Assessment of moderate coffee consumption and risk of epithelial ovarian cancer: A Mendelian randomization study

Ovarian Cancer Association Consortium

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Coffee consumption has been shown to be associated with various health outcomes in observational studies. However, evidence for its association with epithelial ovarian cancer (EOC) is inconsistent and it is unclear whether these associations are causal. Methods: We used single nucleotide polymorphisms associated with (i) coffee and (ii) caffeine consumption to perform Mendelian randomization (MR) on EOC risk. We conducted a two-sample MR using genetic data on 44 062 individuals of European ancestry from the Ovarian Cancer Association Consortium (OCAC), and combined instrumental variable estimates using aWald-type ratio estimator. Results: For all EOC cases, the causal odds ratio (COR) for genetically predicted consumption of one additional cup of coffee per day was 0.92 [95% confidence interval (CI): 0.79, 1.06]. The COR was 0.90 (95% CI: 0.73, 1.10) for high-grade serous EOC. The COR for genetically predicted consumption of an additional 80mg caffeine was 1.01 (95% CI: 0.92, 1.11) for all EOC cases and 0.90 (95% CI: 0.73, 1.10) for high-grade serous cases. Conclusions: We found no evidence indicative of a strong association between EOC risk and genetically predicted coffee or caffeine levels. However, our estimates were not statistically inconsistent with earlier observational studies and we were unable to rule out small protective associations.

Original languageEnglish (US)
Pages (from-to)450-459
Number of pages10
JournalInternational Journal of Epidemiology
Volume47
Issue number2
DOIs
StatePublished - Apr 1 2018

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Coffee
Random Allocation
Caffeine
Confidence Intervals
Odds Ratio
Observational Studies
Ovarian Neoplasms
Single Nucleotide Polymorphism
Ovarian epithelial cancer
Health

Keywords

  • Caffeine
  • Causality
  • Coffee
  • Mendelian randomization
  • Ovarian cancer

ASJC Scopus subject areas

  • Epidemiology

Cite this

Assessment of moderate coffee consumption and risk of epithelial ovarian cancer : A Mendelian randomization study. / Ovarian Cancer Association Consortium.

In: International Journal of Epidemiology, Vol. 47, No. 2, 01.04.2018, p. 450-459.

Research output: Contribution to journalArticle

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title = "Assessment of moderate coffee consumption and risk of epithelial ovarian cancer: A Mendelian randomization study",
abstract = "Background: Coffee consumption has been shown to be associated with various health outcomes in observational studies. However, evidence for its association with epithelial ovarian cancer (EOC) is inconsistent and it is unclear whether these associations are causal. Methods: We used single nucleotide polymorphisms associated with (i) coffee and (ii) caffeine consumption to perform Mendelian randomization (MR) on EOC risk. We conducted a two-sample MR using genetic data on 44 062 individuals of European ancestry from the Ovarian Cancer Association Consortium (OCAC), and combined instrumental variable estimates using aWald-type ratio estimator. Results: For all EOC cases, the causal odds ratio (COR) for genetically predicted consumption of one additional cup of coffee per day was 0.92 [95{\%} confidence interval (CI): 0.79, 1.06]. The COR was 0.90 (95{\%} CI: 0.73, 1.10) for high-grade serous EOC. The COR for genetically predicted consumption of an additional 80mg caffeine was 1.01 (95{\%} CI: 0.92, 1.11) for all EOC cases and 0.90 (95{\%} CI: 0.73, 1.10) for high-grade serous cases. Conclusions: We found no evidence indicative of a strong association between EOC risk and genetically predicted coffee or caffeine levels. However, our estimates were not statistically inconsistent with earlier observational studies and we were unable to rule out small protective associations.",
keywords = "Caffeine, Causality, Coffee, Mendelian randomization, Ovarian cancer",
author = "{Ovarian Cancer Association Consortium} and Ong, {Jue Sheng} and Hwang, {Liang Dar} and Gabriel Cuellar-Partida and Martin, {Nicholas G.} and Georgia Chenevix-Trench and Quinn, {Michael C.J.} and Cornelis, {Marilyn C.} and Puya Gharahkhani and Penelope MWebb and Stuart MacGregor and Enda Bryne and Fasching, {Peter A.} and Alexander Hein and Stefanie Burghaus and Beckmann, {Matthias W.} and Diether Lambrechts and {Van Nieuwenhuysen}, Els and Ignace Vergote and Adriaan Vanderstichele and Swerdlow, {Anthony J.} and Michael Jones and Nicholas Orr and Minouk Schoemaker and Edwards, {Digna Velez} and James Brenton and Javier Ben{\'i}tez and Garc{\'i}a, {Mar{\'i}a J.} and Rodriguez-Antona, {Cristina R.} and Rossing, {Mary Anne} and Fortner, {Ren{\'e}e T.} and Elio Riboli and Jenny Chang-Claude and Ursula Eilber and Shan Wang-Gohrke and Drakoulis Yannoukakos and Goodman, {Marc T.} and Natalia Bogdanova and Thilo D{\"o}rk and Matthias Duerst and Peter Hillemanns and Runnebaum, {Ingo B.} and Natalia Antonenkova and Ralf Butzow and Heli Nevanlinna and Pelttari, {Liisa M.} and Edwards, {Robert P.} and Kelley, {Joseph L.} and Francesmary Modugno and Moysich, {Kirsten B.} and Tanja Pejovic",
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T1 - Assessment of moderate coffee consumption and risk of epithelial ovarian cancer

T2 - A Mendelian randomization study

AU - Ovarian Cancer Association Consortium

AU - Ong, Jue Sheng

AU - Hwang, Liang Dar

AU - Cuellar-Partida, Gabriel

AU - Martin, Nicholas G.

