Assessment of risk area during coronary occlusion and infarct size after reperfusion with myocardial contrast echocardiography using left and right atrial injections of contrast

Flordeliza S. Villanueva, William P. Glasheen, Jiri Sklenar, Sanjiv Kaul

Research output: Contribution to journalArticle

111 Citations (Scopus)

Abstract

Background. Myocardial opaciflcation during echocardiography has been demonstrated after left (LA) and right (RA) atrial injections of contrast, and microvascular damage with reduced blood flow and impaired flow reserve has been documented in necrotic myocardial tissue. Therefore, we hypothesized that because of its ability to depict capillary perfusion, myocardial contrast echocardiography (MCE) can be used to define risk area during coronary occlusion and infarct size after reperfusion with LA and RA injections of contrast in the presence of pharmacologically induced coronary hyperemia. Methods and Results. Eighteen open-chest anesthetized dogs with 3 to 6 hours of left anterior descending artery occlusion and 15 minutes of reflow were studied in the presence of either dipyridamole (0.56 mg/kg over a period of 4 minutes) or dobutamine (15 μg · kg-1 · min-1). Technetium autoradiography was performed for risk area assessment; infarct size was measured with triphenyl tetrazolium7 chloride; and in 11 dogs, myocardial blood flow was measured with radiolabeled microspheres. A close linear relation was noted between the MCE defect size and autoradiographic risk area during coronary occlusion both during LA (y=0.95x-0.25, r=.97, P

Original languageEnglish (US)
Pages (from-to)596-604
Number of pages9
JournalCirculation
Volume88
Issue number2
StatePublished - Aug 1993
Externally publishedYes

Fingerprint

Myocardial Reperfusion
Coronary Occlusion
Echocardiography
Injections
Dogs
Dobutamine
Dipyridamole
Technetium
Hyperemia
Autoradiography
Microspheres
Reperfusion
Chlorides
Thorax
Arteries
Perfusion

Keywords

  • Echocardiography
  • Infarcts
  • Occlusion
  • Reperfusion

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Assessment of risk area during coronary occlusion and infarct size after reperfusion with myocardial contrast echocardiography using left and right atrial injections of contrast. / Villanueva, Flordeliza S.; Glasheen, William P.; Sklenar, Jiri; Kaul, Sanjiv.

In: Circulation, Vol. 88, No. 2, 08.1993, p. 596-604.

Research output: Contribution to journalArticle

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AU - Glasheen, William P.

AU - Sklenar, Jiri

AU - Kaul, Sanjiv

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AB - Background. Myocardial opaciflcation during echocardiography has been demonstrated after left (LA) and right (RA) atrial injections of contrast, and microvascular damage with reduced blood flow and impaired flow reserve has been documented in necrotic myocardial tissue. Therefore, we hypothesized that because of its ability to depict capillary perfusion, myocardial contrast echocardiography (MCE) can be used to define risk area during coronary occlusion and infarct size after reperfusion with LA and RA injections of contrast in the presence of pharmacologically induced coronary hyperemia. Methods and Results. Eighteen open-chest anesthetized dogs with 3 to 6 hours of left anterior descending artery occlusion and 15 minutes of reflow were studied in the presence of either dipyridamole (0.56 mg/kg over a period of 4 minutes) or dobutamine (15 μg · kg-1 · min-1). Technetium autoradiography was performed for risk area assessment; infarct size was measured with triphenyl tetrazolium7 chloride; and in 11 dogs, myocardial blood flow was measured with radiolabeled microspheres. A close linear relation was noted between the MCE defect size and autoradiographic risk area during coronary occlusion both during LA (y=0.95x-0.25, r=.97, P

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