Association between assisted reproductive technology and advanced retinopathy of prematurity

R. V Paul Chan, Yoshihiro Yonekawa, Margaux A. Morrison, Grace Sun, Ryan K. Wong, Jeffrey M. Perlman, Michael Chiang, Thomas C. Lee, M. Elizabeth Hartnett, Margaret M. DeAngelis

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Purpose: To investigate the associations between assisted reproductive technology (ART) and severe retinopathy of prematurity (ROP) requiring treatment. Methods: Retrospective analyses of inborn preterm infants screened for severe ROP at the Weill Cornell Medical Center Neonatal Intensive Care Unit at the New York-Presbyterian Hospital by single factor logistic regression and multifactor models. Results: Of 399 ethnically diverse infants, 253 were conceived naturally and 146 by ART. Eight (3.16%) patients conceived naturally, and 11 (7.53%) with ART required laser treatment. In multifactor analyses, significant risks for severe ROP requiring treatment included both gestational age (odds ratio [OR] 0.34; 95% confidence interval [CI] 0.23-0.52; P <0.001) and ART ([OR] 4.70; [CI], 1.52-4.57; P = 0.007). Conclusions: ART is associated with severe ROP requiring treatment in this cohort. This is the first report that demonstrates a statistically significant association between ART and severe ROP requiring treatment in infants in the US.

Original languageEnglish (US)
Pages (from-to)1385-1390
Number of pages6
JournalClinical Ophthalmology
Volume4
Issue number1
DOIs
StatePublished - 2010
Externally publishedYes

Fingerprint

Retinopathy of Prematurity
Assisted Reproductive Techniques
Odds Ratio
Confidence Intervals
Therapeutics
Neonatal Intensive Care Units
Premature Infants
Gestational Age
Lasers
Logistic Models

Keywords

  • Assisted reproductive technology
  • Blindness
  • Low birth rate
  • Retinopathy of prematurity

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Chan, R. V. P., Yonekawa, Y., Morrison, M. A., Sun, G., Wong, R. K., Perlman, J. M., ... DeAngelis, M. M. (2010). Association between assisted reproductive technology and advanced retinopathy of prematurity. Clinical Ophthalmology, 4(1), 1385-1390. https://doi.org/10.2147/OPTH.S15587

Association between assisted reproductive technology and advanced retinopathy of prematurity. / Chan, R. V Paul; Yonekawa, Yoshihiro; Morrison, Margaux A.; Sun, Grace; Wong, Ryan K.; Perlman, Jeffrey M.; Chiang, Michael; Lee, Thomas C.; Hartnett, M. Elizabeth; DeAngelis, Margaret M.

In: Clinical Ophthalmology, Vol. 4, No. 1, 2010, p. 1385-1390.

Research output: Contribution to journalArticle

Chan, RVP, Yonekawa, Y, Morrison, MA, Sun, G, Wong, RK, Perlman, JM, Chiang, M, Lee, TC, Hartnett, ME & DeAngelis, MM 2010, 'Association between assisted reproductive technology and advanced retinopathy of prematurity', Clinical Ophthalmology, vol. 4, no. 1, pp. 1385-1390. https://doi.org/10.2147/OPTH.S15587
Chan, R. V Paul ; Yonekawa, Yoshihiro ; Morrison, Margaux A. ; Sun, Grace ; Wong, Ryan K. ; Perlman, Jeffrey M. ; Chiang, Michael ; Lee, Thomas C. ; Hartnett, M. Elizabeth ; DeAngelis, Margaret M. / Association between assisted reproductive technology and advanced retinopathy of prematurity. In: Clinical Ophthalmology. 2010 ; Vol. 4, No. 1. pp. 1385-1390.
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