Assessment of hepatocellular carcinoma vascularity before and after transcatheter arterial chemoembolization by using first pass perfusion weighted MR imaging

Jun Gong Zhao, Gan Sheng Feng, Xiang Quan Kong, Xin Li, Ming Hua Li, Ying Sheng Cheng

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17 Scopus citations

Abstract

Aim: To assess the vascularity of hepatocellular carcinoma (HCC) before and after transcatheter arterial chemoembolization (TACE) with the quantitative parameters obtained by first pass perfusion weighted MR imaging (FP-MRI). Methods: Seventeen consecutive patients with one to three lesions in liver underwent FP-MRI before treatment. FP-MRI was also performed one, three, six, nine months, and one year after TACE. The baseline signal intensity (S0) of pre-TACE and one month after TACE was analyzed, the vascularity of HCC assessed by steepest slope of the signal intensity versus time curves (SS) was blindly correlated with their DSA feature and clinical outcome. Results: No significant difference was found on baseline signal intensity (SO) between pre-TACE and one month after TACE (F=0.309, P=0.583), The SS (mean, 32% per second) of lesion one month after TACE was lower than that of pre-TACE (mean, 69% per second), but with no statistical significance (F=3.067, P=0.092). When local recurrence occurred, the time intensity curves became steeper. The vascularity of HCC before and after TACE graded by SS closely correlated with that by DSA (K=0.453, P<0.05). Conclusion: FP-MRI is a useful criterion for selecting effective interventional treatment for patients with HCC in their initial treatment and during follow up.

Original languageEnglish (US)
Pages (from-to)1152-1156
Number of pages5
JournalWorld Journal of Gastroenterology
Volume10
Issue number8
Publication statusPublished - Apr 15 2004
Externally publishedYes

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ASJC Scopus subject areas

  • Gastroenterology

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