Association between T lymphocyte sub-sets apoptosis and peripheral blood mononuclear cells oxidative stress in systemic lupus erythematosus

Dilip Shah, Ashish Aggarwal, Archana Bhatnagar, Ravi Kiran, Ajay Wanchu

Research output: Contribution to journalArticle

42 Scopus citations

Abstract

Increased oxidative stress and lymphocyte apoptosis are a hallmark of the autoimmune disease systemic lupus erythematosus (SLE). However, the association between oxidative stress and T lymphocytes apoptosis has still to be elucidated in SLE. In order to appraise the interaction between oxidative stress and T lymphocyte apoptosis with the severity of disease, oxidative stress profile and T lymphocytes apoptosis were studied. Increased levels of ROS, MDA and CD4 + lymphocyte apoptosis were positively associated with disease activity while decreased levels of GSH and percentage expression of CD4 + lymphocyte were negatively associated with disease activity. The decrease in intracellular levels of GSH was negatively associated with T lymphocyte, CD4+ lymphocyte, CD8+ lymphocyte apoptosis and intracellular caspase-3 expression. The present study suggests that increased T lymphocyte sub-sets apoptosis may be mediated by decreased intracellular glutathione concentration and severity of disease might be enhanced together by over-production of ROS in SLE.

Original languageEnglish (US)
Pages (from-to)559-567
Number of pages9
JournalFree Radical Research
Volume45
Issue number5
DOIs
StatePublished - May 1 2011

Keywords

  • Reactive oxygen species
  • T lymphocyte sub-sets
  • apoptosis
  • redox system
  • systemic lupus erythematosus

ASJC Scopus subject areas

  • Biochemistry

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