TY - JOUR
T1 - Association between T lymphocyte sub-sets apoptosis and peripheral blood mononuclear cells oxidative stress in systemic lupus erythematosus
AU - Shah, Dilip
AU - Aggarwal, Ashish
AU - Bhatnagar, Archana
AU - Kiran, Ravi
AU - Wanchu, Ajay
PY - 2011/5/1
Y1 - 2011/5/1
N2 - Increased oxidative stress and lymphocyte apoptosis are a hallmark of the autoimmune disease systemic lupus erythematosus (SLE). However, the association between oxidative stress and T lymphocytes apoptosis has still to be elucidated in SLE. In order to appraise the interaction between oxidative stress and T lymphocyte apoptosis with the severity of disease, oxidative stress profile and T lymphocytes apoptosis were studied. Increased levels of ROS, MDA and CD4 + lymphocyte apoptosis were positively associated with disease activity while decreased levels of GSH and percentage expression of CD4 + lymphocyte were negatively associated with disease activity. The decrease in intracellular levels of GSH was negatively associated with T lymphocyte, CD4+ lymphocyte, CD8+ lymphocyte apoptosis and intracellular caspase-3 expression. The present study suggests that increased T lymphocyte sub-sets apoptosis may be mediated by decreased intracellular glutathione concentration and severity of disease might be enhanced together by over-production of ROS in SLE.
AB - Increased oxidative stress and lymphocyte apoptosis are a hallmark of the autoimmune disease systemic lupus erythematosus (SLE). However, the association between oxidative stress and T lymphocytes apoptosis has still to be elucidated in SLE. In order to appraise the interaction between oxidative stress and T lymphocyte apoptosis with the severity of disease, oxidative stress profile and T lymphocytes apoptosis were studied. Increased levels of ROS, MDA and CD4 + lymphocyte apoptosis were positively associated with disease activity while decreased levels of GSH and percentage expression of CD4 + lymphocyte were negatively associated with disease activity. The decrease in intracellular levels of GSH was negatively associated with T lymphocyte, CD4+ lymphocyte, CD8+ lymphocyte apoptosis and intracellular caspase-3 expression. The present study suggests that increased T lymphocyte sub-sets apoptosis may be mediated by decreased intracellular glutathione concentration and severity of disease might be enhanced together by over-production of ROS in SLE.
KW - Reactive oxygen species
KW - T lymphocyte sub-sets
KW - apoptosis
KW - redox system
KW - systemic lupus erythematosus
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U2 - 10.3109/10715762.2011.555765
DO - 10.3109/10715762.2011.555765
M3 - Article
C2 - 21284579
AN - SCOPUS:79952637812
VL - 45
SP - 559
EP - 567
JO - Free Radical Research
JF - Free Radical Research
SN - 1071-5762
IS - 5
ER -