Assignment of Etfdh, Etfb, and Etfa to chromosomes 3, 7, and 13: The mouse homologs of genes responsible for glutaric acidemia type II in human

Robert A. White, Lisa L. Dowler, Stephen V. Angeloni, David Koeller

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Electron transfer flavoprotein (composed of α and β subunits) is an obligatory electron acceptor for several dehydrogenases and is located in the mitochondrial matrix. Electrons accepted by electron transfer flavoprotein (ETF) are transferred to the main mitochondrial respiratory chain by way of ETF dehydrogenase (ETFDH). In humans, deficiency of ETF or ETFDH leads to glutaric acidemia type II, an inherited metabolic disorder that can be fatal in its neonatal form and is characterized by severe hypoketotic hypoglycemia and acidosis. We used cDNA probes for the Etfdh, Etfb, and Etfa genes to determine localization of these mouse genes to chromosomes 3, 7, and 13.

Original languageEnglish (US)
Pages (from-to)131-134
Number of pages4
JournalGenomics
Volume33
Issue number1
DOIs
StatePublished - Apr 1 1996
Externally publishedYes

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Multiple Acyl Coenzyme A Dehydrogenase Deficiency
Electron-Transferring Flavoproteins
Chromosomes, Human, Pair 13
Chromosomes, Human, Pair 3
Chromosomes, Human, Pair 7
Oxidoreductases
Electrons
Genes
Electron Transport
Acidosis
Hypoglycemia
Complementary DNA

ASJC Scopus subject areas

  • Genetics

Cite this

Assignment of Etfdh, Etfb, and Etfa to chromosomes 3, 7, and 13 : The mouse homologs of genes responsible for glutaric acidemia type II in human. / White, Robert A.; Dowler, Lisa L.; Angeloni, Stephen V.; Koeller, David.

In: Genomics, Vol. 33, No. 1, 01.04.1996, p. 131-134.

Research output: Contribution to journalArticle

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