Assignment of the chromogranin a (chga) locus to homologous regions on mouse chromosome 12 and rat chromosome 6

Dominique Simon-Chazottes, Hongjiang Wu, Robert J. Parmer, David J. Rozansky, Josiane Szpirer, Goran Levan, Theodore W. Kurtz, Claude Szpirer, Jean Louis Guenet, Daniel T. O'Connor

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Abstract

Chromogranin A is an acidic protein, stored and released with catecholamines, and is overexpressed in genetic hypertension. In the human genome, its locus has previously been positioned on the long arm of Chromosome 14 in the 14q32 region. As a first step toward evaluating its potential linkage with hereditary hypertension, we determined its chromosomal position in mouse and rat. Chromogranin A was present as a single-copy gene in both mouse and rat. Analysis of the allele distribution in an interspecific mouse backcross by single-strand conformation polymorphism positioned the chromogranin A locus on Chromosome 12, between Igh-C and D12Pas1. Evaluation of a rat/mouse somatic cell hybrid panel indicated that, chromogranin A is on rat Chromosome 6. In each case (mouse, rat, and human), chromogranin A is in a conserved region with nearby markers including the immunoglobulin heavy chain locus.

Original languageEnglish (US)
Pages (from-to)252-255
Number of pages4
JournalGenomics
Volume17
Issue number1
DOIs
StatePublished - Jul 1993

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ASJC Scopus subject areas

  • Genetics

Cite this

Simon-Chazottes, D., Wu, H., Parmer, R. J., Rozansky, D. J., Szpirer, J., Levan, G., Kurtz, T. W., Szpirer, C., Guenet, J. L., & O'Connor, D. T. (1993). Assignment of the chromogranin a (chga) locus to homologous regions on mouse chromosome 12 and rat chromosome 6. Genomics, 17(1), 252-255. https://doi.org/10.1006/geno.1993.1316