Association between sex steroids and cognition in elderly men

Erin S. Leblanc, Patty Y. Wang, Jeri S. Janowsky, Michelle B. Neiss, Howard A. Fink, Kristine Yaffe, Lynn Marshall, Jodi Lapidus, Marcia L. Stefanick, Eric Orwoll

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Abstract

Objective To examine the association of cognitive function with sex steroid and sex hormone binding globulin (SHBG) levels among elderly men. Design Prospective cohort study, The Osteoporotic Fractures in Men Study (MrOS), consisting of 5995 US community dwelling men of 65 years or older. Patients One thousand six hundred and two men were chosen randomly from MrOS cohort for sex steroid level measurements by Mass Spectrometry (MS) at baseline. Two thousand six hundred and twenty-three MrOS participants with sex steroids measured using RIA were also examined. Measurements Baseline and follow-up (4·5 years later) performance on two cognitive tests: Trails B (executive function and motor speed) and 3MS (global cognitive function). Baseline total testosterone and oestradiol were measured by MS. Free testosterone (free-T) and free oestradiol (free-E) were calculated. SHBG was measured by radioimmunoassay. Data were analysed using linear regression. Results Baseline free-T and free-E levels were not associated with cognitive performance or change in cognition, following adjustment for age, education, race, health status and alcohol use. Baseline SHBG levels were inversely associated with follow-up trails B (P = 0·03) and 3MS performance (P = 0·02). Higher SHBG was associated with an increased risk of cognitive decline. Total sex steroid levels were not associated with cognitive performance. Conclusions Despite large numbers of participants and rigorous sex steroid measurements, we did not observe an association between cognition and either testosterone or oestradiol levels. We conclude that endogenous sex steroids in the normal range are not related to executive function or global cognitive function in elderly men. High SHBG deserves further examination as a risk factor for cognitive decline.

Original languageEnglish (US)
Pages (from-to)393-403
Number of pages11
JournalClinical Endocrinology
Volume72
Issue number3
DOIs
StatePublished - Mar 2010

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Sex Hormone-Binding Globulin
Cognition
Steroids
Testosterone
Estradiol
Executive Function
Mass Spectrometry
Independent Living
Osteoporotic Fractures
Health Status
Radioimmunoassay
Linear Models
Reference Values
Cohort Studies
Alcohols
Prospective Studies
Education

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Leblanc, E. S., Wang, P. Y., Janowsky, J. S., Neiss, M. B., Fink, H. A., Yaffe, K., ... Orwoll, E. (2010). Association between sex steroids and cognition in elderly men. Clinical Endocrinology, 72(3), 393-403. https://doi.org/10.1111/j.1365-2265.2009.03692.x

Association between sex steroids and cognition in elderly men. / Leblanc, Erin S.; Wang, Patty Y.; Janowsky, Jeri S.; Neiss, Michelle B.; Fink, Howard A.; Yaffe, Kristine; Marshall, Lynn; Lapidus, Jodi; Stefanick, Marcia L.; Orwoll, Eric.

In: Clinical Endocrinology, Vol. 72, No. 3, 03.2010, p. 393-403.

Research output: Contribution to journalArticle

Leblanc, ES, Wang, PY, Janowsky, JS, Neiss, MB, Fink, HA, Yaffe, K, Marshall, L, Lapidus, J, Stefanick, ML & Orwoll, E 2010, 'Association between sex steroids and cognition in elderly men', Clinical Endocrinology, vol. 72, no. 3, pp. 393-403. https://doi.org/10.1111/j.1365-2265.2009.03692.x
Leblanc ES, Wang PY, Janowsky JS, Neiss MB, Fink HA, Yaffe K et al. Association between sex steroids and cognition in elderly men. Clinical Endocrinology. 2010 Mar;72(3):393-403. https://doi.org/10.1111/j.1365-2265.2009.03692.x
Leblanc, Erin S. ; Wang, Patty Y. ; Janowsky, Jeri S. ; Neiss, Michelle B. ; Fink, Howard A. ; Yaffe, Kristine ; Marshall, Lynn ; Lapidus, Jodi ; Stefanick, Marcia L. ; Orwoll, Eric. / Association between sex steroids and cognition in elderly men. In: Clinical Endocrinology. 2010 ; Vol. 72, No. 3. pp. 393-403.
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