Assessing total retinal blood flow in diabetic retinopathy using multiplane en face Doppler optical coherence tomography

Alex D. Pechauer, Thomas S. Hwang, Ahmed M. Hagag, Liang Liu, Ou Tan, Xinbo Zhang, Maria Parker, David Huang, David J. Wilson, Yali Jia

Research output: Research - peer-reviewArticle

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Abstract

Aim To assess total retinal blood flow (TRBF) in diabetic retinopathy (DR) using multiplane en face Doppler optical coherence tomography (OCT). Methods A 70 kHz spectral-domain OCT system scanned a 2×2 mm area centred at the optic disc of the eyes with DR and healthy participants. The multiplane en face Doppler OCT algorithm generated a three-dimensional volumetric data set consisting of 195 en face planes. The TRBF was calculated from the maximum flow values of each branching retinal vein at an optimised en face plane. DR severity was graded according to the international clinical classification system. The generalised linear model method was used to compare flow values between DR groups and the control group. Results A total of 71 eyes from 71 participants were included. Ten eyes were excluded due to poor image quality. The within-visit repeatability of scans was 4.1% (coefficient of variation). There was no significant difference in the TRBF between the healthy (46.7±10.2 μL/min) and mild/moderate non-proliferative DR (44.9±12.6 μL/min) groups. The TRBF in severe nonproliferative DR (39.1±12.6 μL/min) and proliferative DR (28.9±8.85 μL/min) groups were significantly lower (p=0.04 and p<0.0001, respectively) than that of the healthy group. TRBF was correlated with DR disease severity (p<0.0001, linear trend test). Conclusion The novel multiplane en face Doppler OCT method provided reliable measurements of TRBF in DR eyes. This may be a useful tool in understanding the pathophysiology of DR.

LanguageEnglish (US)
JournalBritish Journal of Ophthalmology
DOIs
StateAccepted/In press - May 11 2017

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Optical Coherence Tomography
Diabetic Retinopathy
Retinal Vein
Optic Disk
Linear Models
Healthy Volunteers
Control Groups
Datasets

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

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title = "Assessing total retinal blood flow in diabetic retinopathy using multiplane en face Doppler optical coherence tomography",
abstract = "Aim To assess total retinal blood flow (TRBF) in diabetic retinopathy (DR) using multiplane en face Doppler optical coherence tomography (OCT). Methods A 70 kHz spectral-domain OCT system scanned a 2×2 mm area centred at the optic disc of the eyes with DR and healthy participants. The multiplane en face Doppler OCT algorithm generated a three-dimensional volumetric data set consisting of 195 en face planes. The TRBF was calculated from the maximum flow values of each branching retinal vein at an optimised en face plane. DR severity was graded according to the international clinical classification system. The generalised linear model method was used to compare flow values between DR groups and the control group. Results A total of 71 eyes from 71 participants were included. Ten eyes were excluded due to poor image quality. The within-visit repeatability of scans was 4.1% (coefficient of variation). There was no significant difference in the TRBF between the healthy (46.7±10.2 μL/min) and mild/moderate non-proliferative DR (44.9±12.6 μL/min) groups. The TRBF in severe nonproliferative DR (39.1±12.6 μL/min) and proliferative DR (28.9±8.85 μL/min) groups were significantly lower (p=0.04 and p<0.0001, respectively) than that of the healthy group. TRBF was correlated with DR disease severity (p<0.0001, linear trend test). Conclusion The novel multiplane en face Doppler OCT method provided reliable measurements of TRBF in DR eyes. This may be a useful tool in understanding the pathophysiology of DR.",
author = "Pechauer, {Alex D.} and Hwang, {Thomas S.} and Hagag, {Ahmed M.} and Liang Liu and Ou Tan and Xinbo Zhang and Maria Parker and David Huang and Wilson, {David J.} and Yali Jia",
year = "2017",
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T1 - Assessing total retinal blood flow in diabetic retinopathy using multiplane en face Doppler optical coherence tomography

AU - Pechauer,Alex D.

AU - Hwang,Thomas S.

AU - Hagag,Ahmed M.

AU - Liu,Liang

AU - Tan,Ou

AU - Zhang,Xinbo

AU - Parker,Maria

AU - Huang,David

AU - Wilson,David J.

AU - Jia,Yali

PY - 2017/5/11

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N2 - Aim To assess total retinal blood flow (TRBF) in diabetic retinopathy (DR) using multiplane en face Doppler optical coherence tomography (OCT). Methods A 70 kHz spectral-domain OCT system scanned a 2×2 mm area centred at the optic disc of the eyes with DR and healthy participants. The multiplane en face Doppler OCT algorithm generated a three-dimensional volumetric data set consisting of 195 en face planes. The TRBF was calculated from the maximum flow values of each branching retinal vein at an optimised en face plane. DR severity was graded according to the international clinical classification system. The generalised linear model method was used to compare flow values between DR groups and the control group. Results A total of 71 eyes from 71 participants were included. Ten eyes were excluded due to poor image quality. The within-visit repeatability of scans was 4.1% (coefficient of variation). There was no significant difference in the TRBF between the healthy (46.7±10.2 μL/min) and mild/moderate non-proliferative DR (44.9±12.6 μL/min) groups. The TRBF in severe nonproliferative DR (39.1±12.6 μL/min) and proliferative DR (28.9±8.85 μL/min) groups were significantly lower (p=0.04 and p<0.0001, respectively) than that of the healthy group. TRBF was correlated with DR disease severity (p<0.0001, linear trend test). Conclusion The novel multiplane en face Doppler OCT method provided reliable measurements of TRBF in DR eyes. This may be a useful tool in understanding the pathophysiology of DR.

AB - Aim To assess total retinal blood flow (TRBF) in diabetic retinopathy (DR) using multiplane en face Doppler optical coherence tomography (OCT). Methods A 70 kHz spectral-domain OCT system scanned a 2×2 mm area centred at the optic disc of the eyes with DR and healthy participants. The multiplane en face Doppler OCT algorithm generated a three-dimensional volumetric data set consisting of 195 en face planes. The TRBF was calculated from the maximum flow values of each branching retinal vein at an optimised en face plane. DR severity was graded according to the international clinical classification system. The generalised linear model method was used to compare flow values between DR groups and the control group. Results A total of 71 eyes from 71 participants were included. Ten eyes were excluded due to poor image quality. The within-visit repeatability of scans was 4.1% (coefficient of variation). There was no significant difference in the TRBF between the healthy (46.7±10.2 μL/min) and mild/moderate non-proliferative DR (44.9±12.6 μL/min) groups. The TRBF in severe nonproliferative DR (39.1±12.6 μL/min) and proliferative DR (28.9±8.85 μL/min) groups were significantly lower (p=0.04 and p<0.0001, respectively) than that of the healthy group. TRBF was correlated with DR disease severity (p<0.0001, linear trend test). Conclusion The novel multiplane en face Doppler OCT method provided reliable measurements of TRBF in DR eyes. This may be a useful tool in understanding the pathophysiology of DR.

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