executive function were associated with impairments in gait, freezing, and postural stability, while visuospatial impairments were associated only with more severe freezing, and poorer memory function was associated only with greater postural instability. Discussion: While impairments in global cognition and aspects of executive functioning were associated with more severe PIGD symptoms, specific cognitive domains were differentially related to distinct PIGD components, suggesting the presence of multiple neural pathways contributing to associations between cognition and PIGD symptoms in persons with PD.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 692-697 |
| Number of pages | 6 |
| Journal | Parkinsonism and Related Disorders |
| Volume | 21 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 1 2015 |
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Keywords
- Balance
- Cognition
- Executive function
- Freezing of gait
- Gait
ASJC Scopus subject areas
- Geriatrics and Gerontology
- Clinical Neurology
- Neurology
Cite this
Association of cognitive domains with postural instability/gait disturbance in Parkinson's disease. / Kelly, V. E.; Johnson, C. O.; McGough, E. L.; Shumway-Cook, A.; Horak, Fay; Chung, Kathryn (Kathy); Espay, A. J.; Revilla, F. J.; Devoto, J.; Wood-Siverio, C.; Factor, S. A.; Cholerton, B.; Edwards, K. L.; Peterson, Amie; Quinn, Joseph; Montine, T. J.; Zabetian, C. P.; Leverenz, J. B.
In: Parkinsonism and Related Disorders, Vol. 21, No. 7, 01.07.2015, p. 692-697.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Association of cognitive domains with postural instability/gait disturbance in Parkinson's disease
AU - Kelly, V. E.
AU - Johnson, C. O.
AU - McGough, E. L.
AU - Shumway-Cook, A.
AU - Horak, Fay
AU - Chung, Kathryn (Kathy)
AU - Espay, A. J.
AU - Revilla, F. J.
AU - Devoto, J.
AU - Wood-Siverio, C.
AU - Factor, S. A.
AU - Cholerton, B.
AU - Edwards, K. L.
AU - Peterson, Amie
AU - Quinn, Joseph
AU - Montine, T. J.
AU - Zabetian, C. P.
AU - Leverenz, J. B.
PY - 2015/7/1
Y1 - 2015/7/1
N2 - Introduction: Research suggests an association between global cognition and postural instability/gait disturbance (PIGD) in Parkinson disease (PD), but the relationship between specific cognitive domains and PIGD symptoms is not clear. This study examined the association of cognition (global and specific cognitive domains) with PIGD symptoms in a large, well-characterized sample of individuals with PD. Methods: Cognitive function was measured with a detailed neuropsychological assessment, including global cognition, executive function, memory, visuospatial function, and language. PIGD symptoms were measured using the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Part III, Motor Examination subscale. Multiple linear regression analyses were performed to assess the relationship between cognition and PIGD symptoms with models adjusting for age, sex, education, enrollment site, disease duration, and motor symptom severity. Results: The analysis included 783 participants, with mean (standard deviation) age of 67.3 (9.7) years and median (interquartile range) MDS-UPDRS Motor Subscale score of 26 (17, 35). Deficits in global cognition, executive function, memory, and phonemic fluency were associated with more severe PIGD symptoms. Deficits in executive function were associated with impairments in gait, freezing, and postural stability, while visuospatial impairments were associated only with more severe freezing, and poorer memory function was associated only with greater postural instability. Discussion: While impairments in global cognition and aspects of executive functioning were associated with more severe PIGD symptoms, specific cognitive domains were differentially related to distinct PIGD components, suggesting the presence of multiple neural pathways contributing to associations between cognition and PIGD symptoms in persons with PD.
AB - Introduction: Research suggests an association between global cognition and postural instability/gait disturbance (PIGD) in Parkinson disease (PD), but the relationship between specific cognitive domains and PIGD symptoms is not clear. This study examined the association of cognition (global and specific cognitive domains) with PIGD symptoms in a large, well-characterized sample of individuals with PD. Methods: Cognitive function was measured with a detailed neuropsychological assessment, including global cognition, executive function, memory, visuospatial function, and language. PIGD symptoms were measured using the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Part III, Motor Examination subscale. Multiple linear regression analyses were performed to assess the relationship between cognition and PIGD symptoms with models adjusting for age, sex, education, enrollment site, disease duration, and motor symptom severity. Results: The analysis included 783 participants, with mean (standard deviation) age of 67.3 (9.7) years and median (interquartile range) MDS-UPDRS Motor Subscale score of 26 (17, 35). Deficits in global cognition, executive function, memory, and phonemic fluency were associated with more severe PIGD symptoms. Deficits in executive function were associated with impairments in gait, freezing, and postural stability, while visuospatial impairments were associated only with more severe freezing, and poorer memory function was associated only with greater postural instability. Discussion: While impairments in global cognition and aspects of executive functioning were associated with more severe PIGD symptoms, specific cognitive domains were differentially related to distinct PIGD components, suggesting the presence of multiple neural pathways contributing to associations between cognition and PIGD symptoms in persons with PD.
KW - Balance
KW - Cognition
KW - Executive function
KW - Freezing of gait
KW - Gait
UR - http://www.scopus.com/inward/record.url?scp=84930752214&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84930752214&partnerID=8YFLogxK
U2 - 10.1016/j.parkreldis.2015.04.002
DO - 10.1016/j.parkreldis.2015.04.002
M3 - Article
VL - 21
SP - 692
EP - 697
JO - Parkinsonism and Related Disorders
JF - Parkinsonism and Related Disorders
SN - 1353-8020
IS - 7
ER -