AU - Chenevix-Trench, Georgia

AU - Quinn, Michael C.J.

AU - Cornelis, Marilyn C.

AU - Gharahkhani, Puya

AU - MWebb, Penelope

AU - MacGregor, Stuart

AU - Bryne, Enda

AU - Fasching, Peter A.

AU - Hein, Alexander

AU - Burghaus, Stefanie

AU - Beckmann, Matthias W.

AU - Lambrechts, Diether

AU - Van Nieuwenhuysen, Els

AU - Vergote, Ignace

AU - Vanderstichele, Adriaan

AU - Swerdlow, Anthony J.

AU - Jones, Michael

AU - Orr, Nicholas

AU - Schoemaker, Minouk

AU - Edwards, Digna Velez

AU - Brenton, James

AU - Benítez, Javier

AU - García, María J.

AU - Rodriguez-Antona, Cristina R.

AU - Rossing, Mary Anne

AU - Fortner, Renée T.

AU - Riboli, Elio

AU - Chang-Claude, Jenny

AU - Eilber, Ursula

AU - Wang-Gohrke, Shan

AU - Yannoukakos, Drakoulis

AU - Goodman, Marc T.

AU - Bogdanova, Natalia

AU - Dörk, Thilo

AU - Duerst, Matthias

AU - Hillemanns, Peter

AU - Runnebaum, Ingo B.

AU - Antonenkova, Natalia

AU - Butzow, Ralf

AU - Nevanlinna, Heli

AU - Pelttari, Liisa M.

AU - Edwards, Robert P.

AU - Kelley, Joseph L.

AU - Modugno, Francesmary

AU - Moysich, Kirsten B.

AU - Pejovic, Tanja

PY - 2018/4/1

Y1 - 2018/4/1

N2 - Background: Coffee consumption has been shown to be associated with various health outcomes in observational studies. However, evidence for its association with epithelial ovarian cancer (EOC) is inconsistent and it is unclear whether these associations are causal. Methods: We used single nucleotide polymorphisms associated with (i) coffee and (ii) caffeine consumption to perform Mendelian randomization (MR) on EOC risk. We conducted a two-sample MR using genetic data on 44 062 individuals of European ancestry from the Ovarian Cancer Association Consortium (OCAC), and combined instrumental variable estimates using aWald-type ratio estimator. Results: For all EOC cases, the causal odds ratio (COR) for genetically predicted consumption of one additional cup of coffee per day was 0.92 [95% confidence interval (CI): 0.79, 1.06]. The COR was 0.90 (95% CI: 0.73, 1.10) for high-grade serous EOC. The COR for genetically predicted consumption of an additional 80mg caffeine was 1.01 (95% CI: 0.92, 1.11) for all EOC cases and 0.90 (95% CI: 0.73, 1.10) for high-grade serous cases. Conclusions: We found no evidence indicative of a strong association between EOC risk and genetically predicted coffee or caffeine levels. However, our estimates were not statistically inconsistent with earlier observational studies and we were unable to rule out small protective associations.

AB - Background: Coffee consumption has been shown to be associated with various health outcomes in observational studies. However, evidence for its association with epithelial ovarian cancer (EOC) is inconsistent and it is unclear whether these associations are causal. Methods: We used single nucleotide polymorphisms associated with (i) coffee and (ii) caffeine consumption to perform Mendelian randomization (MR) on EOC risk. We conducted a two-sample MR using genetic data on 44 062 individuals of European ancestry from the Ovarian Cancer Association Consortium (OCAC), and combined instrumental variable estimates using aWald-type ratio estimator. Results: For all EOC cases, the causal odds ratio (COR) for genetically predicted consumption of one additional cup of coffee per day was 0.92 [95% confidence interval (CI): 0.79, 1.06]. The COR was 0.90 (95% CI: 0.73, 1.10) for high-grade serous EOC. The COR for genetically predicted consumption of an additional 80mg caffeine was 1.01 (95% CI: 0.92, 1.11) for all EOC cases and 0.90 (95% CI: 0.73, 1.10) for high-grade serous cases. Conclusions: We found no evidence indicative of a strong association between EOC risk and genetically predicted coffee or caffeine levels. However, our estimates were not statistically inconsistent with earlier observational studies and we were unable to rule out small protective associations.

KW - Caffeine

KW - Causality

KW - Coffee

KW - Mendelian randomization

KW - Ovarian cancer

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U2 - 10.1093/IJE/DYX236

DO - 10.1093/IJE/DYX236

M3 - Article

C2 - 29186515

AN - SCOPUS:85048363842

VL - 47

SP - 450

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JO - International Journal of Epidemiology

JF - International Journal of Epidemiology

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