Association between monocyte Fcγ subclass expression and acute coronary syndrome

David C. Calverley, Taya Varteresian, Elizabeth Brass, Denice D. Tsao-Wei, Susan Groshen, Wendy J. Mack, Thomas A. Buchanan, Howard N. Hodis, Alan D. Schreiber

    Research output: Contribution to journalArticlepeer-review

    6 Scopus citations

    Abstract

    Background: Atherosclerosis lesions contain abundant immunoglobulins complexed with oxidized LDL (OxLDL) that are endocytosed by macrophages to form foam cells. While recent evidence supports a role for the macrophage scavenger receptor pathway in 75-90% of OxLDL uptake, in vitro evidence suggests another potential uptake pathway could involve autoantibody binding to IgG subclass-specific Fc receptors. Objective and Methods: To address this mechanism from an in vivo standpoint, the objective of this study was to utilize flow cytometry to prospectively determine monocyte Fcγ (FcR) I, II, and III receptor expression levels in patients with acute coronary syndrome (ACS, n = 48), diabetes mellitus (DM, n = 59), or neither (C, n = 88). Results: Increased FcR I expression was found in the ACS versus DM groups [geometric mean, (95% CI) = 2.26 (2.07, 2.47) versus 1.83 (1.69, 1.98) (p < 0.001)] and versus C [1.90 (1.78, 2.03) (p = 0.005)]. Similar relationships were found with both the FcR II receptor [ACS mean = 4.57 (4.02, 5.19) versus DM 3.61 (3.22, 4.05) (p = 0.021) and versus C 3.86 (3.51, 4.24) (p = 0.09)] and FcR III receptor [ACS mean = 1.55 (1.44, 1.68) versus DM 1.36 (1.27, 1.46) (p = 0.038) and versus C 1.37 (1.30, 1.45) (p = 0.032)]. There was no difference between DM and C groups in FcR I, II or III expression. Conclusions: This in vivo data supports a possible second OxLDL-autoantibody macrophage uptake mechanism through an Fc receptor-mediated pathway and a potential relationship between atherosclerotic plaque macrophage FcR levels and ACS.

    Original languageEnglish (US)
    Article number4
    JournalImmunity and Ageing
    Volume1
    DOIs
    StatePublished - Nov 12 2004

    ASJC Scopus subject areas

    • Immunology
    • Aging

    Fingerprint Dive into the research topics of 'Association between monocyte Fcγ subclass expression and acute coronary syndrome'. Together they form a unique fingerprint.

    Cite this