Association between T lymphocyte sub-sets apoptosis and peripheral blood mononuclear cells oxidative stress in systemic lupus erythematosus

Dilip Shah, Ashish Aggarwal, Archana Bhatnagar, Ravi Kiran, Ajay Wanchu

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Increased oxidative stress and lymphocyte apoptosis are a hallmark of the autoimmune disease systemic lupus erythematosus (SLE). However, the association between oxidative stress and T lymphocytes apoptosis has still to be elucidated in SLE. In order to appraise the interaction between oxidative stress and T lymphocyte apoptosis with the severity of disease, oxidative stress profile and T lymphocytes apoptosis were studied. Increased levels of ROS, MDA and CD4 + lymphocyte apoptosis were positively associated with disease activity while decreased levels of GSH and percentage expression of CD4 + lymphocyte were negatively associated with disease activity. The decrease in intracellular levels of GSH was negatively associated with T lymphocyte, CD4+ lymphocyte, CD8+ lymphocyte apoptosis and intracellular caspase-3 expression. The present study suggests that increased T lymphocyte sub-sets apoptosis may be mediated by decreased intracellular glutathione concentration and severity of disease might be enhanced together by over-production of ROS in SLE.

Original languageEnglish (US)
Pages (from-to)559-567
Number of pages9
JournalFree Radical Research
Volume45
Issue number5
DOIs
StatePublished - May 2011

Fingerprint

Oxidative stress
T-cells
Systemic Lupus Erythematosus
Blood Cells
Lymphocytes
Oxidative Stress
Blood
Apoptosis
T-Lymphocytes
Caspase 3
Autoimmune Diseases
Glutathione
Association reactions

Keywords

  • apoptosis
  • Reactive oxygen species
  • redox system
  • systemic lupus erythematosus
  • T lymphocyte sub-sets

ASJC Scopus subject areas

  • Biochemistry

Cite this

Association between T lymphocyte sub-sets apoptosis and peripheral blood mononuclear cells oxidative stress in systemic lupus erythematosus. / Shah, Dilip; Aggarwal, Ashish; Bhatnagar, Archana; Kiran, Ravi; Wanchu, Ajay.

In: Free Radical Research, Vol. 45, No. 5, 05.2011, p. 559-567.

Research output: Contribution to journalArticle

Shah, Dilip ; Aggarwal, Ashish ; Bhatnagar, Archana ; Kiran, Ravi ; Wanchu, Ajay. / Association between T lymphocyte sub-sets apoptosis and peripheral blood mononuclear cells oxidative stress in systemic lupus erythematosus. In: Free Radical Research. 2011 ; Vol. 45, No. 5. pp. 559-567.
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