Assessment of interventricular dyssynchrony by real time three-dimensional echocardiography

An in vitro study in a porcine model

Minjuan Zheng, Xiaokui Li, Pengyuan Zhang, Weihui Shentu, Muhammad Ashraf, Galym Imanbayev, Cole Streiff, Shuping Ge, David Sahn

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Loss of synchronous contraction between or within the right and left ventricle (RV, LV) leads to adverse ventricular function. We used real time three-dimensional echocardiography (RT3DE) for evaluation of severity of interventricular dyssynchrony and function in a porcine heart model. Methods: Six fresh in vitro porcine hearts were used to create a controlled model of LV and RV dyssynchrony using two sets of pulsatile pumps. Synchronized and dyssynchronized pump settings were used with two different dyssynchronized settings: LV filled first and RV filled first. Results: There was good correlation between actual measurement and RT3DE for interventricular time difference (r = 0.95, P <0.0001) and stroke volume (SV) for LV and RV (0.89, 0.85; P <0.0001, respectively). RT3DE data showed a small but significant underestimation for actual volume (P <0.05). The intra- and interobserver variabilities are 2.9 ± 1.5% and 3.1 ± 5.4% for LV and RV SVs, and 1.7 ± 2.4% and 2.2 ± 3.2% for time differences by RT3DE. There was significant difference in RV SV between synchrony and dyssynchrony when the RV filled first (P <0.05), but not in other groups. The same pattern was found in RT3DE derived SVs (synchrony versus dyssynchrony with RV filled first, P <0.05). Conclusions: There is no compromise in LV SV during interventricular dyssynchrony; but RV SV was significantly diminished when the RV filled first. RT3DE is a feasible, robust and reproducible method to identify interventricular dyssynchrony and to evaluate ventricular SVs.

Original languageEnglish (US)
Pages (from-to)709-715
Number of pages7
JournalEchocardiography
Volume27
Issue number6
DOIs
StatePublished - Jul 2010

Fingerprint

Three-Dimensional Echocardiography
Stroke Volume
Swine
Heart Ventricles
Observer Variation
Ventricular Function
In Vitro Techniques

Keywords

  • left ventricular function
  • right ventricular function
  • three-dimensional echocardiography

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

Assessment of interventricular dyssynchrony by real time three-dimensional echocardiography : An in vitro study in a porcine model. / Zheng, Minjuan; Li, Xiaokui; Zhang, Pengyuan; Shentu, Weihui; Ashraf, Muhammad; Imanbayev, Galym; Streiff, Cole; Ge, Shuping; Sahn, David.

In: Echocardiography, Vol. 27, No. 6, 07.2010, p. 709-715.

Research output: Contribution to journalArticle

Zheng, M, Li, X, Zhang, P, Shentu, W, Ashraf, M, Imanbayev, G, Streiff, C, Ge, S & Sahn, D 2010, 'Assessment of interventricular dyssynchrony by real time three-dimensional echocardiography: An in vitro study in a porcine model', Echocardiography, vol. 27, no. 6, pp. 709-715. https://doi.org/10.1111/j.1540-8175.2009.01094.x
Zheng, Minjuan ; Li, Xiaokui ; Zhang, Pengyuan ; Shentu, Weihui ; Ashraf, Muhammad ; Imanbayev, Galym ; Streiff, Cole ; Ge, Shuping ; Sahn, David. / Assessment of interventricular dyssynchrony by real time three-dimensional echocardiography : An in vitro study in a porcine model. In: Echocardiography. 2010 ; Vol. 27, No. 6. pp. 709-715.
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abstract = "Background: Loss of synchronous contraction between or within the right and left ventricle (RV, LV) leads to adverse ventricular function. We used real time three-dimensional echocardiography (RT3DE) for evaluation of severity of interventricular dyssynchrony and function in a porcine heart model. Methods: Six fresh in vitro porcine hearts were used to create a controlled model of LV and RV dyssynchrony using two sets of pulsatile pumps. Synchronized and dyssynchronized pump settings were used with two different dyssynchronized settings: LV filled first and RV filled first. Results: There was good correlation between actual measurement and RT3DE for interventricular time difference (r = 0.95, P <0.0001) and stroke volume (SV) for LV and RV (0.89, 0.85; P <0.0001, respectively). RT3DE data showed a small but significant underestimation for actual volume (P <0.05). The intra- and interobserver variabilities are 2.9 ± 1.5{\%} and 3.1 ± 5.4{\%} for LV and RV SVs, and 1.7 ± 2.4{\%} and 2.2 ± 3.2{\%} for time differences by RT3DE. There was significant difference in RV SV between synchrony and dyssynchrony when the RV filled first (P <0.05), but not in other groups. The same pattern was found in RT3DE derived SVs (synchrony versus dyssynchrony with RV filled first, P <0.05). Conclusions: There is no compromise in LV SV during interventricular dyssynchrony; but RV SV was significantly diminished when the RV filled first. RT3DE is a feasible, robust and reproducible method to identify interventricular dyssynchrony and to evaluate ventricular SVs.",
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AU - Zheng, Minjuan

