Association between omega-3 fatty acids and serum prostate-specific antigen

Laura F. De Fina, Mary H. Bassett, Carrie E. Finley, Carolyn E. Barlow, Benjamin L. Willis, Tyler Cooper, S. Michael Clark, William Harris, Nina B. Radford

Research output: Contribution to journalArticle

Abstract

We examined the association between omega-3 fatty acids (O3FAs) and prostate-specific antigen (PSA) in a cross-sectional analysis of 6219 men examined at the Cooper Clinic from 2009 to 2013. We assayed O3FAs from red blood cell membranes and measured PSA levels in study participants. Multiple logistic regression was used to examine the association between O3FAs and PSA. The mean age of study participants was 55.5 years (SD = 9.8) with a mean PSA level of 1.31 ng/mL (SD = 1.5). Unadjusted analyses indicated that there was a slight, direct association with PSA and each of the O3FAs tested. However, after adjusting for age and body mass index (BMI), the associations were reversed but nonsignificant [odds ratio (OR) for PSA > 4 ng/mL: total omega-3 OR = 0.98 per each 1% of total fatty acids, 95% confidence interval (CI) = 0.93-1.03; docosahexaenoic acid OR = 1.01, 95% CI = 0.92-1.11; omega-3 index OR = 0.99, 95% CI = 0.93-1.05). Similar results were obtained after age and BMI adjustment when the omega-3 index was divided into undesirable (0.01-3.99%), intermediate (4.0-7.99%), and desirable ranges (≥ 8.0%). Given that the study had >80% power to detect an odds ratio 1.1, we conclude that associations between O3FAs and PSA levels are either nonexistent or quite weak in the population that this healthy sample represents.

Original languageEnglish (US)
Pages (from-to)58-62
Number of pages5
JournalNutrition and Cancer
Volume68
Issue number1
DOIs
StatePublished - Jan 2 2016
Externally publishedYes

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Omega-3 Fatty Acids
Prostate-Specific Antigen
Odds Ratio
Serum
Confidence Intervals
lissamine rhodamine B
Body Mass Index
Docosahexaenoic Acids
Fatty Acids
Cross-Sectional Studies
Erythrocytes
Logistic Models
Cell Membrane
Population

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Oncology
  • Cancer Research

Cite this

De Fina, L. F., Bassett, M. H., Finley, C. E., Barlow, C. E., Willis, B. L., Cooper, T., ... Radford, N. B. (2016). Association between omega-3 fatty acids and serum prostate-specific antigen. Nutrition and Cancer, 68(1), 58-62. https://doi.org/10.1080/01635581.2016.1115102

Association between omega-3 fatty acids and serum prostate-specific antigen. / De Fina, Laura F.; Bassett, Mary H.; Finley, Carrie E.; Barlow, Carolyn E.; Willis, Benjamin L.; Cooper, Tyler; Clark, S. Michael; Harris, William; Radford, Nina B.

In: Nutrition and Cancer, Vol. 68, No. 1, 02.01.2016, p. 58-62.

Research output: Contribution to journalArticle

De Fina, LF, Bassett, MH, Finley, CE, Barlow, CE, Willis, BL, Cooper, T, Clark, SM, Harris, W & Radford, NB 2016, 'Association between omega-3 fatty acids and serum prostate-specific antigen', Nutrition and Cancer, vol. 68, no. 1, pp. 58-62. https://doi.org/10.1080/01635581.2016.1115102
De Fina LF, Bassett MH, Finley CE, Barlow CE, Willis BL, Cooper T et al. Association between omega-3 fatty acids and serum prostate-specific antigen. Nutrition and Cancer. 2016 Jan 2;68(1):58-62. https://doi.org/10.1080/01635581.2016.1115102
De Fina, Laura F. ; Bassett, Mary H. ; Finley, Carrie E. ; Barlow, Carolyn E. ; Willis, Benjamin L. ; Cooper, Tyler ; Clark, S. Michael ; Harris, William ; Radford, Nina B. / Association between omega-3 fatty acids and serum prostate-specific antigen. In: Nutrition and Cancer. 2016 ; Vol. 68, No. 1. pp. 58-62.
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