Assessment of progestin-only therapy for endometriosis in macaque

Gwen Maginnis, J. Wilk, R. Carroll, Ov Slayden

    Research output: Contribution to journalArticle

    9 Citations (Scopus)

    Abstract

    Background: Endometriosis is a condition where endometrium-like tissue forms lesions at ectopic sites outside the uterus. In women, oral contraceptive pills and progestins are often prescribed as therapy for early stage endometriosis. In contrast, in macaques the disease is frequently advanced at the time of diagnosis and ovariectomy is the standard therapy. However, surgery is contraindicated in many patients. A review of 15 endometriosis cases over the past 10 years at the Oregon National Primate Research Center (ONPRC) revealed that 5 failed to show improvement after ovariectomy and were subsequently euthanized. Therefore, our goal was to assess the feasibility of treating endometriosis in macaques with chronic progesterone (P) as an alternative therapy for the disease. Methods: Seven adult rhesus macaques with advanced endometriosis were identified by clinical symptoms and endometriosis was confirmed by abdominal palpation, ultrasound examination, and/or aspiration of menstrual blood from abdominal cysts. The patients were chronically treated with Silastic capsules that released 5-7 ng P/ml in blood for up to 20 months. During treatment the patients were assessed daily and scored numerically for appetite, activity, attitude, abdominal discomfort and menstruation by the Clinical Veterinary staff. The patients were then re-examined by abdominal palpation and ultrasound for the disease at the end of treatment. Results: During the first 2 weeks of treatment, endometriotic symptoms improved significantly in all the patients (P <0.05). This was associated with a significant increase in body weight and significant reduction in abdominal discomfort and menstrual bleeding. Two of the patients gradually developed increased symptoms of the disease after 5months of treatment. Post-treatment abdominal examination revealed that 2/5 patients continued to have an abdominal mass even though symptoms were suppressed. Conclusions: We conclude that continuous P treatment of rhesus monkeys provides therapeutic benefit to reduce symptoms of endometriosis and may provide an option for cases where ovariectomy is contraindicated. Supported by RR-00163.

    Original languageEnglish (US)
    Pages (from-to)52-55
    Number of pages4
    JournalJournal of Medical Primatology
    Volume37
    Issue numberSUPPL.1
    DOIs
    StatePublished - Feb 2008

    Fingerprint

    progestational hormones
    Macaca
    Progestins
    Endometriosis
    signs and symptoms (animals and humans)
    therapeutics
    ovariectomy
    Ovariectomy
    Macaca mulatta
    Therapeutics
    Palpation
    oral contraceptives
    menstruation
    alternative medicine
    endometrium
    blood
    appetite
    lesions (animal)
    uterus
    Menstruation

    Keywords

    • Endometriosis
    • Progesterone
    • Progestin
    • Rhesus macaque

    ASJC Scopus subject areas

    • Animal Science and Zoology
    • veterinary(all)

    Cite this

    Assessment of progestin-only therapy for endometriosis in macaque. / Maginnis, Gwen; Wilk, J.; Carroll, R.; Slayden, Ov.

    In: Journal of Medical Primatology, Vol. 37, No. SUPPL.1, 02.2008, p. 52-55.

    Research output: Contribution to journalArticle

    Maginnis, Gwen ; Wilk, J. ; Carroll, R. ; Slayden, Ov. / Assessment of progestin-only therapy for endometriosis in macaque. In: Journal of Medical Primatology. 2008 ; Vol. 37, No. SUPPL.1. pp. 52-55.
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