Association between cardiovascular risk profiles and the presence and extent of different types of coronary atherosclerotic plaque as detected by multidetector computed tomography

Fabian Bamberg, Nina Dannemann, Michael D. Shapiro, Sujith K. Seneviratne, Maros Ferencik, Javed Butler, Wolfgang Koenig, Khurram Nasir, Ricardo C. Cury, Ahmed Tawakol, Stephan Achenbach, Thomas J. Brady, Udo Hoffmann

    Research output: Contribution to journalArticle

    67 Scopus citations


    Objective: To assess the association between cardiovascular risk factors and extent of noncalcified- (NCAP), mixed-(MCAP), and calcified coronary atherosclerotic plaque (CAP). Methods and Results: In this cross-sectional study, we included consecutive subjects who presented with chest pain but had no history of coronary artery disease (CAD) and did not develop acute coronary syndrome. Contrast-enhanced 64-slice coronary MDCT was performed to determine the presence of NCAP, MCAP, and CAP for each coronary segment. Among 195 patients (91 women, mean age: 54.6±12.0) exclusively NCAP was detected in 11 patients (5.6%). The extent of NCAP decreased and the extent of MCAP and CAP increased with age (P=0.06, P=0.02, and P=0.13, respectively). Hyperlipidemia and family history of CAD were associated with the extent of NCAP after adjusting for other risk factors (P=0.02 and P=0.04, respectively) or for the extent of MCAP and CAP (P=0.02 and P=0.05, respectively). Conclusion: Our data suggest that only a small proportion of individuals have exclusively NCAP and indicate that the relation of NCAP and CAP changes with age. Among individual risk factors, hyperlipidemia and family history of CAD may be associated with the extent of NCAP. Larger observational trials are necessary to confirm our findings.

    Original languageEnglish (US)
    Pages (from-to)568-574
    Number of pages7
    JournalArteriosclerosis, thrombosis, and vascular biology
    Issue number3
    StatePublished - Mar 1 2008



    • Atherosclerosis
    • Imaging
    • Tomography

    ASJC Scopus subject areas

    • Cardiology and Cardiovascular Medicine

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