Association between low bone density and stroke in elderly women

The study of osteoporotic fractures

Study of Osteoporotic Fractures Research Group

Research output: Contribution to journalArticle

152 Citations (Scopus)

Abstract

Background and Purpose: To determine whether women with low bone mineral density are at increased risk of stroke, the present study was conducted. Methods: We studied 4024 ambulatory women aged 65 years or older participating in the prospective Study of Osteoporotic Fractures. Bone mineral density was measured at baseline using single photon absorptiometry; strokes were ascertained using a computerized Medicare data base and death certificates. Results: During a mean of 1.98 years of follow-up, 83 women suffered first strokes (five fatal). Osteopenia was associated with an increased stroke risk Each SD decrease in bone mineral density at the calcaneus (0.09 g/cm2) was associated with a 1.31-fold increase in stroke (95% confidence interval, 1.03-1.65), adjusted for age, follow-up time, and several potential confounders, including diabetes, systolic blood pressure, use of alcohol, cigarettes or postmenopausal estrogens, cognitive ability, grip strength, and functional ability. The observed relation between bone density and stroke was strongest for intracerebral hemorrhages and occlusions. Conclusions: Most likely, low bone density does not cause stroke; some other process probably results in both osteopenia and cerebrovascular disease.

Original languageEnglish (US)
Pages (from-to)940-946
Number of pages7
JournalStroke
Volume24
Issue number7
StatePublished - 1993
Externally publishedYes

Fingerprint

Osteoporotic Fractures
Bone Density
Stroke
Metabolic Bone Diseases
Blood Pressure
Cerebrovascular Disorders
Calcaneus
Death Certificates
Photon Absorptiometry
Cerebral Hemorrhage
Hand Strength
Medicare
Tobacco Products
Estrogens
Alcohols
Databases
Prospective Studies
Confidence Intervals

Keywords

  • Bone diseases, metabolic
  • Osteoporosis
  • Risk factors
  • Women

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialized Nursing
  • Neuroscience(all)

Cite this

Study of Osteoporotic Fractures Research Group (1993). Association between low bone density and stroke in elderly women: The study of osteoporotic fractures. Stroke, 24(7), 940-946.

Association between low bone density and stroke in elderly women : The study of osteoporotic fractures. / Study of Osteoporotic Fractures Research Group.

In: Stroke, Vol. 24, No. 7, 1993, p. 940-946.

Research output: Contribution to journalArticle

Study of Osteoporotic Fractures Research Group 1993, 'Association between low bone density and stroke in elderly women: The study of osteoporotic fractures', Stroke, vol. 24, no. 7, pp. 940-946.
Study of Osteoporotic Fractures Research Group. / Association between low bone density and stroke in elderly women : The study of osteoporotic fractures. In: Stroke. 1993 ; Vol. 24, No. 7. pp. 940-946.
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T2 - The study of osteoporotic fractures

AU - Study of Osteoporotic Fractures Research Group

AU - Browner, Warren S.

AU - Pressman, Alice R.

AU - Nevitt, Michael C.

AU - Cauley, Jane A.

AU - Cummings, Steven R.

AU - Cummings, S.

AU - Nevitt, M.

AU - Arnaud, C.

AU - Black, D.

AU - Browner, W.

AU - Fox, C.

AU - Genant, H.

AU - Harvey, S.

AU - Hulley, S.

AU - Palermo, L.

AU - Pressman, A.

AU - Seeley, D.

AU - Sherwin, R.

AU - Scott, J.

AU - Fox, K.

AU - Lewis, J.

AU - Grimm, R.

AU - Ensrud, K.

AU - Bell, C.

AU - Mitson, E.

AU - Cauley, J.

AU - Kuller, L.

AU - Harper, L.

AU - Nasim, M.

AU - Vogt, T.

AU - Vollmer, W.

AU - Orwoll, Eric

AU - Blank, J.

AU - Packer, B.

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N2 - Background and Purpose: To determine whether women with low bone mineral density are at increased risk of stroke, the present study was conducted. Methods: We studied 4024 ambulatory women aged 65 years or older participating in the prospective Study of Osteoporotic Fractures. Bone mineral density was measured at baseline using single photon absorptiometry; strokes were ascertained using a computerized Medicare data base and death certificates. Results: During a mean of 1.98 years of follow-up, 83 women suffered first strokes (five fatal). Osteopenia was associated with an increased stroke risk Each SD decrease in bone mineral density at the calcaneus (0.09 g/cm2) was associated with a 1.31-fold increase in stroke (95% confidence interval, 1.03-1.65), adjusted for age, follow-up time, and several potential confounders, including diabetes, systolic blood pressure, use of alcohol, cigarettes or postmenopausal estrogens, cognitive ability, grip strength, and functional ability. The observed relation between bone density and stroke was strongest for intracerebral hemorrhages and occlusions. Conclusions: Most likely, low bone density does not cause stroke; some other process probably results in both osteopenia and cerebrovascular disease.

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KW - Bone diseases, metabolic

KW - Osteoporosis

KW - Risk factors

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