AU - Li, Xiaokui

AU - Zhang, Pengyuan

AU - Shentu, Weihui

AU - Ashraf, Muhammad

AU - Imanbayev, Galym

AU - Streiff, Cole

AU - Ge, Shuping

AU - Sahn, David

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N2 - Background: Loss of synchronous contraction between or within the right and left ventricle (RV, LV) leads to adverse ventricular function. We used real time three-dimensional echocardiography (RT3DE) for evaluation of severity of interventricular dyssynchrony and function in a porcine heart model. Methods: Six fresh in vitro porcine hearts were used to create a controlled model of LV and RV dyssynchrony using two sets of pulsatile pumps. Synchronized and dyssynchronized pump settings were used with two different dyssynchronized settings: LV filled first and RV filled first. Results: There was good correlation between actual measurement and RT3DE for interventricular time difference (r = 0.95, P <0.0001) and stroke volume (SV) for LV and RV (0.89, 0.85; P <0.0001, respectively). RT3DE data showed a small but significant underestimation for actual volume (P <0.05). The intra- and interobserver variabilities are 2.9 ± 1.5% and 3.1 ± 5.4% for LV and RV SVs, and 1.7 ± 2.4% and 2.2 ± 3.2% for time differences by RT3DE. There was significant difference in RV SV between synchrony and dyssynchrony when the RV filled first (P <0.05), but not in other groups. The same pattern was found in RT3DE derived SVs (synchrony versus dyssynchrony with RV filled first, P <0.05). Conclusions: There is no compromise in LV SV during interventricular dyssynchrony; but RV SV was significantly diminished when the RV filled first. RT3DE is a feasible, robust and reproducible method to identify interventricular dyssynchrony and to evaluate ventricular SVs.

AB - Background: Loss of synchronous contraction between or within the right and left ventricle (RV, LV) leads to adverse ventricular function. We used real time three-dimensional echocardiography (RT3DE) for evaluation of severity of interventricular dyssynchrony and function in a porcine heart model. Methods: Six fresh in vitro porcine hearts were used to create a controlled model of LV and RV dyssynchrony using two sets of pulsatile pumps. Synchronized and dyssynchronized pump settings were used with two different dyssynchronized settings: LV filled first and RV filled first. Results: There was good correlation between actual measurement and RT3DE for interventricular time difference (r = 0.95, P <0.0001) and stroke volume (SV) for LV and RV (0.89, 0.85; P <0.0001, respectively). RT3DE data showed a small but significant underestimation for actual volume (P <0.05). The intra- and interobserver variabilities are 2.9 ± 1.5% and 3.1 ± 5.4% for LV and RV SVs, and 1.7 ± 2.4% and 2.2 ± 3.2% for time differences by RT3DE. There was significant difference in RV SV between synchrony and dyssynchrony when the RV filled first (P <0.05), but not in other groups. The same pattern was found in RT3DE derived SVs (synchrony versus dyssynchrony with RV filled first, P <0.05). Conclusions: There is no compromise in LV SV during interventricular dyssynchrony; but RV SV was significantly diminished when the RV filled first. RT3DE is a feasible, robust and reproducible method to identify interventricular dyssynchrony and to evaluate ventricular SVs.

KW - left ventricular function

KW - right ventricular function

KW - three-dimensional echocardiography

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