Assignment of the Chromogranin A (Chga) Locus to Homologous Regions on Mouse Chromosome 12 and Rat Chromosome 6

Dominique Simon-Chazottes, Hongjiang Wu, Robert J. Parmer, David Rozansky, Josiane Szpirer, Goran Levan, Theodore W. Kurtz, Claude Szpirer, Jean Louis Guenet, Daniel T. O'Connor

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Chromogranin A is an acidic protein, stored and released with catecholamines, and is overexpressed in genetic hypertension. In the human genome, its locus has previously been positioned on the long arm of Chromosome 14 in the 14q32 region. As a first step toward evaluating its potential linkage with hereditary hypertension, we determined its chromosomal position in mouse and rat. Chromogranin A was present as a single-copy gene in both mouse and rat. Analysis of the allele distribution in an interspecific mouse backcross by single-strand conformation polymorphism positioned the chromogranin A locus on Chromosome 12, between Igh-C and D12Pas1. Evaluation of a rat/mouse somatic cell hybrid panel indicated that, chromogranin A is on rat Chromosome 6. In each case (mouse, rat, and human), chromogranin A is in a conserved region with nearby markers including the immunoglobulin heavy chain locus.

Original languageEnglish (US)
Pages (from-to)252-255
Number of pages4
JournalGenomics
Volume17
Issue number1
DOIs
StatePublished - Jul 1993
Externally publishedYes

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Chromogranin A
Chromosomes, Human, Pair 12
Chromosomes, Human, Pair 6
Hypertension
Chromosomes, Human, Pair 14
Immunoglobulin Heavy Chains
Hybrid Cells
Human Genome
Catecholamines
Alleles
Genes
Proteins

ASJC Scopus subject areas

  • Genetics

Cite this

Simon-Chazottes, D., Wu, H., Parmer, R. J., Rozansky, D., Szpirer, J., Levan, G., ... O'Connor, D. T. (1993). Assignment of the Chromogranin A (Chga) Locus to Homologous Regions on Mouse Chromosome 12 and Rat Chromosome 6. Genomics, 17(1), 252-255. https://doi.org/10.1006/geno.1993.1316

Assignment of the Chromogranin A (Chga) Locus to Homologous Regions on Mouse Chromosome 12 and Rat Chromosome 6. / Simon-Chazottes, Dominique; Wu, Hongjiang; Parmer, Robert J.; Rozansky, David; Szpirer, Josiane; Levan, Goran; Kurtz, Theodore W.; Szpirer, Claude; Guenet, Jean Louis; O'Connor, Daniel T.

In: Genomics, Vol. 17, No. 1, 07.1993, p. 252-255.

Research output: Contribution to journalArticle

Simon-Chazottes, D, Wu, H, Parmer, RJ, Rozansky, D, Szpirer, J, Levan, G, Kurtz, TW, Szpirer, C, Guenet, JL & O'Connor, DT 1993, 'Assignment of the Chromogranin A (Chga) Locus to Homologous Regions on Mouse Chromosome 12 and Rat Chromosome 6', Genomics, vol. 17, no. 1, pp. 252-255. https://doi.org/10.1006/geno.1993.1316
Simon-Chazottes, Dominique ; Wu, Hongjiang ; Parmer, Robert J. ; Rozansky, David ; Szpirer, Josiane ; Levan, Goran ; Kurtz, Theodore W. ; Szpirer, Claude ; Guenet, Jean Louis ; O'Connor, Daniel T. / Assignment of the Chromogranin A (Chga) Locus to Homologous Regions on Mouse Chromosome 12 and Rat Chromosome 6. In: Genomics. 1993 ; Vol. 17, No. 1. pp. 252-255.
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