Assignment of Etfdh, Etfb, and Etfa to chromosomes 3, 7, and 13: The mouse homologs of genes responsible for glutaric acidemia type II in human

Robert A. White, Lisa L. Dowler, Stephen V. Angeloni, David Koeller

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Abstract

Electron transfer flavoprotein (composed of α and β subunits) is an obligatory electron acceptor for several dehydrogenases and is located in the mitochondrial matrix. Electrons accepted by electron transfer flavoprotein (ETF) are transferred to the main mitochondrial respiratory chain by way of ETF dehydrogenase (ETFDH). In humans, deficiency of ETF or ETFDH leads to glutaric acidemia type II, an inherited metabolic disorder that can be fatal in its neonatal form and is characterized by severe hypoketotic hypoglycemia and acidosis. We used cDNA probes for the Etfdh, Etfb, and Etfa genes to determine localization of these mouse genes to chromosomes 3, 7, and 13.

Original languageEnglish (US)
Pages (from-to)131-134
Number of pages4
JournalGenomics
Volume33
Issue number1
DOIs
Publication statusPublished - Apr 1 1996
Externally publishedYes

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ASJC Scopus subject areas

  • Genetics

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