Assessment of direct effects of dobutamine on coronary microcirculation with myocardial contrast echocardiography

comparison with adenosine

Jian ping Bin, Dai-Trang (Elizabeth) Le, Fan Yang, Dao gang Zha, Yi li Liu, Sanjiv Kaul

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: To evaluate the direct effects of dobutamine as compared to adenosine on the coronary microcirculation in both normal and stenotic segments using myocardial contrast echocardiography (MCE). METHODS: Left anterior descending (LAD) coronary artery stenosis, which was not flow limiting at rest, was established in 9 dogs. At the baseline and during intracoronary infusion of dobutamine (2 mg.kg(-1).min(-1)) and adenosine (5 mg.kg(-1).min(-1)), the radiolabeled microsphere (RM)-derived myocardial blood flow (MBF) were determined, and the double product (DP) and myocardial vascular resistance (MVR) were calculated. MCE was performed to determine the myocardial blood volume (MBV, represented by A) and microbubble velocity (beta). RESULTS: As compared to the baseline level, the MBF increased and MVR decreased significantly in both the normal and abnormal beds during infusion of both drugs (P

Original languageEnglish (US)
Pages (from-to)348-352
Number of pages5
JournalNan fang yi ke da xue xue bao = Journal of Southern Medical University
Volume28
Issue number3
StatePublished - Mar 2008
Externally publishedYes

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Dobutamine
Microcirculation
Vascular Resistance
Adenosine
Echocardiography
Microbubbles
Coronary Stenosis
Blood Volume
Microspheres
Dogs
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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title = "Assessment of direct effects of dobutamine on coronary microcirculation with myocardial contrast echocardiography: comparison with adenosine",
abstract = "OBJECTIVE: To evaluate the direct effects of dobutamine as compared to adenosine on the coronary microcirculation in both normal and stenotic segments using myocardial contrast echocardiography (MCE). METHODS: Left anterior descending (LAD) coronary artery stenosis, which was not flow limiting at rest, was established in 9 dogs. At the baseline and during intracoronary infusion of dobutamine (2 mg.kg(-1).min(-1)) and adenosine (5 mg.kg(-1).min(-1)), the radiolabeled microsphere (RM)-derived myocardial blood flow (MBF) were determined, and the double product (DP) and myocardial vascular resistance (MVR) were calculated. MCE was performed to determine the myocardial blood volume (MBV, represented by A) and microbubble velocity (beta). RESULTS: As compared to the baseline level, the MBF increased and MVR decreased significantly in both the normal and abnormal beds during infusion of both drugs (P",
author = "Bin, {Jian ping} and Le, {Dai-Trang (Elizabeth)} and Fan Yang and Zha, {Dao gang} and Liu, {Yi li} and Sanjiv Kaul",
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TY - JOUR

T1 - Assessment of direct effects of dobutamine on coronary microcirculation with myocardial contrast echocardiography

T2 - comparison with adenosine

AU - Bin, Jian ping

AU - Le, Dai-Trang (Elizabeth)

AU - Yang, Fan

AU - Zha, Dao gang

AU - Liu, Yi li

AU - Kaul, Sanjiv

PY - 2008/3

Y1 - 2008/3

N2 - OBJECTIVE: To evaluate the direct effects of dobutamine as compared to adenosine on the coronary microcirculation in both normal and stenotic segments using myocardial contrast echocardiography (MCE). METHODS: Left anterior descending (LAD) coronary artery stenosis, which was not flow limiting at rest, was established in 9 dogs. At the baseline and during intracoronary infusion of dobutamine (2 mg.kg(-1).min(-1)) and adenosine (5 mg.kg(-1).min(-1)), the radiolabeled microsphere (RM)-derived myocardial blood flow (MBF) were determined, and the double product (DP) and myocardial vascular resistance (MVR) were calculated. MCE was performed to determine the myocardial blood volume (MBV, represented by A) and microbubble velocity (beta). RESULTS: As compared to the baseline level, the MBF increased and MVR decreased significantly in both the normal and abnormal beds during infusion of both drugs (P

AB - OBJECTIVE: To evaluate the direct effects of dobutamine as compared to adenosine on the coronary microcirculation in both normal and stenotic segments using myocardial contrast echocardiography (MCE). METHODS: Left anterior descending (LAD) coronary artery stenosis, which was not flow limiting at rest, was established in 9 dogs. At the baseline and during intracoronary infusion of dobutamine (2 mg.kg(-1).min(-1)) and adenosine (5 mg.kg(-1).min(-1)), the radiolabeled microsphere (RM)-derived myocardial blood flow (MBF) were determined, and the double product (DP) and myocardial vascular resistance (MVR) were calculated. MCE was performed to determine the myocardial blood volume (MBV, represented by A) and microbubble velocity (beta). RESULTS: As compared to the baseline level, the MBF increased and MVR decreased significantly in both the normal and abnormal beds during infusion of both drugs (P

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