TY - JOUR
T1 - Assessment of delayed graft function using susceptibility-weighted imaging in the early period after kidney transplantation
T2 - a feasibility study
AU - Sun, Jun
AU - Yu, Shengnan
AU - Chen, Jie
AU - Xing, Zhaoyu
AU - Zha, Tingting
AU - Fan, Min
AU - Zeng, Dexing
AU - Xing, Wei
N1 - Publisher Copyright:
© 2018, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2019/1/15
Y1 - 2019/1/15
N2 - Purpose: This study aimed to explore the feasibility of susceptibility-weighted imaging (SWI) for evaluating delayed graft function (DGF) during the early posttransplantation period. Methods: Sixty-nine recipients who accepted allograft renal transplantation underwent SWI during the second posttransplantation week. Renal allograft function was estimated via the glomerular filtration rate. Recipients with and without DGF were identified. For each transplanted kidney, the presence of abnormal signal intensity lesions (ASILs), excluding benign lesions, on SWI was assessed. Renal allograft function was compared between the recipients with and without ASILs. The correlation between ASILs and renal allograft function was tested by Spearman’s rank correlation analysis. Results: Thirty-four recipients were diagnosed with DGF, while 35 recipients showed no DGF. In the DGF group, 16 recipients had low-intensity ASILs, primarily at the corticomedullary junction of transplanted kidneys on SWI, and no ASILs were found in 18 recipients. In the non-DGF group, none of the recipients showed ASILs on SWI. In the DGF group, the renal allograft function among the 16 recipients with low-intensity ASILs was significantly lower than that among the other 18 recipients (8.5 ± 4.2 vs. 19.7 ± 9.7 mL/min, P < 0.001). The presence of low-intensity ASILs on SWI showed a moderate negative correlation with renal allograft function in recipients with DGF (r = − 0.553, P = 0.001). Conclusion: SWI can be used to evaluate DGF in the early post-kidney transplantation period.
AB - Purpose: This study aimed to explore the feasibility of susceptibility-weighted imaging (SWI) for evaluating delayed graft function (DGF) during the early posttransplantation period. Methods: Sixty-nine recipients who accepted allograft renal transplantation underwent SWI during the second posttransplantation week. Renal allograft function was estimated via the glomerular filtration rate. Recipients with and without DGF were identified. For each transplanted kidney, the presence of abnormal signal intensity lesions (ASILs), excluding benign lesions, on SWI was assessed. Renal allograft function was compared between the recipients with and without ASILs. The correlation between ASILs and renal allograft function was tested by Spearman’s rank correlation analysis. Results: Thirty-four recipients were diagnosed with DGF, while 35 recipients showed no DGF. In the DGF group, 16 recipients had low-intensity ASILs, primarily at the corticomedullary junction of transplanted kidneys on SWI, and no ASILs were found in 18 recipients. In the non-DGF group, none of the recipients showed ASILs on SWI. In the DGF group, the renal allograft function among the 16 recipients with low-intensity ASILs was significantly lower than that among the other 18 recipients (8.5 ± 4.2 vs. 19.7 ± 9.7 mL/min, P < 0.001). The presence of low-intensity ASILs on SWI showed a moderate negative correlation with renal allograft function in recipients with DGF (r = − 0.553, P = 0.001). Conclusion: SWI can be used to evaluate DGF in the early post-kidney transplantation period.
KW - Delayed graft function
KW - Diagnostic imaging
KW - Kidney transplantation
KW - Magnetic resonance imaging
KW - Susceptibility-weighted imaging
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U2 - 10.1007/s00261-018-1709-7
DO - 10.1007/s00261-018-1709-7
M3 - Article
C2 - 30054685
AN - SCOPUS:85050801302
SN - 2366-004X
VL - 44
SP - 218
EP - 226
JO - Abdominal Radiology
JF - Abdominal Radiology
IS - 1
ER -