TY - JOUR
T1 - Association of cartilage defects, and other MRI findings with pain and function in individuals with mild-moderate radiographic hip osteoarthritis and controls
AU - Kumar, D.
AU - Wyatt, C. R.
AU - Lee, S.
AU - Nardo, L.
AU - Link, T. M.
AU - Majumdar, S.
AU - Souza, R. B.
N1 - Funding Information:
The authors thank Melissa Guan for help in recruiting and consenting patients for the study. Research reported in this publication was supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases, part of the National Institutes of Health , under Award Number NIH –NIAMS P50 AR060752 . The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health
PY - 2013/11
Y1 - 2013/11
N2 - Objective: To evaluate the relationship of hip radiographic osteoarthritis (ROA) and MRI findings of cartilage lesions, labral tears, bone marrow edema-like lesions (BMELs) and subchondral cysts with self-reported and physical function. Design: Eighty five subjects were classified as controls (n=55, Kellgren-Lawrence (KL) 0, 1) or having mild-moderate ROA (n=30, KL 2, 3). T2 weighted MRI images at 3-Twere graded for presence of cartilage lesions, labral tears, BMELs and subchondral cysts. Posterior wall sign, cross-over sign, center-edge angle and alpha angle were also recorded. Function was assessed using Hip dysfunction and Osteoarthritis Outcome Score (HOOS), Timed-Up and Go (TUG) test and Y-Balance Test (YBT). Analysis compared function between subjects with and without ROA and those with and without femoral or acetabular cartilage lesions, adjusted for age. Non-parametric correlations were used to assess the relationship between radiographic scores, MRI scores and function. Results: Subjects with acetabular cartilage lesions had worse HOOS (Difference=5-10%, P=0.036-0.004), but not TUG or YBT, scores. Acetabular cartilage lesions, BMELs and subchondral cysts were associated with worse HOOS scores (ρ=0.23-0.37, P=0.041-0.001). Differences in function between subjects with and without ROA or femoral cartilage lesions were not significant. Other radiologic findings were not associated with function. Conclusions: Acetabular cartilage defects, but not femoral cartilage defects or ROA, were associated with greater self-reported pain and disability. BMELs and subchondral cysts were related to greater hip related self-reported pain and disability. None of the radiographic or MRI features was related to physical function.
AB - Objective: To evaluate the relationship of hip radiographic osteoarthritis (ROA) and MRI findings of cartilage lesions, labral tears, bone marrow edema-like lesions (BMELs) and subchondral cysts with self-reported and physical function. Design: Eighty five subjects were classified as controls (n=55, Kellgren-Lawrence (KL) 0, 1) or having mild-moderate ROA (n=30, KL 2, 3). T2 weighted MRI images at 3-Twere graded for presence of cartilage lesions, labral tears, BMELs and subchondral cysts. Posterior wall sign, cross-over sign, center-edge angle and alpha angle were also recorded. Function was assessed using Hip dysfunction and Osteoarthritis Outcome Score (HOOS), Timed-Up and Go (TUG) test and Y-Balance Test (YBT). Analysis compared function between subjects with and without ROA and those with and without femoral or acetabular cartilage lesions, adjusted for age. Non-parametric correlations were used to assess the relationship between radiographic scores, MRI scores and function. Results: Subjects with acetabular cartilage lesions had worse HOOS (Difference=5-10%, P=0.036-0.004), but not TUG or YBT, scores. Acetabular cartilage lesions, BMELs and subchondral cysts were associated with worse HOOS scores (ρ=0.23-0.37, P=0.041-0.001). Differences in function between subjects with and without ROA or femoral cartilage lesions were not significant. Other radiologic findings were not associated with function. Conclusions: Acetabular cartilage defects, but not femoral cartilage defects or ROA, were associated with greater self-reported pain and disability. BMELs and subchondral cysts were related to greater hip related self-reported pain and disability. None of the radiographic or MRI features was related to physical function.
KW - BMEL
KW - Balance
KW - Kellgren-Lawrence
KW - Labral tears
KW - Subchondral cyst
KW - Y-Balance Test
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U2 - 10.1016/j.joca.2013.08.009
DO - 10.1016/j.joca.2013.08.009
M3 - Article
C2 - 23948977
AN - SCOPUS:84884975624
SN - 1063-4584
VL - 21
SP - 1685
EP - 1692
JO - Osteoarthritis and Cartilage
JF - Osteoarthritis and Cartilage
IS - 11
ER -