Association between Vitamin D and age-related macular degeneration in the third National Health and Nutrition Examination Survey, 1988 through 1994

Niyati Parekh, Richard J. Chappell, Amy E. Millen, Daniel Albert, Julie A. Mares

Research output: Contribution to journalArticle

103 Citations (Scopus)

Abstract

Objective: To evaluate the associations between levels of vitamin D (25-hydroxyvitamin D) in serum and prevalent age-related macular degeneration (AMD). Methods and Design: Cross-sectional associations of serum vitamin D and early and advanced AMD, assessed from nonmydriatic fundus photographs, were evaluated in the third National Health and Nutrition Examination Survey, a multistage nationally representative probability sample of noninstitutionalized individuals (N=7752; 11% with AMD). Results: Levels of serum vitamin D were inversely associated with early AMD but not advanced AMD. The odds ratio (OR) and 95% confidence interval (CI) for early AMD among participants in the highest vs lowest quintile of serum vitamin D was 0.64 (95% CI, 0.5-0.8; P trend <.001). Exploratory analyses were conducted to evaluate associations with important food and supplemental sources of vitamin D. Milk intake was inversely associated with early AMD (OR, 0.75; 95% CI, 0.6-0.9). Fish intake was inversely associated with advanced AMD(OR, 0.41; 95% CI, 0.2-0.9). Consistent use vs nonuse of vitamin D from supplements was inversely associated with earlyAMDonly in individuals who did not consume milk daily (early AMD: OR, 0.67; 95% CI, 0.5-0.9). Conclusion: This study provides evidence that vitamin Dmay protect against AMD. Additional studies are needed to confirm these findings.

Original languageEnglish (US)
Pages (from-to)661-669
Number of pages9
JournalArchives of ophthalmology
Volume125
Issue number5
DOIs
StatePublished - May 1 2007
Externally publishedYes

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Nutrition Surveys
Macular Degeneration
Vitamin D
Confidence Intervals
Odds Ratio
Serum
Milk
Sampling Studies
Vitamins
Fishes
Food

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Association between Vitamin D and age-related macular degeneration in the third National Health and Nutrition Examination Survey, 1988 through 1994. / Parekh, Niyati; Chappell, Richard J.; Millen, Amy E.; Albert, Daniel; Mares, Julie A.

In: Archives of ophthalmology, Vol. 125, No. 5, 01.05.2007, p. 661-669.

Research output: Contribution to journalArticle

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abstract = "Objective: To evaluate the associations between levels of vitamin D (25-hydroxyvitamin D) in serum and prevalent age-related macular degeneration (AMD). Methods and Design: Cross-sectional associations of serum vitamin D and early and advanced AMD, assessed from nonmydriatic fundus photographs, were evaluated in the third National Health and Nutrition Examination Survey, a multistage nationally representative probability sample of noninstitutionalized individuals (N=7752; 11{\%} with AMD). Results: Levels of serum vitamin D were inversely associated with early AMD but not advanced AMD. The odds ratio (OR) and 95{\%} confidence interval (CI) for early AMD among participants in the highest vs lowest quintile of serum vitamin D was 0.64 (95{\%} CI, 0.5-0.8; P trend <.001). Exploratory analyses were conducted to evaluate associations with important food and supplemental sources of vitamin D. Milk intake was inversely associated with early AMD (OR, 0.75; 95{\%} CI, 0.6-0.9). Fish intake was inversely associated with advanced AMD(OR, 0.41; 95{\%} CI, 0.2-0.9). Consistent use vs nonuse of vitamin D from supplements was inversely associated with earlyAMDonly in individuals who did not consume milk daily (early AMD: OR, 0.67; 95{\%} CI, 0.5-0.9). Conclusion: This study provides evidence that vitamin Dmay protect against AMD. Additional studies are needed to confirm these findings.",
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