Abstract
Increased oxidative stress and lymphocyte apoptosis are a hallmark of the autoimmune disease systemic lupus erythematosus (SLE). However, the association between oxidative stress and T lymphocytes apoptosis has still to be elucidated in SLE. In order to appraise the interaction between oxidative stress and T lymphocyte apoptosis with the severity of disease, oxidative stress profile and T lymphocytes apoptosis were studied. Increased levels of ROS, MDA and CD4 + lymphocyte apoptosis were positively associated with disease activity while decreased levels of GSH and percentage expression of CD4 + lymphocyte were negatively associated with disease activity. The decrease in intracellular levels of GSH was negatively associated with T lymphocyte, CD4+ lymphocyte, CD8+ lymphocyte apoptosis and intracellular caspase-3 expression. The present study suggests that increased T lymphocyte sub-sets apoptosis may be mediated by decreased intracellular glutathione concentration and severity of disease might be enhanced together by over-production of ROS in SLE.
Original language | English (US) |
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Pages (from-to) | 559-567 |
Number of pages | 9 |
Journal | Free Radical Research |
Volume | 45 |
Issue number | 5 |
DOIs | |
State | Published - May 2011 |
Keywords
- Reactive oxygen species
- T lymphocyte sub-sets
- apoptosis
- redox system
- systemic lupus erythematosus
ASJC Scopus subject areas
- Biochemistry