Assessment of delayed graft function using susceptibility-weighted imaging in the early period after kidney transplantation

a feasibility study

Jun Sun, Shengnan Yu, Jie Chen, Zhaoyu Xing, Tingting Zha, Min Fan, Dexing Zeng, Wei Xing

Research output: Contribution to journalArticle

Abstract

Purpose: This study aimed to explore the feasibility of susceptibility-weighted imaging (SWI) for evaluating delayed graft function (DGF) during the early posttransplantation period. Methods: Sixty-nine recipients who accepted allograft renal transplantation underwent SWI during the second posttransplantation week. Renal allograft function was estimated via the glomerular filtration rate. Recipients with and without DGF were identified. For each transplanted kidney, the presence of abnormal signal intensity lesions (ASILs), excluding benign lesions, on SWI was assessed. Renal allograft function was compared between the recipients with and without ASILs. The correlation between ASILs and renal allograft function was tested by Spearman’s rank correlation analysis. Results: Thirty-four recipients were diagnosed with DGF, while 35 recipients showed no DGF. In the DGF group, 16 recipients had low-intensity ASILs, primarily at the corticomedullary junction of transplanted kidneys on SWI, and no ASILs were found in 18 recipients. In the non-DGF group, none of the recipients showed ASILs on SWI. In the DGF group, the renal allograft function among the 16 recipients with low-intensity ASILs was significantly lower than that among the other 18 recipients (8.5 ± 4.2 vs. 19.7 ± 9.7 mL/min, P < 0.001). The presence of low-intensity ASILs on SWI showed a moderate negative correlation with renal allograft function in recipients with DGF (r = − 0.553, P = 0.001). Conclusion: SWI can be used to evaluate DGF in the early post-kidney transplantation period.

Original languageEnglish (US)
Pages (from-to)218-226
Number of pages9
JournalAbdominal Radiology
Volume44
Issue number1
DOIs
StatePublished - Jan 15 2019
Externally publishedYes

Fingerprint

Delayed Graft Function
Feasibility Studies
Kidney Transplantation
Allografts
Kidney
Glomerular Filtration Rate
Transplants

Keywords

  • Delayed graft function
  • Diagnostic imaging
  • Kidney transplantation
  • Magnetic resonance imaging
  • Susceptibility-weighted imaging

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Gastroenterology
  • Urology

Cite this

Assessment of delayed graft function using susceptibility-weighted imaging in the early period after kidney transplantation : a feasibility study. / Sun, Jun; Yu, Shengnan; Chen, Jie; Xing, Zhaoyu; Zha, Tingting; Fan, Min; Zeng, Dexing; Xing, Wei.

In: Abdominal Radiology, Vol. 44, No. 1, 15.01.2019, p. 218-226.

Research output: Contribution to journalArticle

Sun, Jun ; Yu, Shengnan ; Chen, Jie ; Xing, Zhaoyu ; Zha, Tingting ; Fan, Min ; Zeng, Dexing ; Xing, Wei. / Assessment of delayed graft function using susceptibility-weighted imaging in the early period after kidney transplantation : a feasibility study. In: Abdominal Radiology. 2019 ; Vol. 44, No. 1. pp. 218-226.
@article{ef1fa70992f74ecf8429714ab75e2c54,
title = "Assessment of delayed graft function using susceptibility-weighted imaging in the early period after kidney transplantation: a feasibility study",
abstract = "Purpose: This study aimed to explore the feasibility of susceptibility-weighted imaging (SWI) for evaluating delayed graft function (DGF) during the early posttransplantation period. Methods: Sixty-nine recipients who accepted allograft renal transplantation underwent SWI during the second posttransplantation week. Renal allograft function was estimated via the glomerular filtration rate. Recipients with and without DGF were identified. For each transplanted kidney, the presence of abnormal signal intensity lesions (ASILs), excluding benign lesions, on SWI was assessed. Renal allograft function was compared between the recipients with and without ASILs. The correlation between ASILs and renal allograft function was tested by Spearman’s rank correlation analysis. Results: Thirty-four recipients were diagnosed with DGF, while 35 recipients showed no DGF. In the DGF group, 16 recipients had low-intensity ASILs, primarily at the corticomedullary junction of transplanted kidneys on SWI, and no ASILs were found in 18 recipients. In the non-DGF group, none of the recipients showed ASILs on SWI. In the DGF group, the renal allograft function among the 16 recipients with low-intensity ASILs was significantly lower than that among the other 18 recipients (8.5 ± 4.2 vs. 19.7 ± 9.7 mL/min, P < 0.001). The presence of low-intensity ASILs on SWI showed a moderate negative correlation with renal allograft function in recipients with DGF (r = − 0.553, P = 0.001). Conclusion: SWI can be used to evaluate DGF in the early post-kidney transplantation period.",
keywords = "Delayed graft function, Diagnostic imaging, Kidney transplantation, Magnetic resonance imaging, Susceptibility-weighted imaging",
author = "Jun Sun and Shengnan Yu and Jie Chen and Zhaoyu Xing and Tingting Zha and Min Fan and Dexing Zeng and Wei Xing",
year = "2019",
month = "1",
day = "15",
doi = "10.1007/s00261-018-1709-7",
language = "English (US)",
volume = "44",
pages = "218--226",
journal = "Abdominal Radiology",
issn = "2366-004X",
publisher = "Springer New York",
number = "1",

