Assessments of pain, functional impairment, anxiety, and depression in US adults with hemophilia across patient-reported outcome instruments in the Pain, Functional Impairment, and Quality of Life (P-FiQ) study

Tyler W. Buckner, Katharine Batt, Doris Quon, Michelle Witkop, Michael Recht, Craig Kessler, Kimberly Baumann, Grace Hernandez, Michael Wang, David L. Cooper, Christine L. Kempton

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Introduction: Pain, functional impairment, anxiety, and depression associated with joint disease may affect health-related quality of life (HRQoL) in people with hemophilia. Objective: To report detailed patient-reported outcomes (PRO) assessments related to HRQoL in participants in the Pain, Functional Impairment, and Quality of Life (P-FiQ) study. Methods: Pain and HRQoL were assessed via PRO instruments in US adult males with hemophilia A or B and a history of joint pain or bleeding. PRO instruments included EQ-5D-5L with visual analog scale, Brief Pain Inventory v2 Short Form, SF-36v2, and Hemophilia Activities List. Instrument domain and item responses were described. Results: Responses were collected from 381 adult males with a median age of 34 years. Pain was observed across instruments and affected daily activities and quality of life. Respondents reported functional impairment that limited the kind of work and activities they participated in, with activities involving the lower extremities being most affected. A high prevalence of mental health disorders was identified across instruments. Conclusions: Pain and HRQoL were evaluated using multiple PRO instruments, which vary in timescales of assessment and levels of detail. More consistent clinical assessments and patient dialog regarding pain and aspects of HRQoL may help drive improved outcomes.

Original languageEnglish (US)
Pages (from-to)5-13
Number of pages9
JournalEuropean Journal of Haematology
Volume100
DOIs
StatePublished - Apr 1 2018

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Hemophilia A
Pain Measurement
Anxiety
Quality of Life
Depression
Pain
Patient Outcome Assessment
Hemophilia B
Joint Diseases
Arthralgia
Patient Reported Outcome Measures
Mental Disorders
Lower Extremity
Mental Health
Hemorrhage
Equipment and Supplies

Keywords

  • coagulation disorders
  • quality of life

ASJC Scopus subject areas

  • Hematology

Cite this

Assessments of pain, functional impairment, anxiety, and depression in US adults with hemophilia across patient-reported outcome instruments in the Pain, Functional Impairment, and Quality of Life (P-FiQ) study. / Buckner, Tyler W.; Batt, Katharine; Quon, Doris; Witkop, Michelle; Recht, Michael; Kessler, Craig; Baumann, Kimberly; Hernandez, Grace; Wang, Michael; Cooper, David L.; Kempton, Christine L.

In: European Journal of Haematology, Vol. 100, 01.04.2018, p. 5-13.

Research output: Contribution to journalArticle

Buckner, Tyler W. ; Batt, Katharine ; Quon, Doris ; Witkop, Michelle ; Recht, Michael ; Kessler, Craig ; Baumann, Kimberly ; Hernandez, Grace ; Wang, Michael ; Cooper, David L. ; Kempton, Christine L. / Assessments of pain, functional impairment, anxiety, and depression in US adults with hemophilia across patient-reported outcome instruments in the Pain, Functional Impairment, and Quality of Life (P-FiQ) study. In: European Journal of Haematology. 2018 ; Vol. 100. pp. 5-13.
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abstract = "Introduction: Pain, functional impairment, anxiety, and depression associated with joint disease may affect health-related quality of life (HRQoL) in people with hemophilia. Objective: To report detailed patient-reported outcomes (PRO) assessments related to HRQoL in participants in the Pain, Functional Impairment, and Quality of Life (P-FiQ) study. Methods: Pain and HRQoL were assessed via PRO instruments in US adult males with hemophilia A or B and a history of joint pain or bleeding. PRO instruments included EQ-5D-5L with visual analog scale, Brief Pain Inventory v2 Short Form, SF-36v2, and Hemophilia Activities List. Instrument domain and item responses were described. Results: Responses were collected from 381 adult males with a median age of 34 years. Pain was observed across instruments and affected daily activities and quality of life. Respondents reported functional impairment that limited the kind of work and activities they participated in, with activities involving the lower extremities being most affected. A high prevalence of mental health disorders was identified across instruments. Conclusions: Pain and HRQoL were evaluated using multiple PRO instruments, which vary in timescales of assessment and levels of detail. More consistent clinical assessments and patient dialog regarding pain and aspects of HRQoL may help drive improved outcomes.",
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AU - Batt, Katharine

AU - Quon, Doris

AU - Witkop, Michelle

AU - Recht, Michael

AU - Kessler, Craig

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AU - Hernandez, Grace

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