}

TY - JOUR

T1 - Assessment of delayed graft function using susceptibility-weighted imaging in the early period after kidney transplantation

T2 - a feasibility study

AU - Sun, Jun

AU - Yu, Shengnan

AU - Chen, Jie

AU - Xing, Zhaoyu

AU - Zha, Tingting

AU - Fan, Min

AU - Zeng, Dexing

AU - Xing, Wei

PY - 2019/1/15

Y1 - 2019/1/15

N2 - Purpose: This study aimed to explore the feasibility of susceptibility-weighted imaging (SWI) for evaluating delayed graft function (DGF) during the early posttransplantation period. Methods: Sixty-nine recipients who accepted allograft renal transplantation underwent SWI during the second posttransplantation week. Renal allograft function was estimated via the glomerular filtration rate. Recipients with and without DGF were identified. For each transplanted kidney, the presence of abnormal signal intensity lesions (ASILs), excluding benign lesions, on SWI was assessed. Renal allograft function was compared between the recipients with and without ASILs. The correlation between ASILs and renal allograft function was tested by Spearman’s rank correlation analysis. Results: Thirty-four recipients were diagnosed with DGF, while 35 recipients showed no DGF. In the DGF group, 16 recipients had low-intensity ASILs, primarily at the corticomedullary junction of transplanted kidneys on SWI, and no ASILs were found in 18 recipients. In the non-DGF group, none of the recipients showed ASILs on SWI. In the DGF group, the renal allograft function among the 16 recipients with low-intensity ASILs was significantly lower than that among the other 18 recipients (8.5 ± 4.2 vs. 19.7 ± 9.7 mL/min, P < 0.001). The presence of low-intensity ASILs on SWI showed a moderate negative correlation with renal allograft function in recipients with DGF (r = − 0.553, P = 0.001). Conclusion: SWI can be used to evaluate DGF in the early post-kidney transplantation period.

AB - Purpose: This study aimed to explore the feasibility of susceptibility-weighted imaging (SWI) for evaluating delayed graft function (DGF) during the early posttransplantation period. Methods: Sixty-nine recipients who accepted allograft renal transplantation underwent SWI during the second posttransplantation week. Renal allograft function was estimated via the glomerular filtration rate. Recipients with and without DGF were identified. For each transplanted kidney, the presence of abnormal signal intensity lesions (ASILs), excluding benign lesions, on SWI was assessed. Renal allograft function was compared between the recipients with and without ASILs. The correlation between ASILs and renal allograft function was tested by Spearman’s rank correlation analysis. Results: Thirty-four recipients were diagnosed with DGF, while 35 recipients showed no DGF. In the DGF group, 16 recipients had low-intensity ASILs, primarily at the corticomedullary junction of transplanted kidneys on SWI, and no ASILs were found in 18 recipients. In the non-DGF group, none of the recipients showed ASILs on SWI. In the DGF group, the renal allograft function among the 16 recipients with low-intensity ASILs was significantly lower than that among the other 18 recipients (8.5 ± 4.2 vs. 19.7 ± 9.7 mL/min, P < 0.001). The presence of low-intensity ASILs on SWI showed a moderate negative correlation with renal allograft function in recipients with DGF (r = − 0.553, P = 0.001). Conclusion: SWI can be used to evaluate DGF in the early post-kidney transplantation period.

KW - Delayed graft function

KW - Diagnostic imaging

KW - Kidney transplantation

KW - Magnetic resonance imaging

KW - Susceptibility-weighted imaging

UR - http://www.scopus.com/inward/record.url?scp=85050801302&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85050801302&partnerID=8YFLogxK

U2 - 10.1007/s00261-018-1709-7

DO - 10.1007/s00261-018-1709-7

M3 - Article

VL - 44

SP - 218

EP - 226

JO - Abdominal Radiology

JF - Abdominal Radiology

SN - 2366-004X

IS - 1

ER -